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Re: Fish Oil Processing

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General fitness, health and nutrition
Published
9 June 2006
Last activity
17 June 2006
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Will Brink
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  1. Will Brink said:

    In article <[email hidden]>,

    italiangm said:
    Just Cocky said:

    1) Humans aren't rats;

    True. But rats *are* an excellent model for research that can often be
    extended to humans.

    Depends. They often make a useless model to extend to humans

    If you define "often" as more than 50% "useless", you're dead wrong.

    Quoted message said:

    thus why no researcher worth his salt extrapolates rat studies to humans and
    requires in vivo human data before making any human based conclusions.

    Gee. Ya think? Now look at the context of Just Cocky's pithy argument
    and perhaps you'll discover why the comment you made directly above
    isn't even on the same topic..

  2. In article <[email hidden]>,

    italiangm said:
    Will Brink said:

    In article <[email hidden]>,
    "italiangm" <[email hidden]> wrote:

    Quoted message said:
    Quoted message said:

    Folks that don't get regular exercise, or have an impairment of glucose
    metabolism/insulin resistance should probably cut back on whey/dairy

    Dairy intake is correlated to weight reduction, not weight increases.
    Calcium supps don't appear to have the effect, thus it's not just the
    calcium content of the dairy. Additional mechanisms by which whey may
    improve weight loss:

    Yeah for normoglycemic folks.

    Cite?

    Quoted message said:

    Not true for folks that have metabolic
    impairments related to glucose.

    So you are saying studies find dairy preferentially increase fat mass in
    people with impaired glucose metabolism? Cite?

    --
    Will Brink @ www.BrinkZone.com

  3. In article <[email hidden]>,

    italiangm said:
    Will Brink said:

    In article <[email hidden]>,

    italiangm said:

    Just Cocky wrote:

    > 1) Humans aren't rats;

    True. But rats *are* an excellent model for research that can often be
    extended to humans.

    Depends. They often make a useless model to extend to humans

    If you define "often" as more than 50% "useless", you're dead wrong.

    Cite please.

    --
    Will Brink @ www.BrinkZone.com

  4. italiangm said:
    JMW said:

    Once again: in what products are all these couch potatoes consuming
    pure whey?

    The phrase "pure whey" is meaningless in this discussion. Whey used in
    this example is obtained from separating whey liquid from solid casein
    curd. In cases where whey is a powder, liquid whey is dehydrated.

    OK. Now what are you going to tell me that I didn't know?

    Quoted message said:

    In the study, they mention whey, milk and cheese. They also refer to
    the whey component in milk and cheese as producing an insulin spike,
    just not to the same degree as whey.

    And finally, whey appears in all kinds of products. Cottage cheese ...

    Cottage cheese is casein, Sparky. When the cottage cheese curdles,
    the liquid whey is drained away. That's why it was a somewhat
    worthless by-product of cheese production until its advantage as a
    protein supplement was developed. The residual whey is not
    significant enough to be highly insulinogenic when mixed with the
    casein.

    Quoted message said:

    meal replacement powders and liquids, protein and energy bars,

    .... which are used almost completely by those involved in strength
    training and athletic endeavors. A few moronic couch potatoes may
    consume such items occasionally, rationalizing that those things will
    make them healthy and fit without exercising, but couch potatoes do
    *not* consume those things on a regular basis.

    Quoted message said:

    even
    cold cut meats. The list goes on and on.

    Your list is unconvincing.

    Quoted message said:

    Folks who are normoglycemic,
    glucose intolerant, and diabetic who don't exercise at all consume
    these products containing whey all the time. Diabetics frequently add
    whey to low carb recipes.

    And when you add it to other components, the net effect is to blunt
    the insulinogenic effect. If you didn't know that, you should have.
    In the study you cited, the whey component of milk and cheese elicited
    an insulin response only slightly greater than that of cod and less
    than the white bread control. Only the *pure* whey returned a
    substantial insulin response. (See Figure 4) The real bottom line is
    that relatively *pure* whey, either alone or in conjunction with
    simple sugars, is what is genuinely insulinogenic. The conclusions of
    the study cited acknowledge a probable reason for that response:

    "It cannot be excluded that an elevated plasma amino acid response is
    merely an indicator of the rapid digestion and absorption of whey
    proteins." Nilsson M, Stenberg M, Frid AH, Holst JJ, Bjorck IM.
    Glycemia and insulinemia in healthy subjects after lactose-equivalent
    meals of milk and other food proteins: the role of plasma amino acids
    and incretins. Am J Clin Nutr. 2004 Nov;80(5):1252.

    Fast absorption and the prompt increase in the amino acid pool is why
    those involved in resistance training consume *pure* whey, which is
    usually consumed in conjunction with simple sugars to maximize insulin
    response, thereby creating the ideal milieu for skeletal muscle
    protein synthesis. Couch potatoes do *not* consume such a mixture
    with any regularity, if at all, and you will have a hell of time
    lining up testimonials to establish that they do.

    Quoted message said:

    The point is that these folks who add whey, and don't exercise, check
    their glucose and feel good about what they see. However, the insulin
    spike they get from whey consumption may be the reason why their
    glucose is under control. That insulin spike may also be a key reason
    why risk markers such as Lp(a), homocysteine, and hs-CRP and other
    indicators of inflammation aren't going down as one would expect when
    one maintains good glucose control.

    You're making a mountain out of a molehill by using an scenario that
    does not exist in the real world. Sorry, but I'm just not buying it.

  5. On 12 Jun 2006 13:57:25 -0700, "italiangm" <[email hidden]>

    Quoted message said:


    Just Cocky said:

    Less often than not, I'd say. I don't deny their usefulness but what
    is true for a rat more often than not is not true for a human.

    Not so. In situations where rat model is akin to human model, more
    often than not.

    Well, the problem is that you don't know whether the rat model is akin
    to the human model until after you test the stuff on humans.

    Quoted message said:


    Quoted message said:

    And what is the percentage of successful translations compared to the
    total number of studies?

    At least greater than 50%. And I'm being gratuitously conservative.

    Oh, puleaze!

    --
    "The trouble with the world is that the stupid are
    cocksure and the intelligent are full of doubt"
    -- Bertrand Russell

  6. Just Cocky said:
    Quoted message said:
    Just Cocky said:

    Less often than not, I'd say. I don't deny their usefulness but what
    is true for a rat more often than not is not true for a human.

    Not so. In situations where rat model is akin to human model, more
    often than not.

    Well, the problem is that you don't know whether the rat model is akin
    to the human model until after you test the stuff on humans.

    Quoted message said:


    Quoted message said:

    And what is the percentage of successful translations compared to the
    total number of studies?

    At least greater than 50%. And I'm being gratuitously conservative.


    Oh, puleaze!

    For drugs, the number will depend on which disease is considered.
    There is lots of variation, so the averages are not very meaningful.
    It will also depend on whether we're looking at kinetics parameters,
    toxicity, or efficacy. Predictability for animal models to humans is
    on average about 70% for toxicity and kinetics and about 60% for
    efficacy. Such numbers can be found in the literature on attrition.

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  8. Will Brink <[email hidden]> wrote:

    [...]

    Quoted message said:

    Cite?

    [...]

    Quoted message said:

    Cite?

    Why don't you cite everything you say, [censored]? And offering "Cite?"
    like a parrot is not much of an argument, Brink.

    Cite? Cite? Cite? [censored] want a cracker?

    --
    Curt
    http://curtjames.com/

  9. JMWhat-do-you-buy? said:

    You're making a mountain out of a molehill

    Said the molder of molehills. Some would say that JMW is the Frank
    Lloyd Wright of mountainous molehills, in fact.

    Quoted message said:

    by using an scenario that does not exist in the real world.

    Your frame of reference for "the real world" is, I suspect, lacking.
    Ever actually get out of Ohio?

    Quoted message said:

    Sorry, but I'm just not buying it.

    Of course not. They're disagreeing with you hence your knee jerk
    inflexibility.

    Hth.

    --
    Curt
    http://curtjames.com/

  10. Will Brink <[email hidden]> wrote:

    [...]

    Quoted message said:

    Cite please.

    Is "Will Brink" an autoresponder bot-type thing?

    Cite, cite, cite, cite. Cite, please. Cite? Cite?

    Will, save yourself some time this week. Rather than posting your
    in-depth replies just trust that I'll tack a "Cite please." onto
    everything I read in Usenet until Saturday at midnight, okay?

    --
    Curt
    http://curtjames.com/

  11. DZ said:


    Predictability for animal models to humans is on average about 70%
    for toxicity and kinetics and about 60% for efficacy.

    By animals you are probably including primates as well, no? I'd like
    to see numbers just for rats.

    Quoted message said:


    Such numbers can be found in the literature on attrition.

    Do you have any links? Thanks!

    --
    "The trouble with the world is that the stupid are
    cocksure and the intelligent are full of doubt"
    -- Bertrand Russell

  12. Just Cocky said:
    DZ said:

    Predictability for animal models to humans is on average about 70%
    for toxicity and kinetics and about 60% for efficacy.

    By animals you are probably including primates as well, no? I'd like
    to see numbers just for rats.

    Yes, but these averages are computed in the following manner: given an
    animal model of whatever type, what is the predicted toxicity? Since
    rodent models are a lot more prevalent, the number is not going to
    drop substantially. In other words, these are averages weighted by the
    prevalence of a particular animal type during drug development.

  13. Quoted message said:

    Just Cocky < > By animals you are probably including primates as well,


    no?>>

    I hope that's not true, I surely don't want to be tested.

  14. DZ said:


    Just Cocky said:
    DZ said:

    Predictability for animal models to humans is on average about 70%
    for toxicity and kinetics and about 60% for efficacy.

    By animals you are probably including primates as well, no? I'd like
    to see numbers just for rats.

    Yes, but these averages are computed in the following manner: given an
    animal model of whatever type, what is the predicted toxicity? Since
    rodent models are a lot more prevalent, the number is not going to
    drop substantially. In other words, these are averages weighted by the
    prevalence of a particular animal type during drug development.

    So, at best we have a 60% correlation for eficacy between rats and
    humans. It's not that much better than a flip of a coin, is it?

    --
    "The trouble with the world is that the stupid are
    cocksure and the intelligent are full of doubt"
    -- Bertrand Russell

  15. Just Cocky said:
    DZ said:
    Just Cocky said:

    DZ wrote:
    >Predictability for animal models to humans is on average about 70%
    >for toxicity and kinetics and about 60% for efficacy.

    By animals you are probably including primates as well, no? I'd like
    to see numbers just for rats.

    Yes, but these averages are computed in the following manner: given an
    animal model of whatever type, what is the predicted toxicity? Since
    rodent models are a lot more prevalent, the number is not going to
    drop substantially. In other words, these are averages weighted by the
    prevalence of a particular animal type during drug development.

    So, at best we have a 60% correlation for eficacy between rats and
    humans. It's not that much better than a flip of a coin, is it?

    Depends on what the baseline expectation is. But it is very low, not
    anywhere close to a 50:50 flip coin. If you consider that around 100
    in 100,000 compounds in early screening become viable candidates, 10
    of those become leads, and then most of what remained drop due to
    safety and lack of potency, a flip of a coin is a lot better than pure
    chance.

  16. JMW said:
    italiangm said:

    And finally, whey appears in all kinds of products. Cottage cheese ...

    Cottage cheese is casein, Sparky. When the cottage cheese curdles,
    the liquid whey is drained away. That's why it was a somewhat
    worthless by-product of cheese production until its advantage as a
    protein supplement was developed.

    Right. That's why whey is number 3 in this (and most) product
    ingredient lists:

    http://kraftfoods.com/main.aspx?s=product&m=product/Product_display&Site=1&Product=2100012283

    Quoted message said:

    The residual whey is not significant enough to be highly insulinogenic
    when mixed with the casein.

    "Not significant" is speculative at best and dangerous at worst. Find
    scientific proof that whey contained in diary products and supplements
    in support of your assertion that whey in those products is "not
    significant" and is not "highly insulinogenic". We'll wait.

    Non insulin-dependent diabetics are at risk for escalating effects of
    hyperinsulinemia. It is vital they understand whey's ability to spike
    insulin, especially when they are unable/unwilling to exercise.

    Most of your "information" applies to folks who are bodybuilding. While
    NIDDM folk can be bodybuilders, it's the exception, not the rule.

  17. italiangm said:
    JMW said:
    italiangm said:

    And finally, whey appears in all kinds of products. Cottage cheese ...

    Cottage cheese is casein, Sparky. When the cottage cheese curdles,
    the liquid whey is drained away. That's why it was a somewhat
    worthless by-product of cheese production until its advantage as a
    protein supplement was developed.

    Right. That's why whey is number 3 in this (and most) product
    ingredient lists:

    http://kraftfoods.com/main.aspx?s=product&m=product/Product_display&Site=1&Product=2100012283

    Quoted message said:

    The residual whey is not significant enough to be highly insulinogenic
    when mixed with the casein.

    "Not significant" is speculative at best and dangerous at worst. Find
    scientific proof that whey contained in diary products and supplements
    in support of your assertion that whey in those products is "not
    significant" and is not "highly insulinogenic". We'll wait.

    Jeopardy theme wafts through the newsgroups...

    Quoted message said:

    Non insulin-dependent diabetics are at risk for escalating effects of
    hyperinsulinemia. It is vital they understand whey's ability to spike
    insulin, especially when they are unable/unwilling to exercise.

    Most of your "information" applies to folks who are bodybuilding. While
    NIDDM folk can be bodybuilders, it's the exception, not the rule.

    GET SOME, ITALIA! GET SOME!

    :o)

    --
    Curt
    http://curtjames.com/

  18. italiangm said:


    JMW said:
    italiangm said:

    And finally, whey appears in all kinds of products. Cottage cheese ...

    Cottage cheese is casein, Sparky. When the cottage cheese curdles,
    the liquid whey is drained away. That's why it was a somewhat
    worthless by-product of cheese production until its advantage as a
    protein supplement was developed.

    Right. That's why whey is number 3 in this

    Uh-huh. Right before the "CONTAINS LESS THAN 2% OF" ingredients.
    That proves nothing, and either your know that, or you're a moron.

    Quoted message said:

    http://kraftfoods.com/main.aspx?s=product&m=product/Product_display&Site=1&Product=2100012283

    Quoted message said:

    (and most) product
    ingredient lists:

    Uh-oh! There goes the part where you throw in the gratuitous
    parenthetical "and most" because you know you don't have evidence to
    support that claim.

    Quoted message said:
    Quoted message said:

    The residual whey is not significant enough to be highly insulinogenic
    when mixed with the casein.

    "Not significant" is speculative at best and dangerous at worst. Find
    scientific proof that whey contained in diary products and supplements
    in support of your assertion that whey in those products is "not
    significant" and is not "highly insulinogenic". We'll wait.

    Non insulin-dependent diabetics are at risk for escalating effects of
    hyperinsulinemia. It is vital they understand whey's ability to spike
    insulin, especially when they are unable/unwilling to exercise.

    Most of your "information" applies to folks who are bodybuilding. While
    NIDDM folk can be bodybuilders, it's the exception, not the rule.

    [censored]. Let's consider Type II diabetics. We all know glucose is
    highly insulinogenic. It's been well established that amino acids are
    less insulinogenic, but there's still a significant effect. Most of
    that depends on how fast proteins are broken down into constituent
    amino acids and absorbed through the gut. In one study published
    nearly 15 years ago, glucose had a significant hourly insulinogenic
    response of 732 pmol/L, while cottage cheese had 309 pmol/L, and egg
    whites had 86 pmol/L. Add glucose to either cottage cheese or egg
    whites, and it jumps synergistically: glucose with cottage cheese,
    1,637 pmol/L, and glucose with egg white, 1,213 pmol/L. [1]

    It's about the insulinogenic capacity of amino acids and their
    synergistic combination with simple sugars. There is no evil magic in
    whey; it's simply broken down and absorbed faster, thus leading to a
    faster increase in the amino acid pool. That effect is blunted by
    mixing it with less insulinogenic ingredients, and you have yet to
    establish (even with the link you provided) that foods, other than
    those intended for people involved in substantial exercise, contain a
    significant percentage of whey, anyway.

    [1] Gannon MC, Nuttall FQ, Lane JT, Burmeister LA. Metabolic response
    to cottage cheese or egg white protein, with or without glucose, in
    type II diabetic subjects. Metabolism. 1992 Oct;41(10):1137-45.

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