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Vitamin C rather than statin?

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General fitness, health and nutrition
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4 April 2004
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9 April 2004
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Zee
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  1. emediawire.comemw116061.htm

    Canadian Authorities Now Require that Cholesterol-Lowering
    Drug Advertisements Must Carry Warnings about the Dangerous
    Results of Taking these Drugs.

    The popular cholesterol-lowering prescription drugs called
    statins have grown into a huge business; statins are the
    most widely prescribed class of drugs in history. Unlike the
    U.S., Canadian regulatory authorities require several
    additional warnings regarding the statin drugs.

    These hazards are clearly spelled out in the Canadian ads:
    Statins lower coenzyme Q10 (CoQ10) levels and they raise
    Lipoprotein(a)
    [Lp(a)] blood levels. The world needs to know that
    scientists have discovered a perfectly safe and
    natural alternative statin.

    (PRWEB) April 3 2004--Unlike the U.S., Canadian regulatory
    authorities require several warnings regarding statin cholesterol-
    lowering drugs. These popular prescription drugs, including
    Lipitor and Zocor, lower coenzyme Q10 (CoQ10) levels and
    they raise Lipoprotein(a) (Lp(a)) blood levels.

    Low CoQ10 is considered to be a primary cause of congestive
    heart failure, and elevated Lp(a) is a risk factor for
    cardiovascular disease that exceeds the risk of LDL
    cholesterol.

    "Because the U.S. does not require such warnings in drug
    ads, few American doctors are aware of these hazards,"
    writes Owen Fonorow, director of the Houston-based Vitamin C
    Foundation. "Our doctors know that tiny amounts of
    artificial statin drugs can damage the liver, but they are
    not aware that these drugs also increase the risk of heart
    failure and the need for heart transplant."

    In May of 2003, two citizen petitions were filed with the
    Food and Drug Administration (FDA) requesting that the
    agency educate consumers about taking CoQ10 alongside the
    prescription medication. According to Julian Whitaker, M.D.,
    who filed the petitions, statin drugs block the endogenous
    biosynthesis of CoQ10. "A deficiency of CoQ10 is associated
    with impairment of myocardial function, with liver
    dysfunction and with myopathids, including cardiomyopathy
    and congestive heart failure," Whitaker writes.

    All statins – natural or artificial -- lower cholesterol by
    blocking the same essential enzyme HMG-CoA reductase. In
    1985, Harwood, et. al., discovered that ascorbic acid
    (Vitamin C) is the human body's natural HMG-CoA reductase
    inhibitor, without the liver-destroying potential.

    Fonorow writes,"People need to know that there is a
    perfectly safe and natural alternative statin - vitamin C."
    When vitamin C levels are low, the body compensates and
    manufactures more cholesterol. When serum levels are high,
    Vitamin C inhibits HMG-CoA reductase, which predictably
    lowers cholesterol.

    "It appears from the studies and reports we have read that
    the proper dose of vitamin C is between 6000 and 8000 mg
    daily for 3 to 6 months in order to achieve a substantial
    cholesterol-lowering effect in those with high cholesterol,"
    said Fonorow.

    Unlike artificial statins, vitamin C protects the liver,
    increases CoQ10 synthesis and reduces Lp(a) - which hundreds
    of studies have identified as the true culprit in
    cardiovascular disease.

    It is estimated that 15 million Americans take statin drugs.

  2. (Zee) said:

    emediawire.comemw116061.htm

    Canadian Authorities Now Require that Cholesterol-Lowering
    Drug Advertisements Must Carry Warnings about the Dangerous
    Results of Taking these Drugs.

    The popular cholesterol-lowering prescription drugs called
    statins have grown into a huge business; statins are the
    most widely prescribed class of drugs in history. Unlike
    the U.S., Canadian regulatory authorities require several
    additional warnings regarding the statin drugs.

    These hazards are clearly spelled out in the Canadian ads:
    Statins lower coenzyme Q10 (CoQ10) levels and they raise
    Lipoprotein(a)
    [Lp(a)] blood levels. The world needs to know that
    scientists have discovered a perfectly safe and
    natural alternative statin.

    (PRWEB) April 3 2004--Unlike the U.S., Canadian regulatory
    authorities require several warnings regarding statin cholesterol-
    lowering drugs. These popular prescription drugs, including
    Lipitor and Zocor, lower coenzyme Q10 (CoQ10) levels and
    they raise Lipoprotein(a) (Lp(a)) blood levels.

    Low CoQ10 is considered to be a primary cause of congestive
    heart failure, and elevated Lp(a) is a risk factor for
    cardiovascular disease that exceeds the risk of LDL
    cholesterol.

    "Because the U.S. does not require such warnings in drug
    ads, few American doctors are aware of these hazards,"
    writes Owen Fonorow, director of the Houston-based Vitamin
    C Foundation. "Our doctors know that tiny amounts of
    artificial statin drugs can damage the liver, but they are
    not aware that these drugs also increase the risk of heart
    failure and the need for heart transplant."

    In May of 2003, two citizen petitions were filed with
    the Food and Drug Administration (FDA) requesting that
    the agency educate consumers about taking CoQ10
    alongside the prescription medication. According to
    Julian Whitaker, M.D., who filed the petitions, statin
    drugs block the endogenous biosynthesis of CoQ10. "A
    deficiency of CoQ10 is associated with impairment of
    myocardial function, with liver dysfunction and with
    myopathids, including cardiomyopathy and congestive
    heart failure," Whitaker writes.

    All statins – natural or artificial -- lower cholesterol by
    blocking the same essential enzyme HMG-CoA reductase. In
    1985, Harwood, et. al., discovered that ascorbic acid
    (Vitamin C) is the human body's natural HMG-CoA reductase
    inhibitor, without the liver-destroying potential.

    Fonorow writes,"People need to know that there is a
    perfectly safe and natural alternative statin - vitamin C."
    When vitamin C levels are low, the body compensates and
    manufactures more cholesterol. When serum levels are high,
    Vitamin C inhibits HMG-CoA reductase, which predictably
    lowers cholesterol.

    "It appears from the studies and reports we have read that
    the proper dose of vitamin C is between 6000 and 8000 mg
    daily for 3 to 6 months in order to achieve a substantial
    cholesterol-lowering effect in those with high
    cholesterol," said Fonorow.

    Unlike artificial statins, vitamin C protects the liver,
    increases CoQ10 synthesis and reduces Lp(a) - which
    hundreds of studies have identified as the true culprit in
    cardiovascular disease.

    It is estimated that 15 million Americans take statin
    drugs.

    (I gather most of this comes via Linus Pauling)

    Lest anyone decide, from simply reading the above, to start
    ingesting CoQ10 and/or large quantities of vitamin C, please
    be aware that:

    Those on Warfarin (Coumadin) should consult with their
    doctor first.

    Coenzyme Q10 (CoQ10) is structurally similar to vitamin K
    and may affect blood coagulation and case reports have
    suggested that vitamin C might increase the activity of
    anticoagulants in a potentially dangerous way.

    L.

  3. x-no-archive: yes and .... remember NO Grapefruit or
    Grapefruit juice if you're on a statin !

  4. Quoted message said:

    x-no-archive: yes and .... remember NO Grapefruit or
    Grapefruit juice if you're on a statin !

    Why ??? !

  5. liaM said:
    Quoted message said:

    x-no-archive: yes and .... remember NO Grapefruit or
    Grapefruit juice if you're on a statin !

    Why ??? !

    Can increase the statin to toxic levels in the blood stream
    because they contain inhibitors of the metabolic pathways
    (cytochrome P450) that breakdown and inactivate statins.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    heartmdphd.comheartmdphd.com

    **
    Who is the humblest person in the universe?
    makeashorterlink.commakeashorterlink.com

    What is all this about?
    makeashorterlink.commakeashorterlink.com

    Is this spam?
    makeashorterlink.commakeashorterlink.com

  6. MD/PhD said:
    liaM said:
    Quoted message said:

    x-no-archive: yes and .... remember NO Grapefruit or
    Grapefruit juice if you're on a statin !

    Why ??? !

    Can increase the statin to toxic levels in the blood stream
    because they contain inhibitors of the metabolic pathways
    (cytochrome P450) that breakdown and inactivate statins.

    Is there any contraindication for taking Vitamin C with a
    statin? I take 10mg Crestor and 10mg Altace along with a
    multi vitamin, 400IU (natural sources) and 1000mg vitamin C
    and 1g salmon oil capsules.

  7. Sun, 04 Apr 2004 01:00:38 -0500 in article

    Quoted message said:


    Lest anyone decide, from simply reading the above, to start
    ingesting CoQ10 and/or large quantities of vitamin C,
    please be aware that:


    The key word above is _start_ (while on anticoagulants). If
    the diet or supplement program is _changed_ while on
    anticoagulants in such way that it could affect bleeding
    time or other related tests, frequent follow-up is needed to
    _adjust_ the anticoagulant dose to the changed conditions.

    If supplements have been started before anticoagulants,
    the anticoagulant dose will be adjusted to supplements
    from the start.

    --
    Matti Narkia

  8. George said:

    On Sun, 04 Apr 2004 20:07:19 GMT, "Dr. Andrew B. Chung,

    MD/PhD said:
    liaM said:

    [email hidden] wrote:

    > x-no-archive: yes and .... remember NO Grapefruit or
    > Grapefruit juice if you're on a statin !
    >
    >

    Why ??? !

    Can increase the statin to toxic levels in the blood
    stream because they contain inhibitors of the metabolic
    pathways (cytochrome P450) that breakdown and inactivate
    statins.

    Is there any contraindication for taking Vitamin C with
    a statin?

    No.

    Quoted message said:

    I take 10mg Crestor and 10mg Altace along with a multi
    vitamin, 400IU (natural sources) and 1000mg vitamin C and
    1g salmon oil capsules.

    The 400IU of vitamin E may interfere with the effectiveness
    of Crestor.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    heartmdphd.comheartmdphd.com

    **
    Who is the humblest person in the universe?
    makeashorterlink.commakeashorterlink.com

    What is all this about?
    makeashorterlink.commakeashorterlink.com

    Is this spam?
    makeashorterlink.commakeashorterlink.com

  9. Matti Narkia said:

    Sun, 04 Apr 2004 01:00:38 -0500 in article
    <[email hidden]>

    Quoted message said:


    Lest anyone decide, from simply reading the above, to
    start ingesting CoQ10 and/or large quantities of vitamin
    C, please be aware that:


    The key word above is _start_ (while on anticoagulants).
    If the diet or supplement program is _changed_ while on
    anticoagulants in such way that it could affect bleeding
    time or other related tests, frequent follow-up is needed
    to _adjust_ the anticoagulant dose to the changed
    conditions.

    If supplements have been started before anticoagulants,
    the anticoagulant dose will be adjusted to supplements
    from the start.

    --
    Matti Narkia

    I think this perspective is very important. Many people
    take a cautionary view against taking nutritional
    ingredients that augment prescription drugs. The cart is
    before the horse!

    Put the cart where it belongs, behind safer alternatives.

    --
    Winning against heart attack and stroke
    sonoscore.comsonoscore.com

  10. x-no-archive: yes Hi Dr Chung .. my friend Good to see you
    always online : ) I'll never forget the CPK test you
    recommended ! 'houston'

  11. Quoted message said:

    x-no-archive: yes Hi Dr Chung .. my friend Good to see you
    always online : ) I'll never forget the CPK test you
    recommended ! 'houston'

    You're welcome, 'nita :-)

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    heartmdphd.comheartmdphd.com

    **
    Who is the humblest person in the universe?
    makeashorterlink.commakeashorterlink.com

    What is all this about?
    makeashorterlink.commakeashorterlink.com

    Is this spam?
    makeashorterlink.commakeashorterlink.com

  12. (Zee) said:

    Unlike artificial statins, vitamin C protects the liver,
    increases CoQ10 synthesis and reduces Lp(a) - which
    hundreds of studies have identified as the true culprit in
    cardiovascular disease.

    Anyone know about ubiquinone (co-q10) metabolism? Since
    there is a shortage on this compound, how can the body
    reliably make it?

    --
    Winning against heart attack and stroke
    sonoscore.comsonoscore.com

  13. Mon, 5 Apr 2004 22:42:44 GMT in article

    Sonos said:


    (Zee) said:

    Unlike artificial statins, vitamin C protects the liver,
    increases CoQ10 synthesis and reduces Lp(a) - which
    hundreds of studies have identified as the true culprit
    in cardiovascular disease.

    Anyone know about ubiquinone (co-q10) metabolism? Since
    there is a shortage on this compound, how can the body
    reliably make it?

    Here'e a brief summary of biosynthesis of Co Q10,
    copied from

    lpi.oregonstate.educoq10 :

    "Coenzyme Q10 is synthesized in most human tissues. The
    biosynthesis of coenzyme Q10 involves three major steps: 1)
    synthesis of the benzoquinone structure from the amino
    acids, tyrosine or phenylalanine, 2) synthesis of the
    isoprene side chain from acetyl-coenzyme A (CoA) via the
    mevalonate pathway, and 3) the joining or condensation of
    these two structures. The enzyme hydroxymethylglutaryl (HMG)-
    CoA reductase plays a critical role in the regulation of
    coenzyme Q10 synthesis as well as the regulation of
    cholesterol synthesis."

    From the page

    faculty.washington.educoenzq10.html :

    "The relative contribution of CoQ10 biosynthesis versus
    dietary CoQ10 is under investigation. Karl Folkers takes the
    position that the dominant source of CoQ10 in man is
    biosynthesis. This complex, 17 step process, requiring at
    least seven vitamins (vitamin B2 - riboflavin, vitamin B3 -
    niacinamide, vitamin B6, folic acid, vitamin B12, vitamin C,
    and pantothenic acid) and several trace elements, is, by its
    nature, highly vulnerable."

    From the abstract:

    ncbi.nlm.nih.govquery.fcgi
    db=PubMed&list_uids=8702395&dopt=Abstract

    "In the human, coenzyme Q10 (vitamin Q10) is biosynthesized
    from tyrosine through a cascade of eight aromatic
    precursors. These precursors indispensably require eight
    vitamins, which are tetrahydrobiopterin, vitamins B6, C, B2,
    B12, folic acid, niacin, and pantothenic acid as their
    coenzymes. Three of these eight vitamins (the coenzyme B6,
    and the coenzymes niacin and folic acid) are indispensable
    in the biosynthesis of the four bases (thymidine, guanine,
    adenine, and cytosine) of DNA. One or more of the three
    vitamins required for DNA are known to cause abnormal
    pairing of the four bases, which can then result in
    mutations and the diversity of cancer. The coenzyme B6,
    required for the conversion of tyrosine to p-hydroxybenzoic
    acid, is the first coenzyme required in the cascade of
    precursors. A deficiency of the coenzyme B6 can cause
    dysfunctions, prior to the formation of vitamin Q10, to DNA.
    Former data on blood levels of Q10 and new data herein on
    blood levels of B6, measured as EDTA, in cancer patients
    established deficiencies of Q10 and B6 in cancer. This
    complete biochemistry relating to biosyntheses of Q10 and
    the DNA bases is a rationale for the therapy of cancer with
    Q10 and other entities in this biochemistry."

    Other references:

    Crane FL. Biochemical functions of coenzyme Q10. J Am Coll
    Nutr. 2001 Dec;20(6):591-8. Review. PMID: 11771674 [PubMed
    - indexed for MEDLINE] ncbi.nlm.nih.goventrez
    /query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uid-
    s=11771674

    Artuch R, Colome C, Vilaseca MA, Pineda M, Campistol J.
    [Ubiquinone: metabolism and functions. Ubiquinone deficiency
    and its implication in mitochondrial encephalopathies.
    Treatment with ubiquinone] Rev Neurol. 1999 Jul 1-15;29(1):59-
    63. Review. Spanish. PMID: 10528314 [PubMed - indexed for
    MEDLINE] ncbi.nlm.nih.govquery.fcgi
    Retrieve&db=pubmed&dopt=Abstract&list_uids=10528314

    --
    Matti Narkia

  14. Matti Narkia said:

    Artuch R, Colome C, Vilaseca MA, Pineda M, Campistol J.
    [Ubiquinone: metabolism and functions. Ubiquinone
    deficiency and its implication in mitochondrial
    encephalopathies. Treatment with ubiquinone] Rev Neurol.
    1999 Jul 1-15;29(1):59-63. Review. Spanish. PMID: 10528314
    [PubMed - indexed for MEDLINE] ncbi.nlm.nih.go-ncbi.nlm.nih.go-
    v/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&-
    list_uids=10528314

    excerpt: Mitochondrial encephalomyopathies may be related to
    a primary or secondary ubiquinone deficient status

    .. interesting. perhaps this is where all the confusion
    about statins originates 🙂

    --
    Winning against heart attack and stroke
    sonoscore.comsonoscore.com

  15. "Sonos" <[email hidden]> wrote in message news:<[email hidden]>...

    Quoted message said:
    Matti Narkia said:

    Sun, 04 Apr 2004 01:00:38 -0500 in article
    <[email hidden]>

    Quoted message said:


    Lest anyone decide, from simply reading the above, to
    start ingesting CoQ10 and/or large quantities of
    vitamin C, please be aware that:


    The key word above is _start_ (while on anticoagulants).
    If the diet or supplement program is _changed_ while on
    anticoagulants in such way that it could affect bleeding
    time or other related tests, frequent follow-up is
    needed to _adjust_ the anticoagulant dose to the changed
    conditions.

    If supplements have been started before anticoagulants,
    the anticoagulant dose will be adjusted to supplements
    from the start.

    --
    Matti Narkia

    I think this perspective is very important. Many people
    take a cautionary view against taking nutritional
    ingredients that augment prescription drugs. The cart is
    before the horse!

    Put the cart where it belongs, behind safer alternatives.

    Are there any dangers (side effects) to taking such a high
    amount of Vitamin C as, for example, George uses, or as is
    recommended in the article?

    Dr. Chung do you have a comment? I would like to hear from
    both of you. I respect your point of view, with
    regards to me.

    B'adant

  16. MD/PhD said:
    George said:

    On Sun, 04 Apr 2004 20:07:19 GMT, "Dr. Andrew B. Chung,

    MD/PhD said:

    liaM wrote:

    > [email hidden] wrote:
    >
    > > x-no-archive: yes and .... remember NO Grapefruit or
    > > Grapefruit juice if you're on a statin !
    > >
    > >
    >
    > Why ??? !

    Can increase the statin to toxic levels in the blood
    stream because they contain inhibitors of the metabolic
    pathways (cytochrome P450) that breakdown and inactivate
    statins.

    Is there any contraindication for taking Vitamin C with a
    statin?

    No.

    Quoted message said:

    I take 10mg Crestor and 10mg Altace along with a multi
    vitamin, 400IU (natural sources) and 1000mg vitamin C
    and 1g salmon oil capsules.

    The 400IU of vitamin E may interfere with the effectiveness
    of Crestor.

    Maybe you could give us a brief rundown on the common
    statins and what to avoid while on them. I see
    grapefruit universally for all statins. Is this true fro
    Vitamin E as well?

    Quoted message said:

    Servant to the humblest person in the universe,

    Andrew

  17. On Tue, 06 Apr 2004 02:52:22 +0300, Matti Narkia <[email hidden]>

    Quoted message said:

    Mon, 5 Apr 2004 22:42:44 GMT in article
    <[email hidden]> "Sonos"

    Quoted message said:


    (Zee) said:

    Unlike artificial statins, vitamin C protects the liver,
    increases CoQ10 synthesis and reduces Lp(a) - which
    hundreds of studies have identified as the true culprit
    in cardiovascular disease.

    Anyone know about ubiquinone (co-q10) metabolism? Since
    there is a shortage on this compound, how can the body
    reliably make it?

    Here'e a brief summary of biosynthesis of Co Q10,
    copied from

    lpi.oregonstate.educoq10 :

    "Coenzyme Q10 is synthesized in most human tissues. The
    biosynthesis of coenzyme Q10 involves three major steps: 1)
    synthesis of the benzoquinone structure from the amino
    acids, tyrosine or phenylalanine, 2) synthesis of the
    isoprene side chain from acetyl-coenzyme A (CoA) via the
    mevalonate pathway, and 3) the joining or condensation of
    these two structures. The enzyme hydroxymethylglutaryl (HMG)-
    CoA reductase plays a critical role in the regulation of
    coenzyme Q10 synthesis as well as the regulation of
    cholesterol synthesis."

    From the page

    faculty.washington.educoenzq10.html :

    "The relative contribution of CoQ10 biosynthesis versus
    dietary CoQ10 is under investigation. Karl Folkers takes
    the position that the dominant source of CoQ10 in man is
    biosynthesis. This complex, 17 step process, requiring at
    least seven vitamins (vitamin B2 - riboflavin, vitamin B3 -
    niacinamide, vitamin B6, folic acid, vitamin B12, vitamin
    C, and pantothenic acid) and several trace elements, is, by
    its nature, highly vulnerable."

    From the abstract:

    ncbi.nlm.nih.govquery.fcgi
    &db=PubMed&list_uids=8702395&dopt=Abstract

    "In the human, coenzyme Q10 (vitamin Q10) is biosynthesized
    from tyrosine through a cascade of eight aromatic
    precursors. These precursors indispensably require eight
    vitamins, which are tetrahydrobiopterin, vitamins B6, C,
    B2, B12, folic acid, niacin, and pantothenic acid as their
    coenzymes. Three of these eight vitamins (the coenzyme B6,
    and the coenzymes niacin and folic acid) are indispensable
    in the biosynthesis of the four bases (thymidine, guanine,
    adenine, and cytosine) of DNA. One or more of the three
    vitamins required for DNA are known to cause abnormal
    pairing of the four bases, which can then result in
    mutations and the diversity of cancer. The coenzyme B6,
    required for the conversion of tyrosine to p-hydroxybenzoic
    acid, is the first coenzyme required in the cascade of
    precursors. A deficiency of the coenzyme B6 can cause
    dysfunctions, prior to the formation of vitamin Q10, to
    DNA. Former data on blood levels of Q10 and new data herein
    on blood levels of B6, measured as EDTA, in cancer patients
    established deficiencies of Q10 and B6 in cancer. This
    complete biochemistry relating to biosyntheses of Q10 and
    the DNA bases is a rationale for the therapy of cancer with
    Q10 and other entities in this biochemistry."

    Other references:

    Crane FL. Biochemical functions of coenzyme Q10. J Am Coll
    Nutr. 2001 Dec;20(6):591-8. Review. PMID: 11771674 [PubMed
    - indexed for MEDLINE] ncbi.nlm.nih.goventrez
    /query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uid-
    s=11771674

    Artuch R, Colome C, Vilaseca MA, Pineda M, Campistol J.
    [Ubiquinone: metabolism and functions. Ubiquinone
    deficiency and its implication in mitochondrial
    encephalopathies. Treatment with ubiquinone] Rev Neurol.
    1999 Jul 1-15;29(1):59-63. Review. Spanish. PMID: 10528314
    [PubMed - indexed for MEDLINE] ncbi.nlm.nih.gov-ncbi.nlm.nih.gov-
    /entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li-
    st_uids=10528314

    How much CoQ10 should one supplement when using statins?
    What's your take on the Vitamin C claim?

  18. "Dr. Andrew B. Chung, MD/PhD" <[email hidden]> wrote in message news:<[email hidden]>...

    Quoted message said:
    George said:

    On Sun, 04 Apr 2004 20:07:19 GMT, "Dr. Andrew B. Chung,

    MD/PhD said:

    liaM wrote:

    > [email hidden] wrote:
    >
    > > x-no-archive: yes and .... remember NO Grapefruit
    > > or Grapefruit juice if you're on a statin !
    > >
    > >
    >
    > Why ??? !

    Can increase the statin to toxic levels in the blood
    stream because they contain inhibitors of the metabolic
    pathways (cytochrome P450) that breakdown and
    inactivate statins.

    Is there any contraindication for taking Vitamin C with
    a statin?

    No.

    Quoted message said:

    I take 10mg Crestor and 10mg Altace along with a multi
    vitamin, 400IU (natural sources) and 1000mg vitamin C
    and 1g salmon oil capsules.

    The 400IU of vitamin E may interfere with the
    effectiveness of Crestor.

    Servant to the humblest person in the universe,

    Andrew

    Also, Drs. Chung and Dr. Blanchard, what is the point of
    taking folate to lower homocysteine? Isn't an elevated
    homocysteine just a marker of something? If I lower the
    homocysteine, does whatever caused it to elevate go away?
    Seriously. Isn't it just a marker? Help me out here. B'adant

  19. Zee said:

    "Sonos" <[email hidden]> wrote in message
    news:<[email hidden]>...

    Quoted message said:
    Matti Narkia said:

    Sun, 04 Apr 2004 01:00:38 -0500 in article
    <[email hidden]>
    [email hidden] wrote:
    >
    >Lest anyone decide, from simply reading the above, to
    >start ingesting CoQ10 and/or large quantities of
    >vitamin C, please be aware that:
    >
    The key word above is _start_ (while on
    anticoagulants). If the diet or supplement program is
    _changed_ while on anticoagulants in such way that it
    could affect bleeding time or other related tests,
    frequent follow-up is needed to _adjust_ the
    anticoagulant dose to the changed conditions.

    If supplements have been started before
    anticoagulants, the anticoagulant dose will be
    adjusted to supplements from the start.

    --
    Matti Narkia

    I think this perspective is very important. Many people
    take a cautionary view against taking nutritional
    ingredients that augment prescription drugs. The cart is
    before the horse!

    Put the cart where it belongs, behind safer
    alternatives.

    Are there any dangers (side effects) to taking such a high
    amount of Vitamin C as, for example, George uses, or as is
    recommended in the article?

    Dr. Chung do you have a comment?

    I would wonder about efficacy:

    makeashorterlink.commakeashorterlink.com

    I would also wonder about potential harm:

    makeashorterlink.commakeashorterlink.com

    So I would wait for good trials to show benefit of high dose
    Vitamin C.

    Quoted message said:

    I would like to hear from both of you. I respect your
    point of view, with regards to me.

    B'adant

    You got it :-)

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    heartmdphd.comheartmdphd.com

    **
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    makeashorterlink.commakeashorterlink.com

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  20. Zee said:

    "Dr. Andrew B. Chung, MD/PhD" <[email hidden]>
    wrote in message news:<60da91fc23604d9710085763cccc1448@n-
    ews.teranews.com>...

    Quoted message said:
    George said:

    On Sun, 04 Apr 2004 20:07:19 GMT, "Dr. Andrew B.
    Chung, MD/PhD" <[email hidden]> wrote:

    >liaM wrote:
    >
    >> [email hidden] wrote:
    >>
    >> > x-no-archive: yes and .... remember NO Grapefruit
    >> > or Grapefruit juice if you're on a statin !
    >> >
    >> >
    >>
    >> Why ??? !
    >
    >Can increase the statin to toxic levels in the blood
    >stream because they contain inhibitors of the
    >metabolic pathways (cytochrome P450) that breakdown
    >and inactivate statins.

    Is there any contraindication for taking Vitamin C
    with a statin?

    No.

    Quoted message said:

    I take 10mg Crestor and 10mg Altace along with a
    multi vitamin, 400IU (natural sources) and 1000mg
    vitamin C and 1g salmon oil capsules.

    The 400IU of vitamin E may interfere with the
    effectiveness of Crestor.

    Servant to the humblest person in the universe,

    Andrew

    Also, Drs. Chung and Dr. Blanchard, what is the point of
    taking folate to lower homocysteine?

    Folate should be taken with B12 and B6 to lower
    homocysteine.

    Quoted message said:

    Isn't an elevated homocysteine just a marker of something?

    No.

    Quoted message said:

    If I lower the homocysteine, does whatever caused it to
    elevate go away?

    No.

    Quoted message said:

    Seriously. Isn't it just a marker?

    No. It is a metabolite that is directly toxic to the
    endothelium.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    heartmdphd.comheartmdphd.com

    **
    Who is the humblest person in the universe?
    makeashorterlink.commakeashorterlink.com

    What is all this about?
    makeashorterlink.commakeashorterlink.com

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