General fitness, health and nutrition · Public discussion

Thalassemia / tocopherol / vitamin E

Doe · 2004-03-30T16:47:07+00:00

Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related Articles, Links Attenuation of oxidative stress-induced changes in thalassemic erythrocytes by vitamin E. Das N, Chowdhury TD, Chattopadhyay A, Datta AG. Department of Life Science and Biotechnology, Jadavpur University, Kolkata - 700 032, India. [email hidden]; [email hidden] The oxidative stress status of the transfusion-dependant Ebeta- and beta-thalassemia patients were studied before and after treatment with vitamin E for a period of four weeks. The level of cellular vitamin antioxidants viz. ascorbic acid and vitamin E in the thalassemia patients were found to be considerably lower compared to normal subjects. The activities of enzymatic antioxidants viz. catalase, glutathione peroxidase and glutathione reductase were found to be drastically reduced in untreated Ebeta- and beta- thalassemic patients when compared to normal subjects. However, the activity of superoxide dis-mutase was found to be increased in both types of untreated thalassemic patients when compared to normal individuals. An increase in superoxide dismutase and a decrease in catalase activity reflects the presence of a severe oxidative stress situation in the erythrocytes of the untreated transfusion dependant Ebeta- and beta-thalassemia patients. Changes in erythrocyte membrane protein pattern in untreated Ebeta- and beta- thalassemia patients when compared to normal erythrocyte further confirm the presence of continued oxidative stress in the ailing thalassemic erythrocytes. All these changes in the antioxidant status as well as the changes in the erythrocyte membrane proteins are ameliorated to considerable extent when the transfusion-dependent Ebeta- and beta-thalassemia patients were treated with vitamin E at a dose of 10 mg/kg/day for a period of four weeks. The patients during the treatment period did not exhibit any side effects and gained in body weight indicating a healthy status. The present study reveals that the lipophilic antioxidant vitamin E could be useful in the management of transfusion- dependant Ebeta- and beta-thalassemia patients. PMID: 15047982 [PubMed - in process] ------------------------------------------------------------ -------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

Started by Doe · 30 March 2004 · Last activity 30 March 2004 · 10 posts · 516 views

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Original section: General fitness, health and nutrition
Published: 30 March 2004
Last activity: 30 March 2004
Original author: Doe
Posts: 10
Discussion status: Public discussion
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Original post
Doe
Archived post

30 March 2004, 16:47 UTC #1

Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related Articles, Links
Attenuation of oxidative stress-induced changes in
thalassemic erythrocytes by vitamin E.
Das N, Chowdhury TD, Chattopadhyay A, Datta AG.
Department of Life Science and Biotechnology, Jadavpur
University, Kolkata - 700 032, India. [email hidden];
[email hidden]
The oxidative stress status of the transfusion-dependant Ebeta-
and beta-thalassemia patients were studied before and after
treatment with vitamin E for a period of four weeks. The
level of cellular vitamin antioxidants viz. ascorbic acid
and vitamin E in the thalassemia patients were found to be
considerably lower compared to normal subjects. The
activities of enzymatic antioxidants viz. catalase,
glutathione peroxidase and glutathione reductase were found
to be drastically reduced in untreated Ebeta- and beta-
thalassemic patients when compared to normal subjects.
However, the activity of superoxide dis-mutase was found to
be increased in both types of untreated thalassemic patients
when compared to normal individuals. An increase in
superoxide dismutase and a decrease in catalase activity
reflects the presence of a severe oxidative stress situation
in the erythrocytes of the untreated transfusion dependant
Ebeta- and beta-thalassemia patients. Changes in erythrocyte
membrane protein pattern in untreated Ebeta- and beta-
thalassemia patients when compared to normal erythrocyte
further confirm the presence of continued oxidative stress
in the ailing thalassemic erythrocytes. All these changes in
the antioxidant status as well as the changes in the
erythrocyte membrane proteins are ameliorated to
considerable extent when the transfusion-dependent Ebeta-
and beta-thalassemia patients were treated with vitamin E at
a dose of 10
mg/kg/day for a period of four weeks. The patients during
the treatment period did not exhibit any side effects and
gained in body weight indicating a healthy status. The
present study reveals that the lipophilic antioxidant
vitamin E could be useful in the management of transfusion-
dependant Ebeta- and beta-thalassemia patients.
PMID: 15047982 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com Man Is A Herbivore!
pages.ivillage.commanisaherbivore DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalking

Report
markd
Archived post

30 March 2004, 17:06 UTC #2

And what exactly are we to make of this, how does it relate
to any body of theory, to what practical use is it, and to
what goal can it be useful? Without this information it is
but another random abstract plucked from the web, one among
thousands of such.

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Doe
Archived post

30 March 2004, 17:46 UTC #3

Quoted message said:
Subject: Re: Thalassemia / tocopherol / vitamin E
From: [email hidden]
Date: 3/30/2004 9:44 AM Mountain Standard Time
Message-id: <[email hidden]>
And what exactly are we to make of this, how does it relate
to any body of theory, to what practical use is it, and to
what goal can it be useful? Without this information it is
but another random abstract plucked from the web, one among
thousands of such.
Jeez .. can't even understand a simple medical study ..?
Right after the word .. 'conclusion' .. comes this phrase ..
vitamin E could be useful in the management of transfusion-
dependant Ebeta- and beta-thalassemia patients
Little advice .. right after .. the .. word .. conclusion ..
in .. a .. medical .. study .. comes .. some .. important ..
relevant .. information .. pertaining .. to .. the ..
medical .. study ..
Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related
Articles, Links
Attenuation of oxidative stress-induced changes in
thalassemic erythrocytes by vitamin E.
Das N, Chowdhury TD, Chattopadhyay A, Datta AG.
Department of Life Science and Biotechnology, Jadavpur
University, Kolkata - 700 032, India. [email hidden];
[email hidden]
The oxidative stress status of the transfusion-dependant Ebeta-
and beta-thalassemia patients were studied before and after
treatment with vitamin E for a period of four weeks. The
level of cellular vitamin antioxidants viz. ascorbic acid
and vitamin E in the thalassemia patients were found to be
considerably lower compared to normal subjects. The
activities of enzymatic antioxidants viz. catalase,
glutathione peroxidase and glutathione reductase were found
to be drastically reduced in untreated Ebeta- and beta-
thalassemic patients when compared to normal subjects.
However, the activity of superoxide dis-mutase was found to
be increased in both types of untreated thalassemic patients
when compared to normal individuals. An increase in
superoxide dismutase and a decrease in catalase activity
reflects the presence of a severe oxidative stress situation
in the erythrocytes of the untreated transfusion dependant
Ebeta- and beta-thalassemia patients. Changes in erythrocyte
membrane protein pattern in untreated Ebeta- and beta-
thalassemia patients when compared to normal erythrocyte
further confirm the presence of continued oxidative stress
in the ailing thalassemic erythrocytes. All these changes in
the antioxidant status as well as the changes in the
erythrocyte membrane proteins are ameliorated to
considerable extent when the transfusion-dependent Ebeta-
and beta-thalassemia patients were treated with vitamin E at
a dose of 10
mg/kg/day for a period of four weeks. The patients during
the treatment period did not exhibit any side effects and
gained in body weight indicating a healthy status. The
present study reveals that the lipophilic antioxidant
vitamin E could be useful in the management of transfusion-
dependant Ebeta- and beta-thalassemia patients.
PMID: 15047982 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com Man Is A Herbivore!
pages.ivillage.commanisaherbivore DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalking

Report
markd
Archived post

30 March 2004, 17:46 UTC #4

Ah, so when you are a doc you can use this for
transfusions,ie. increasing the iron level by introducing it
externally? A very clever approach to iron anemia indeed,
why didn't I think of that?

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Doe
Archived post

30 March 2004, 18:15 UTC #5

Quoted message said:
Subject: Re: Thalassemia / tocopherol / vitamin E
From: [email hidden]
Date: 3/30/2004 10:13 AM Mountain Standard Time
Message-id: <[email hidden]>
Ah, so when you are a doc you can use this for
transfusions,ie. increasing the iron level by introducing
it externally?
No .. it .. simply .. CONFIRMS .. a lack of tocopherol in
thalassemia patients ..
Pretty straight forward and easy to understand ..
actually ..
YOU .. though .. somehow miss this ..
Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related
Articles, Links
Attenuation of oxidative stress-induced changes in
thalassemic erythrocytes by vitamin E.
Das N, Chowdhury TD, Chattopadhyay A, Datta AG.
Department of Life Science and Biotechnology, Jadavpur
University, Kolkata - 700 032, India. [email hidden];
[email hidden]
The oxidative stress status of the transfusion-dependant Ebeta-
and beta-thalassemia patients were studied before and after
treatment with vitamin E for a period of four weeks. The
level of cellular vitamin antioxidants viz. ascorbic acid
and vitamin E in the thalassemia patients were found to be
considerably lower compared to normal subjects. The
activities of enzymatic antioxidants viz. catalase,
glutathione peroxidase and glutathione reductase were found
to be drastically reduced in untreated Ebeta- and beta-
thalassemic patients when compared to normal subjects.
However, the activity of superoxide dis-mutase was found to
be increased in both types of untreated thalassemic patients
when compared to normal individuals. An increase in
superoxide dismutase and a decrease in catalase activity
reflects the presence of a severe oxidative stress situation
in the erythrocytes of the untreated transfusion dependant
Ebeta- and beta-thalassemia patients. Changes in erythrocyte
membrane protein pattern in untreated Ebeta- and beta-
thalassemia patients when compared to normal erythrocyte
further confirm the presence of continued oxidative stress
in the ailing thalassemic erythrocytes. All these changes in
the antioxidant status as well as the changes in the
erythrocyte membrane proteins are ameliorated to
considerable extent when the transfusion-dependent Ebeta-
and beta-thalassemia patients were treated with vitamin E at
a dose of 10
mg/kg/day for a period of four weeks. The patients during
the treatment period did not exhibit any side effects and
gained in body weight indicating a healthy status. The
present study reveals that the lipophilic antioxidant
vitamin E could be useful in the management of transfusion-
dependant Ebeta- and beta-thalassemia patients.
PMID: 15047982 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom
Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com
Man Is A Herbivore!
pages.ivillage.commanisaherbivore DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalking

Report
markd
Archived post

30 March 2004, 18:26 UTC #6

Smile, Tom I didn't miss it at all. I could not resist
to once again tinkle your bell, I'm so weak to resist
temptation. But you must agree, to reuce iron anemia
rapidly, transfusions are a way to go. On the other
hand, just think of all that good vit e one loses at the
blood bank.

Report
Doe
Archived post

30 March 2004, 18:26 UTC #7

Quoted message said:
Subject: Re: Thalassemia / tocopherol / vitamin E
Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related
Articles, Links
Attenuation of oxidative stress-induced changes in
thalassemic erythrocytes by vitamin E.
Das N, Chowdhury TD, Chattopadhyay A, Datta AG.
Department of Life Science and Biotechnology, Jadavpur
University, Kolkata - 700 032, India. [email hidden];
[email hidden]
The oxidative stress status of the transfusion-dependant Ebeta-
and beta-thalassemia patients were studied before and after
treatment with vitamin E for a period of four weeks. The
level of cellular vitamin antioxidants viz. ascorbic acid
and vitamin E in the thalassemia patients were found to be
considerably lower compared to normal subjects. The
activities of enzymatic antioxidants viz. catalase,
glutathione peroxidase and glutathione reductase were found
to be drastically reduced in untreated Ebeta- and beta-
thalassemic patients when compared to normal subjects.
However, the activity of superoxide dis-mutase was found to
be increased in both types of untreated thalassemic patients
when compared to normal individuals. An increase in
superoxide dismutase and a decrease in catalase activity
reflects the presence of a severe oxidative stress situation
in the erythrocytes of the untreated transfusion dependant
Ebeta- and beta-thalassemia patients. Changes in erythrocyte
membrane protein pattern in untreated Ebeta- and beta-
thalassemia patients when compared to normal erythrocyte
further confirm the presence of continued oxidative stress
in the ailing thalassemic erythrocytes. All these changes in
the antioxidant status as well as the changes in the
erythrocyte membrane proteins are ameliorated to
considerable extent when the transfusion-dependent Ebeta-
and beta-thalassemia patients were treated with vitamin E at
a dose of 10
mg/kg/day for a period of four weeks. The patients during
the treatment period did not exhibit any side effects and
gained in body weight indicating a healthy status. The
present study reveals that the lipophilic antioxidant
vitamin E could be useful in the management of transfusion-
dependant Ebeta- and beta-thalassemia patients.
PMID: 15047982 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com Man Is A Herbivore!
pages.ivillage.commanisaherbivore DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalking

Report
markd
Archived post

30 March 2004, 19:46 UTC #8

Folk who need blood transfusions for a specific disease do
better when vits c e are provided. People who give blood
have less of everything that isgood in blood.

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Doe
Archived post

30 March 2004, 21:43 UTC #9

Quoted message said:
Subject: Re: Thalassemia / tocopherol / vitamin E
From: [email hidden]
Date: 3/30/2004 12:12 PM Mountain Standard Time
Message-id: <[email hidden]>
Folk who need blood transfusions for a specific disease do
better when vits c e are provided.
Very .. good ..
Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related
Articles, Links
Attenuation of oxidative stress-induced changes in
thalassemic erythrocytes by vitamin E.
Das N, Chowdhury TD, Chattopadhyay A, Datta AG.
Department of Life Science and Biotechnology, Jadavpur
University, Kolkata - 700 032, India. [email hidden];
[email hidden]
The oxidative stress status of the transfusion-dependant Ebeta-
and beta-thalassemia patients were studied before and after
treatment with vitamin E for a period of four weeks. The
level of cellular vitamin antioxidants viz. ascorbic acid
and vitamin E in the thalassemia patients were found to be
considerably lower compared to normal subjects. The
activities of enzymatic antioxidants viz. catalase,
glutathione peroxidase and glutathione reductase were found
to be drastically reduced in untreated Ebeta- and beta-
thalassemic patients when compared to normal subjects.
However, the activity of superoxide dis-mutase was found to
be increased in both types of untreated thalassemic patients
when compared to normal individuals. An increase in
superoxide dismutase and a decrease in catalase activity
reflects the presence of a severe oxidative stress situation
in the erythrocytes of the untreated transfusion dependant
Ebeta- and beta-thalassemia patients. Changes in erythrocyte
membrane protein pattern in untreated Ebeta- and beta-
thalassemia patients when compared to normal erythrocyte
further confirm the presence of continued oxidative stress
in the ailing thalassemic erythrocytes. All these changes in
the antioxidant status as well as the changes in the
erythrocyte membrane proteins are ameliorated to
considerable extent when the transfusion-dependent Ebeta-
and beta-thalassemia patients were treated with vitamin E at
a dose of 10
mg/kg/day for a period of four weeks. The patients during
the treatment period did not exhibit any side effects and
gained in body weight indicating a healthy status. The
present study reveals that the lipophilic antioxidant
vitamin E could be useful in the management of transfusion-
dependant Ebeta- and beta-thalassemia patients.
PMID: 15047982 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com Man Is A Herbivore!
pages.ivillage.commanisaherbivore DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalking

Report
markd
Archived post

30 March 2004, 23:23 UTC #10

So Tom, are you planning to have transfusions in the near
future, otherwise what is the purpose of posting the
abstract, the original question? Remember, all the good
things in blood is lost when giving blood.

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