Diabetes Metab Res Rev. 2006 Feb 28; [Epub ahead of print] Related
Articles, Links
Impact of diabetes mellitus on the relationships between iron-,
inflammatory- and oxidative stress status.
Van Campenhout A, Van Campenhout C, Lagrou AR, Abrams P, Moorkens G,
Van Gaal L, Manuel-Y-Keenoy B.
Laboratory of Endocrinology, University of Antwerp, Belgium.
BACKGROUND: Diabetes is an inflammatory condition associated with iron
abnormalities and increased oxidative damage. We aimed to investigate
how diabetes affects the interrelationships between these pathogenic
mechanisms. METHODS: Glycaemic control, serum iron, proteins involved
in iron homeostasis, global antioxidant capacity and levels of
antioxidants and peroxidation products were measured in 39 type 1 and
67 type 2 diabetic patients and 100 control subjects. RESULTS: Although
serum iron was lower in diabetes, serum ferritin was elevated in type 2
diabetes (p = 0.02). This increase was not related to inflammation
(C-reactive protein) but inversely correlated with soluble transferrin
receptors (r = - 0.38, p = 0.002). Haptoglobin was higher in both type
1 and type 2 diabetes (p < 0.001) and haemopexin was higher in type 2
diabetes (p < 0.001). The relation between C-reactive protein and
haemopexin was lost in type 2 diabetes (r = 0.15, p = 0.27 vs r = 0.63,
p < 0.001 in type 1 diabetes and r = 0.36, p = 0.001 in controls).
Haemopexin levels were independently determined by triacylglycerol
(R(2) = 0.43) and the diabetic state (R(2) = 0.13). Regarding oxidative
stress status, lower antioxidant concentrations were found for retinol
and uric acid in type 1 diabetes, alpha-tocopherol and ascorbate in
type 2 diabetes and protein thiols in both types. These decreases were
partially explained by metabolic-, inflammatory- and iron alterations.
An additional independent effect of the diabetic state on the oxidative
stress status could be identified (R(2) = 0.5-0.14). CONCLUSIONS:
Circulating proteins, body iron stores, inflammation, oxidative stress
and their interrelationships are abnormal in patients with diabetes and
differ between type 1 and type 2 diabetes. Copyright (c) 2006 John
Wiley & Sons, Ltd.
PMID: 16506275 [PubMed - as supplied by publisher]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking