Klin Wochenschr. 1979 Nov 2;57(21):1153-61. Related Articles, Links
Hemodilution (HD) in patients with ischemic skin ulcers.
Rieger H, Kohler M, Schoop W, Schmid-Schonbein H, Roth
FJ, Leyhe A.
In 25 patients with arterial occlusive disease in the
clinical stage IV according to Fontaine a hemodilution down
to an average hematocrit value of .31 +/- 0.02 was
performed. Eighteen patients had peripheral ulcers of the
lower limbs and 3 patients had ulcers of the upper ones.
Four patients had tissular lesions both at the level of the
feet and toes and hand and fingers. The average age of the
patients was 43. Hemodilution was achieved by repeated
withdrawals of approx. 500 ml blood, followed by reinfusion
of the autologous plasma associated with infusion of
substitutive solutions of low-molecular weight dextran to
avoid hypovolemia. In all patients with peripheral ulcers of
the upper limbs, with no exception, a good to a very good
clinical effect was obtained ranging from extended to
complete healing. The healing tendency of lesions in the
feet and toe region was on the whole less marked and
depended basically on the total number of vascular
impediments found in one patient. The rheological and
hemodynamic mechanism of the therapeutic effect of
hemodilution, the preliminary criteria for indicating this
therapy and its observed complications are discussed.
PMID: 513607 [PubMed - indexed for MEDLINE]
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