In article <[email hidden]>,
Anth said:While looking into Kelley/Gonzalez cancer and enzymes I came across the
enzyme absorption dogma.
Here's some links to trash this....
http://news.bbc.co.uk/1/hi/health/1507408.stm
But this doesn't "trash" the observation that, with possibly a couple of
exceptions, unprotected proteins are not absorbed through the GI tract
into the bloodstream in active form in any significant quantity. It
takes some clever and sophisticated chemical and biochemical
manipulations to get proteins to be absorbed in active form through the
digestive tract, as the article whose URL you posted clearly shows.
Quoted message said:It happens in the small intestine - not in the stomach due to the change in
PH.
Here's some other info you might be interested in to support this.
Leipner J, Saller R: Systemic enzyme therapy in oncology: effect and
mode of action. Drugs. 2000;59:769-80.
A review article. From the abstract, it doesn't seem to mention anything
about these enzymes being absorbed systemically, but rather how having a
higher level of enzymes in the small bowel may induce the synthesis of
antiproteases.
Quoted message said:Ambrus JL, et al.: Absorption of exogenous and endogenous proteolytic
enzymes. Clin Pharmacol Therap 1967;8:362-8.
Very old article. I was unable to get the abstract.
Quoted message said:Kleine MW, et al.: The intestinal absorption of orally administered
hydrolytic enzymes and their effects in the treatment of acute herpes
zoster as compared with those of oral acyclovir therapy. Phytomedicine
1995;2:7-15.
Couldn't find this article on Medline.
Quoted message said:Majima Y, et al.: The effect of an orally administered proteolytic
enzyme on the elasticity and viscosity of nasal mucus. Arch
Otorhinolaryngol. 1988;244(6):355-9.
It is not clear from the abstract whether the effect was thought to be
due to systemic effects or local effects on the mucus.
Quoted message said:Castell JV, et al. Intestinal absorption of undegraded proteins in men:
presence of bromelain in plasma after oral intake. Am J Physiol. 1997
Jul;273(1 Pt 1):G139-46.
Interesting article, but the amount absorbed was small and doesn't
demonstrate that the "enzyme therapy" used in some alternative medicine
treatments produces measurable active protein in the blood.
--
Orac |"A statement of fact cannot be insolent."
|
|"If you cannot listen to the answers, why do you
| inconvenience me with questions?"