Topically applied lipids / alternative to 'ORTHODOX' application?

I have read that topically applied lipids can be used in patients on long
term parenteral nutrition who cannot take intravenous lipids to prevent
essential fatty acid deficiency. I do not know how much would cross the
skin, but as lipids are obviously lipid soluble, some absorption would be
expected.

<[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

These two studies imply linoleic acid is an iron chelator / binder and
effectively removes iron / hemosiderin from the skin .. ?

This would mean topically applied lipids DO cross the skin .. ?

Would anyone have any idea as to WHERE to find the AMOUNT of the lipids
applied to the skin .. which .. would ENTER INTACT .. fully .. into the
body .. ?

If it has EVER been .. actually .. tested .. ?

-----------------------------------------------------------------
Biol Pharm Bull. 2004 Apr;27(4):591-4. Related Articles, Links

Skin whitening effect of linoleic acid is enhanced by liposomal
formulations.

Shigeta Y, Imanaka H, Ando H, Ryu A, Oku N, Baba N, Makino T.

Department of Bioresources Chemistry, Faculty of Agriculture, Okayama
University, 1-1-1 Tsushimanaka, Okayama 700-8530, Japan.
[email hidden]

Linoleic acid (LA) is known to have a whitening effect on
hyperpigmented skin, and is encapsulated in liposomes for topical
application because of its low solubility in aqueous solution, although
the effect of liposomalization of LA on the whitening activity has not
been evaluated. In the present study, we evaluated the effect of
liposomalization on the whitening activity of LA by using LA in
ethanol, hydrogel containing LA, and hydrogel containing liposomal LA
towards the UV-stimulated hyperpigmented dorsal skin of brownish guinea
pigs. The whitening effect was far greater for hydrogel containing
liposomal LA (0.1% w/w as a final concentration of LA) than for free LA
in ethanol or hydrogel containing LA. Next, the whitening effect of LA
was examined with UV-stimulated hyperpigmented human upper arm skin by
using a hydrogel containing liposomal LA (0.1% LA) and non-liposomal LA
(3.0, 10.0% LA). Liposomal LA (0.1%) showed a whitening effect
comparable to 10.0% non-liposomal LA and was far more effective than
3.0% non-liposomal LA. These results indicate that liposomal
formulations are favorable for the transdermal application of LA.

Publication Types:
Clinical Trial

PMID: 15056874 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

Acta Derm Venereol. 1980;60(2):109-14. Related Articles, Links

Experimental hemosiderosis: relationship between skin pigmentation and
hemosiderin.

Tsuji T.

Iron (totalling 7.5 mg per mouse in three doses) was injected into
hairless mice to determine the relationship between skin pigmentation
and hemosiderin deposition. The skin color reached its maximum 24 to 48
hours after the last injection and then gradually faded over the
subsequent 8 months. In the skin, hemosiderin granules were present
extracellularly between collagen bundles as well as within dermal
macrophages, Langerhans cells and indeterminate dendritic cells of the
epidermis. A larger amount of iron was deposited in the facial than in
the dorsal skin, resulting in darker pigmentation of the former. This
study suggests that brownish discoloration of skin in hemochromatosis
might be attributable in some degree to accumulation of hemosiderin and
that pronounced hyperpigmentation of the face in hemochromatosis might
be due to increased activation of melanocytes by a high content of
hemosiderin.

PMID: 6155014 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

Who loves ya.
Tom

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http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
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I previously said transdermal oils will penetrate the skin, but most
references I have looked up on Pubmed suggest that the amount that reaches
the body is limited, not enough to prevent essential fatty deficiency at
least in patients on fat free parenteral nutrition
<[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

These two studies imply linoleic acid is an iron chelator / binder and
effectively removes iron / hemosiderin from the skin .. ?

This would mean topically applied lipids DO cross the skin .. ?

Would anyone have any idea as to WHERE to find the AMOUNT of the lipids
applied to the skin .. which .. would ENTER INTACT .. fully .. into the
body .. ?

If it has EVER been .. actually .. tested .. ?

-----------------------------------------------------------------
Biol Pharm Bull. 2004 Apr;27(4):591-4. Related Articles, Links

Skin whitening effect of linoleic acid is enhanced by liposomal
formulations.

Shigeta Y, Imanaka H, Ando H, Ryu A, Oku N, Baba N, Makino T.

Department of Bioresources Chemistry, Faculty of Agriculture, Okayama
University, 1-1-1 Tsushimanaka, Okayama 700-8530, Japan.
[email hidden]

Linoleic acid (LA) is known to have a whitening effect on
hyperpigmented skin, and is encapsulated in liposomes for topical
application because of its low solubility in aqueous solution, although
the effect of liposomalization of LA on the whitening activity has not
been evaluated. In the present study, we evaluated the effect of
liposomalization on the whitening activity of LA by using LA in
ethanol, hydrogel containing LA, and hydrogel containing liposomal LA
towards the UV-stimulated hyperpigmented dorsal skin of brownish guinea
pigs. The whitening effect was far greater for hydrogel containing
liposomal LA (0.1% w/w as a final concentration of LA) than for free LA
in ethanol or hydrogel containing LA. Next, the whitening effect of LA
was examined with UV-stimulated hyperpigmented human upper arm skin by
using a hydrogel containing liposomal LA (0.1% LA) and non-liposomal LA
(3.0, 10.0% LA). Liposomal LA (0.1%) showed a whitening effect
comparable to 10.0% non-liposomal LA and was far more effective than
3.0% non-liposomal LA. These results indicate that liposomal
formulations are favorable for the transdermal application of LA.

Publication Types:
Clinical Trial

PMID: 15056874 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

Acta Derm Venereol. 1980;60(2):109-14. Related Articles, Links

Experimental hemosiderosis: relationship between skin pigmentation and
hemosiderin.

Tsuji T.

Iron (totalling 7.5 mg per mouse in three doses) was injected into
hairless mice to determine the relationship between skin pigmentation
and hemosiderin deposition. The skin color reached its maximum 24 to 48
hours after the last injection and then gradually faded over the
subsequent 8 months. In the skin, hemosiderin granules were present
extracellularly between collagen bundles as well as within dermal
macrophages, Langerhans cells and indeterminate dendritic cells of the
epidermis. A larger amount of iron was deposited in the facial than in
the dorsal skin, resulting in darker pigmentation of the former. This
study suggests that brownish discoloration of skin in hemochromatosis
might be attributable in some degree to accumulation of hemosiderin and
that pronounced hyperpigmentation of the face in hemochromatosis might
be due to increased activation of melanocytes by a high content of
hemosiderin.

PMID: 6155014 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

THAT is EXACTLY what I am looking for .. annointing .. of .. oil ..

Maybe I'll have to pull out some of the .. older .. texts .. 😉

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

Acta Paediatr. 2002;91(5):546-54. Related Articles, Links

Impact of topical oils on the skin barrier: possible implications for
neonatal health in developing countries.

Darmstadt GL, Mao-Qiang M, Chi E, Saha SK, Ziboh VA, Black RE,
Santosham M, Elias PM.

Department of International Health, Bloomberg School of Public Health,
The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
[email hidden]

Topical therapy to enhance skin barrier function may be a simple,
low-cost, effective strategy to improve outcome of preterm infants with
a developmentally compromised epidermal barrier, as lipid constituents
of topical products may act as a mechanical barrier and augment
synthesis of barrier lipids. Natural oils are applied topically as part
of a traditional oil massage to neonates in many developing countries.
We sought to identify inexpensive, safe, vegetable oils available in
developing countries that improved epidermal barrier function. The
impact of oils on mouse epidermal barrier function (rate of
transepidermal water loss over time following acute barrier disruption
by tape-stripping) and ultrastructure was determined. A single
application of sunflower seed oil significantly accelerated skin
barrier recovery within 1 h; the effect was sustained 5 h after
application. In contrast, the other vegetable oils tested (mustard,
olive and soybean oils) all significantly delayed recovery of barrier
function compared with control- or Aquaphor-treated skin. Twice-daily
applications of mustard oil for 7 d resulted in sustained delay of
barrier recovery. Moreover, adverse ultrastructural changes were seen
under transmission electron microscopy in keratin intermediate
filament, mitochondrial, nuclear, and nuclear envelope structure
following a single application of mustard oil. Conclusion: Our data
suggest that topical application of linoleate-enriched oil such as
sunflower seed oil might enhance skin barrier function and improve
outcome in neonates with compromised barrier function. Mustard oil,
used routinely in newborn care throughout South Asia, has toxic effects
on the epidermal barrier that warrant further investigation.

PMID: 12113324 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------
Who loves ya.
Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

http://tinyurl.com/6axwp

Acta Cirurgica Brasileira
Print ISSN 0102-8650

Acta Cir. Bras. vol.19 no.3 São Paulo May/June 2004
The effects of topical application of sunflower-seed oil on open wound
healing in lambs1

The present work showed by morphometrical, clinical and histological
assays that sunflower-seed oil improved the granulation tissue
formation and epithelial resurfacing of wounds. Therefore,
sunflower-seed oil or other vegetable oils containing a high
concentration of linoleic acid, can be indicated as a therapeutic
alternative for wound healing process by second intention in veterinary
medicine

Who loves ya.
Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

They abstracts you cite only talk about fatty acids having effects upon the
dermis. Whether the fat gets any farther than the dermis is not as well
established. Certainly there seems to be some fatty acids making it into the
central circulation, but most probably remains trapped in the dermis (which
seems to be what you are looking for). Fats are mostly absorped and
transported by the lymphatic system, and I do not think that there is much
lymph drainage from the dermis.

K F
<[email hidden]> wrote in message
news:[email hidden]...
http://tinyurl.com/6axwp

Acta Cirurgica Brasileira
Print ISSN 0102-8650

Acta Cir. Bras. vol.19 no.3 So Paulo May/June 2004
The effects of topical application of sunflower-seed oil on open wound
healing in lambs1

The present work showed by morphometrical, clinical and histological
assays that sunflower-seed oil improved the granulation tissue
formation and epithelial resurfacing of wounds. Therefore,
sunflower-seed oil or other vegetable oils containing a high
concentration of linoleic acid, can be indicated as a therapeutic
alternative for wound healing process by second intention in veterinary
medicine

Who loves ya.
Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking