General fitness, health and nutrition · Public discussion

Vitamin C plasma concentration / oxidative stress

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12 June 2005
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  1. Physiol Res. 2005 May 24; [Epub ahead of print] Related Articles, Links

    Products of DNA, protein and lipid oxidative damage in relation to
    vitamin C plasma concentration.

    Krajcovicova-Kudlackova M, Dusinska M, Valachovicova M, Blazicek P,
    Paukova V.

    Slovak Medical University, Limbova 12, 833 03 Bratislava 37, Slovak
    Republic. [email hidden].

    Oxidative stress plays an important role in pathogenesis of numerous
    chronic age-related free radical-induced diseases. Improved antioxidant
    status minimizes oxidative damage to DNA, proteins, lipids and other
    biomolecules. Diet-derived antioxidants such as vitamin C, vitamin E,
    carotenoids and related plant pigments are important in antioxidative
    defense and maintaining health. The results of long-term
    epidemiological and clinical studies suggest that protective vitamin C
    plasma concentration for minimum risk of free radical disease is higher
    than 50 micromol/l. Products of oxidative damage to DNA (DNA strand
    breaks with oxidized purines and pyrimidines), proteins (carbonyls) and
    lipids (conjugated dienes of fatty acids, malondialdehyde) were
    estimated in group of apparently healthy adult non-smoking population
    in dependence to different vitamin C plasma concentrations. At
    conditions of protective plasma vitamin C concentration (>50
    micromol/l) were recorded significantly lower values of DNA, protein
    and lipid oxidative damage in comparison with vitamin C deficient group
    (<50 micromol/l). The inhibition effect of higher fruit and vegetable
    consumption higher vitamin C intake higher vitamin C plasma
    concentration on oxidation of DNA, proteins and lipids is expressed
    also by inverse significant correlation between plasma vitamin C and
    products of oxidative damage. The results suggest an important role of
    higher and frequent consumption of protective food (fruit, vegetables,
    vegetable oils, nuts, seeds and cereal grains) in prevention of free
    radical disease.

    PMID: 15910173 [PubMed - as supplied by publisher]

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  2. [email hidden]:

    Quoted message said:

    Oxidative stress plays an important role in pathogenesis of
    numerous chronic age-related free radical-induced diseases.
    Improved antioxidant status minimizes oxidative damage to DNA,
    proteins, lipids and other biomolecules. The results of long-term
    epidemiological and clinical studies suggest that protective vitamin C
    plasma concentration for minimum risk of free radical disease is higher
    than 50 micromol/l. Products of oxidative damage to DNA (DNA strand
    breaks with oxidized purines and pyrimidines), proteins (carbonyls) and
    lipids (conjugated dienes of fatty acids, malondialdehyde) were
    estimated in group of apparently healthy adult non-smoking population
    in dependence to different vitamin C plasma concentrations. At
    conditions of protective plasma vitamin C concentration (>50
    micromol/l) were recorded significantly lower values of DNA, protein
    and lipid oxidative damage in comparison with vitamin C deficient group
    (<50 micromol/l). The inhibition effect of higher fruit and vegetable
    consumption higher vitamin C intake higher vitamin C plasma
    concentration on oxidation of DNA, proteins and lipids is expressed
    also by inverse significant correlation between plasma vitamin C and
    products of oxidative damage. The results suggest an important role of
    higher and frequent consumption of protective food (fruit, vegetables,
    vegetable oils, nuts, seeds and cereal grains) in prevention of free
    radical disease.

    In context those protective food like vegetables which are rich of
    neutralizing antioxidans (vit C, E, carotinoids...) help to support
    the acid cousin equilibrium of the body. Overacidification of body
    (cause of many illnesses caused by civilization) stands in close
    connection to oxidative stress. The defense of harmful affluence of
    Free Radicals (which already develop with the usual energy burn process
    and 'll attack the organism by accumulated external factors which are
    considered as primary FR-sources) is needed to guard against oxidative
    DNA damage and - by neutralizing the acided body - helps to guard
    against the growth of cancer cells. Nice origination u performed, but
    with your mentioned above quantity specifications I can't agree however.

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