Quoted message said:Subject: Leg cramps
From: Kevin D. Quitt [email hidden]
Date: 11/22/2003 10:56 AM Mountain Standard Time
Message-id: <[email hidden]>
Last night, I started to get leg cramps. Not the who-the-hell-kicked- me-in-my-calf-and-gave-me-a-charlie-
horse, but twitches that would turn into cramps if I don't move or change my position. So I ended
up with virtually no sleep.
What has me really concerned is that I'm still having them. It's almost 10AM, and I'm still having
the them. I don't know what I can do, and I hoping I can buy a clue here.
Quinine ... an iron binder .. first line of defense ..
Since quinine is an iron binder .. and since iron reduction therapy has now been recommended for so
many people with diabetes .. this article which speaks to the use of riboflavin .. ANOTHER iron
binder .. might be of interest.
J Clin Pharmacol 1998 Dec;38(12):1151-4
Randomized, double-blind, placebo-controlled study of the safety and efficacy of vitamin B complex
in the treatment of nocturnal leg cramps in elderly patients with hypertension.
Chan P, Huang TY, Chen YJ, Huang WP, Liu YC Division of Cardiovascular Medicine, Taipei Medical
College, Taipei Wan Fang Hospital, No. 111, Hsin Lung Road, Section 3, Wen Shan, Taipei, Taiwan 117.
Nocturnal leg cramps is a common and troublesome problem in elderly individuals, and their etiology
is unknown. Treatment with quinine is a common practice, but the effectiveness of the drug is
doubtful and adverse drug effects are common. This randomized, double-blind, placebo-controlled
study was conducted to evaluate the safety and efficacy of vitamin B complex capsules
(fursulthiamine 50 mg, hydroxocobalamin 250 micrograms, pyridoxal phosphate 30 mg, and riboflavin 5
mg) in 28 elderly patients with hypertension who had severe nocturnal leg cramps that disturbed
their sleep. Self-reported ratings of leg cramp frequency, duration, and intensity were used to
evaluate severity of nocturnal leg cramps. Both the patients taking vitamin B capsules (n = 14) and
those taking placebo (n = 14) received medications three times daily, and were examined regularly at
2-week intervals for 3 months. After 3 months, 86% of the patients taking vitamin B had prominent
remission of leg cramps, whereas those taking placebo had no significant difference from baseline.
Treatment with vitamin B complex significantly reduced the frequency, intensity, and duration of
nocturnal leg cramps. Because quinine is not without potential for side effects, and vitamin B
complex is a relatively safe and effective alternative, clinicians should reconsider the treatment
of choice for nocturnal leg cramps.
Publication Types:
Clinical trial Randomized controlled trial PMID: 11301568, UI: 21197087
NIGHTTIME LEG CRAMPS A simple stretching exercise has been reported 100% effective in relieving
nocturnal leg cramps. The cramp sufferer is told to stand barefooted, two to three feet from a wall.
Place the hands on the wall, and lean forward, keeping the heels on the floor until a pulling
sensation (but not pain) is felt in the calf. Hold the position for 10 seconds, relax for 5 seconds,
and then repeat. The exercise should be done three times daily until the cramps are gone, and then
repeated as necessary to prevent further cramping. Nearly half of the patients reported total relief
within 24 to 72 hours. All responded within one week. (New England Journal of Medicine
301(4)216, July 26, 1979
Who loves ya. Tom
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