Well...the evidence *supports* causality, but is not conclusive by a long shot. The causality argument is *supported* by the fact that we understand how the vitamins drop homocysteine. So when the vitamins are given to hyperhomocysteinemic individuals and cIMT falls, we know that the associated homocysteine drop wasn't caused by the cIMT drop in some way... But we still don't know that the cIMT drop was due to the homocysteine drop. The study seems to me to rule out causality in the direction of cIMT affects homocysteine, so it strengthens support to causality in the other direction.
But only support or suggestion. No proof. -- Jim Chinnis Warrenton, Virginia, USA
Is it possible then with this interpretation that atherosclerosis itself may cause elevated homocysteine? If so, then the vitamins may be working through a completely different pathway than homocysteine metabolism, correct?
Dr. Blanchard said, in response to Phantom Jim "Is it possible then with this interpretation that atherosclerosis itself may cause elevated homocysteine?"
Well...the evidence *supports* causality, but is not conclusive by a long shot. The causality argument is *supported* by the fact that we understand how the vitamins drop homocysteine. So when the vitamins are given to hyperhomocysteinemic individuals and cIMT falls, we know that the associated homocysteine drop wasn't caused by the cIMT drop in some way... But we still don't know that the cIMT drop was due to the homocysteine drop. The study seems to me to rule out causality in the direction of cIMT affects homocysteine, so it strengthens support to causality in the other direction.
But only support or suggestion. No proof. -- Jim Chinnis Warrenton, Virginia, USA
Is it possible then with this interpretation that atherosclerosis itself may cause elevated homocysteine? If so, then the vitamins may be working through a completely different pathway than homocysteine metabolism, correct?
Dr. Blanchard said, in response to Phantom Jim "Is it possible then with this interpretation that atherosclerosis itself may cause elevated homocysteine?"
Well...the evidence *supports* causality, but is not conclusive by a long shot. The causality argument is *supported* by the fact that we understand how the vitamins drop homocysteine. So when the vitamins are given to hyperhomocysteinemic individuals and cIMT falls, we know that the associated homocysteine drop wasn't caused by the cIMT drop in some way... But we still don't know that the cIMT drop was due to the homocysteine drop. The study seems to me to rule out causality in the direction of cIMT affects homocysteine, so it strengthens support to causality in the other direction.
But only support or suggestion. No proof. -- Jim Chinnis Warrenton, Virginia, USA
Is it possible then with this interpretation that atherosclerosis itself may cause elevated homocysteine? If so, then the vitamins may be working through a completely different pathway than homocysteine metabolism, correct?
Dr. Blanchard said, in response to Phantom Jim "Is it possible then with this interpretation that atherosclerosis itself may cause elevated homocysteine?"
Dr. Blanchard this was my understanding.
B'adant
If I might comment...
It is 'Sonos' who posted the reply.
Are you claiming that 'Sonos' is not Dr. Patrick Blanchard's alias/pseudonym?
