1: Nutrition. 2004 Oct;20(10):863-6. Related Articles, Links
Effects of a long-term vegetarian diet on biomarkers of antioxidant status
and cardiovascular disease risk.
Szeto YT, Kwok TC, Benzie IF.
Antioxidant Research Team, School of Nursing, The Hong Kong Polytechnic
University, Kowloon, Hong Kong SAR, China.
OBJECTIVE: We compared plasma biomarkers of antioxidant status, oxidative
stress, inflammation, and risk for coronary heart disease in long-term
vegetarians and age- and sex-matched omnivores. METHODS: Thirty vegetarians
(mean age +/- standard deviation: 44.2 +/- 9.0 y) were recruited. The
subjects had been vegetarian for 5 to 55 y (21.8 +/- 12.2 y). The control
group comprised 30 adults selected by age-stratified sampling from a
community health project (mean age: 44.0 +/- 9.2 y). Fasting plasma total
antioxidant status (ferric-reducing antioxidant power), ascorbic acid (AA),
alpha-tocopherol (total and lipid standardized), malondialdehyde, total
cholesterol, triacylglycerol, uric acid (UA), and high-sensitivity
C-reactive protein (hsCRP) were measured. RESULTS: Plasma AA was
significantly higher in the vegetarians than in the omnivores (90.5 +/- 21.0
and 61.8 +/- 17.0 microM; P < 0.001). The vegetarians had lower
concentrations of triacylglycerol, UA, and hsCRP. Plasma total and
lipid-standardized alpha-tocopherol concentrations were also lower in the
vegetarians: 22.0 +/- 5.9 and 27.0 +/- 7.9 microM versus 3.76 +/- 0.57 and
4.23 +/- 0.58 microM per millimoles per liter of total cholesterol plus
triacylglycerol, respectively. There was a significant inverse correlation
between AA and UA (r = -0.343, P < 0.01; n = 60) and between AA and hsCRP (r
= -0.306, P < 0.05; n = 55). Plasma ferric-reducing antioxidant power and
malondialdehyde did not differ significantly between groups; however, the
contribution of AA to the total antioxidant capacity of plasma was
approximately 50% greater in the vegetarians. CONCLUSIONS: A long-term
vegetarian diet is associated with markedly higher fasting plasma AA
concentrations and lower concentrations of TAG, UA, and hsCRP. Long-term
vegetarians have a better antioxidant status and coronary heart disease risk
profile than do apparently healthy omnivores. Plasma AA may act a useful
marker of overall health status.
PMID: 15474873 [PubMed - indexed for MEDLINE]