Quoted message said:
Does the deposition of iron / hemolysis / red blood cell destruction
... during normal day to day wear and tear .. deposit .. hemosiderin /
iron .. long term storage form of iron .. which causes destruction ..
hence the use of iron binding pain killers such as .. aspirin .. ?
This hemosiderin would .. normally .. be taken away and made into new
red blood cells .. BUT .. when abnormal levels of iron exist the iron
just becomes .. hemosiderin .. instead .. and deposits .. itself.
sid·er·o·phore (sdr--fôr)
n.
A large, extravasated, mononuclear phagocyte containing a granule of
hemosiderin. Also called siderophage.
<<snip>>
small foci with iron positive haemosiderophages, indicating prior
microtraumatic events, were found in 6/10 samples
<<snip>>
Ann Rheum Dis. 2005 Jul;64(7):1083-6. Related Articles, Links
Achilles tendinosis is associated with sprouting of substance P
positive nerve fibres.
Schubert TE, Weidler C, Lerch K, Hofstadter F, Straub RH.
Department of Pathology, Franz-Josef-Strauss-Allee 11, 93053
Regensburg, Germany. [email hidden]ensburg.de.
OBJECTIVES: To identify and characterise nerve fibres and inflammatory
alterations in painful Achilles tendinosis and thus gain evidence about
the origin of pain in Achilles tendinosis. METHODS: The composition of
10 tendon samples from patients with a prior history of painful
Achilles tendinosis and 10 samples from patients with spontaneously
ruptured tendons but no previous pain was compared by
immunohistochemistry and conventional histology. RESULTS: The presence
of granulation tissue was shown in 8/10 cases of Achilles tendinosis.
Nociceptive substance P (SP) positive nerve fibres were significantly
increased, and an inflammatory infiltration comprising B and T
lymphocytes was found. Additionally, small foci with iron positive
haemosiderophages, indicating prior microtraumatic events, were found
in 6/10 samples. None of the spontaneously ruptured tendons contained
granulation tissue or haemosiderophages. Inflammatory infiltration in
these patients consisted almost exclusively of granulocytes and SP
positive nerve fibres were decreased. The density of sympathetic nerve
fibres did not differ in the two conditions. CONCLUSION: Achilles
tendinosis is associated with the presence of granulation tissue,
haemosiderophages, and SP positive nerve fibres, which may transmit the
clinically pertinent pain. Achilles tendinosis may be caused by
repeated microtraumata with ensuing organisation that is accompanied by
sprouting of nociceptive SP positive nerve fibres.
PMID: 15958764 [PubMed - in process]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
<