Wed, 14 Jan 2004 22:05:48 +0200 in article
<[email hidden]> Matti Narkia <[email hidden]>
Quoted message said:There could be some cardioprotective synergism between vitamin E and aspirin (or other COX-2
inhibitors), see
1: Abate A, Yang G, Dennery PA, Oberle S, Schroder H. Synergistic inhibition of cyclooxygenase-2
expression by vitamin E and aspirin. Free Radic Biol Med. 2000 Dec;29(11):1135-42. PMID:
11121721 [PubMed - indexed for MEDLINE] <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd-
=Retrieve&db=PubMed&list_uids=11121721&dopt=Abstract>
2: Polasek J. Acetylsalicylic acid and vitamin E in prevention of arterial thrombosis. Can J
Cardiol. 1997 May;13(5):533-5. PMID: 9179093 [PubMed - indexed for MEDLINE] <URL:http://www.nc-
bi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9179093&dopt=Abstract>
3: Podhaisky HP, Abate A, Polte T, Oberle S, Schroder H. Aspirin protects endothelial cells from
oxidative stress--possible synergism with vitamin E. FEBS Lett. 1997 Nov 17;417(3):349-51.
PMID: 9409749 [PubMed - indexed for MEDLINE] <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcg-
i?cmd=Retrieve&db=PubMed&list_uids=9409749&dopt=Abstract>
4: Cyrus T, Tang LX, Rokach J, FitzGerald GA, Pratico D. Lipid peroxidation and platelet
activation in murine atherosclerosis. Circulation. 2001 Oct 16;104(16):1940-5. PMID: 11602498
[PubMed - indexed for MEDLINE] <URL:http://circ.ahajournals.org/cgi/content/full/104/16/1940>
One more:
Steiner M, Glantz M, Lekos A. Vitamin E plus aspirin compared with aspirin alone in patients with
transient ischemic attacks. Am J Clin Nutr. 1995 Dec;62(6 Suppl):1381S-1384S. PMID: 7495235 [PubMed
- indexed for MEDLINE] <URL:http://www.ajcn.org/cgi/content/abstract/62/6/1381S> <URL:http://www.nc-
bi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=7495235&dopt=Abstract>
Abstract:
"One hundred patients with transient ischemic attacks, minor strokes, or residual ischemic
neurologic deficits were enrolled in a double-blind, randomized study comparing the effects of
aspirin plus vitamin E [0.4 g (400 IU)/d; n = 52] with aspirin alone (325 mg; n = 48). The
patients received study medication for 2 y or until they reached a termination point.
Preliminary results show a significant reduction in the incidence of ischemic events in patients
in the vitamin E plus aspirin group compared with patients taking only aspirin. There was no
significant difference in the incidence of hemorrhagic stroke although both patients who
developed it were taking vitamin E. Platelet adhesion was also measured in a randomized subgroup
of both study populations by using collagen III as the adhesive surface. There was a highly
significant reduction in platelet adhesiveness in patients who were taking vitamin E plus
aspirin compared with those taking aspirin only. Measurement of alpha-tocopherol concentrations
confirmed compliance of the patients with the medication schedule, showing a near doubling of
serum concentrations of alpha-tocopherol. We concluded that the combination of vitamin E and a
platelet antiaggregating agent (eg, aspirin) significantly enhances the efficacy of the
preventive treatment regimen in patients with transient ischemic attacks and other ischemic
cerebrovascular problems."
--
Matti Narkia
