Physiol Res. 2005 May 24; [Epub ahead of print] Related Articles, Links
Products of DNA, protein and lipid oxidative damage in relation to
vitamin C plasma concentration.
Krajcovicova-Kudlackova M, Dusinska M, Valachovicova M, Blazicek P,
Paukova V.
Slovak Medical University, Limbova 12, 833 03 Bratislava 37, Slovak
Republic. [email hidden].
Oxidative stress plays an important role in pathogenesis of numerous
chronic age-related free radical-induced diseases. Improved antioxidant
status minimizes oxidative damage to DNA, proteins, lipids and other
biomolecules. Diet-derived antioxidants such as vitamin C, vitamin E,
carotenoids and related plant pigments are important in antioxidative
defense and maintaining health. The results of long-term
epidemiological and clinical studies suggest that protective vitamin C
plasma concentration for minimum risk of free radical disease is higher
than 50 micromol/l. Products of oxidative damage to DNA (DNA strand
breaks with oxidized purines and pyrimidines), proteins (carbonyls) and
lipids (conjugated dienes of fatty acids, malondialdehyde) were
estimated in group of apparently healthy adult non-smoking population
in dependence to different vitamin C plasma concentrations. At
conditions of protective plasma vitamin C concentration (>50
micromol/l) were recorded significantly lower values of DNA, protein
and lipid oxidative damage in comparison with vitamin C deficient group
(<50 micromol/l). The inhibition effect of higher fruit and vegetable
consumption higher vitamin C intake higher vitamin C plasma
concentration on oxidation of DNA, proteins and lipids is expressed
also by inverse significant correlation between plasma vitamin C and
products of oxidative damage. The results suggest an important role of
higher and frequent consumption of protective food (fruit, vegetables,
vegetable oils, nuts, seeds and cereal grains) in prevention of free
radical disease.
PMID: 15910173 [PubMed - as supplied by publisher]
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