Septicaemia

Quoted message said:

Subject: Septicaemia
From: [email hidden] (N. Thornton)
Date: 2/15/2004 7:05 PM Mountain Standard Time
Message-id: <[email hidden]>

Hi

Any heads up on this could prove very helpful.

The situation is: Septicaemia, plus a few local infections, CD4 count zero, infections have not
responded to the first wave of hospital antibiotic treatment.

If theres anything I should know that might be usable to make a difference to the outcome in any
way, please let me know. I'll check this in the morning.

Thanks, NT

Best Pract Res Clin Haematol 2002 Jun;15(2):411-26

Iron and infection: competition between host and microbes for a precious element.

Marx JJ Eijkman-Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University
Medical Centre Utrecht,
G04.614, PO Box 85500, 3508 GA Utrecht, The Netherlands.

During infection microbes attack host tissues, causing damage to specific organs, sepsis or even
death. For proliferation microbes desperately need iron for which they have to compete with the
host. Micro-organisms have developed an abundant number of strategies to acquire iron from their
specific environment and to transport the element to sites of incorporation into biologically
important molecules. As part of the non-specific defence mechanisms against infection, the body
modifies iron metabolism in order to make iron less available for micro-organisms. Such processes
have a profound effect on the immune system and are also expressed in other forms of inflammation.
Microbial iron transport systems are explored as targets for antibiotic treatment and vaccines. In
particular, iron chelators, used for the treatment of iron overload may become important drugs for
fighting bacterial and viral infections.

PMID: 12401315, UI: 22288772

----------------------------------------------
.

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Quoted message said:

Subject: Septicaemia
From: [email hidden] (N. Thornton)
Date: 2/15/2004 7:05 PM Mountain Standard Time
Message-id: <[email hidden]>

Hi

Any heads up on this could prove very helpful.

The situation is: Septicaemia, plus a few local infections, CD4 count zero, infections have not
responded to the first wave of hospital antibiotic treatment.

If theres anything I should know that might be usable to make a difference to the outcome in any
way, please let me know. I'll check this in the morning.

Thanks, NT

In extreme cases of infection .. periotonitis .. they have found by the infusion of 'bleach' .. into
the body cavity greatly reduces the septicaemia ..

Cost ? about 55 cents ..

Who loves ya. Tom

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[email hidden] (doe) wrote in message news:<[email hidden]>...

Nt said:

Quoted message said:

Any heads up on this could prove very helpful.

The situation is: Septicaemia, plus a few local infections, CD4 count zero, infections have not
responded to the first wave of hospital antibiotic treatment.

If theres anything I should know that might be usable to make a difference to the outcome in any
way, please let me know. I'll check this in the morning.

Quoted message said:

In extreme cases of infection .. periotonitis .. they have found by the infusion of 'bleach' ..
into the body cavity greatly reduces the septicaemia ..

This piece describes it as a bad bad idea:

jpgmonline.comarticle.aspOpen ↗
3859;year=1994;volume=40;issue=3;spage=179;epage=84;aulast=Shetty

Do you have other info?

Thanks, NT

[email hidden] (doe) wrote in message news:<[email hidden]>...

Quoted message said:

Quoted message said:

Subject: Re: Septicaemia

Quoted message said:

Anesteziol Reanimatol. 2001 Mar-Apr;(2):48-51. Related Articles, Links

[Electrochemical detoxication of the lymph in the treatment of patients with suppurative-
resorptive endotoxicosis]

[Article in Russian]

Fedoseev AV, Tarasenko SV, Zaitsev OV.

A new method for lymph detoxication in patients with pyoresorptive endotoxicosis is proposed. The
method is based on electrochemical oxidation of the lymph, is simple and cheap. After 4-h exposure
of the lymph with 0.04% sodium hypochlorite the concentration of the main toxic metabolites
appreciably decreased, while the levels of total protein and leukocytes changed negligibly.
Electrochemical detoxication of the lymph was used in the treatment of 13 patients with
pyoresorptive endotoxicosis and led to improvement of the clinical status and rapid decrease in
the levels of the major toxic metabolites, which was particularly expressed 3 days after the
treatment. No negative effects were observed. Hence, electrochemical detoxication of the lymph
appreciably improved the results of treatment of patients with cholestatic endotoxicosis.

PMID: 11494902 [PubMed - indexed for MEDLINE]

Excellant stuff Tom, thank you. I found stacks more articles on several promising techniques: when
this time is past I'll post them for everyone.

Cheers! NT

[email hidden] (N. Thornton) wrote in message news:<[email hidden]>...

Quoted message said:

Hi

Any heads up on this could prove very helpful.

The situation is: Septicaemia, plus a few local infections, CD4 count zero, infections have not
responded to the first wave of hospital antibiotic treatment.

If theres anything I should know that might be usable to make a difference to the outcome in any
way, please let me know. I'll check this in the morning.

Thanks, NT

Any more input on this would be very welcome, this is still an ongoing situation.

Thanks, NT

N. Thornton said:

Hi

Any heads up on this could prove very helpful.

The situation is: Septicaemia, plus a few local infections, CD4 count zero, infections have not
responded to the first wave of hospital antibiotic treatment.

If theres anything I should know that might be usable to make a difference to the outcome in any
way, please let me know. I'll check this in the morning.

Thanks, NT

You've posted about a cat and abscess, a wound healing on someone's back and other infection related
posts. How about more details? wrongdiagnosis.comcauses.htmOpen ↗
wrongdiagnosis.comintro.htmOpen ↗ J

J <[email hidden]> wrote in message news:<[email hidden]>...

Quoted message said:

"N. Thornton" wrote:

Quoted message said:

Quoted message said:

The situation is: Septicaemia, plus a few local infections, CD4 count zero, infections have not
responded to the first wave of hospital antibiotic treatment.

If theres anything I should know that might be usable to make a difference to the outcome in any
way, please let me know. I'll check this in the morning.

Quoted message said:

You've posted about a cat and abscess, a wound healing on someone's back and other infection
related posts. How about more details?

OK. An experimental last ditch treatment involved killing all CD4 cells and all bone marrow. This is
human, not cat. Bone marrow was then transplanted back to regnerate the immune system. While the
treament seemed successful initially, the first bone marrow transplant failed. The patient now has a
zero CD4 count and has developed septicaemia. The septicaemia has been treated with antibiotics IV
and direct into the spinal fluid. However the level of infection has not improved, the bacteria are
antibiotic resistant. A second bone marrow transplant can not be done unless the septicaemia is
resolved first.

So we're now getting into experimental treatments that show promising results, and last ditch
treatment options. Desferrioxamin and vitamin E are now being tried in addition to the antibiotics.
From the study quoted earlier in this thread:

Rats treated with antibiotics alone (Group 5) had a mortality rate of 40%. Those treated with a
combination of antibiotics and vitamin E (Group
7), however, had a mortality rate of only 14%, and those treated with antibiotics and Dfx had a
mortality rate of only 7%.

At the moment I'm searching for all potential treatment options, we need to pull something out of
the hat here, if in any way possible. So far I've looked at studies on:

Opebecan Protein C Teicoplanin desferrioxamin vitamin E antioxidants sodium hypochlorite BPI21
Cecropin B colloidal silver - report, no study, would like a proper study on this one. garlic
plasmapheresis and leaucapheresis blood exchange

Current treatment is:

antibiotics IV antibiotics into the CSF ventilation blood exchange vitamin E desferrioxamin

The treatment is in the hands of a research team, I'm searching for any studies on any techniques
that are worth trying here. Given the extremity of the situation, rat-based studies are enough to
work on when all else has failed.

If there are any techniques I've missed here, or anything else, I'm all ears.

Thanks, NT

[email hidden] (N. Thornton) wrote in message news:<a7076635.0402210404.

Quoted message said:

Quoted message said:

Quoted message said:

The situation is: Septicaemia, plus a few local infections, CD4 count zero, infections have
not responded to the first wave of hospital antibiotic treatment.

If theres anything I should know that might be usable to make a difference to the outcome in
any way, please let me know. I'll check this in the morning.

Quoted message said:

OK. An experimental last ditch treatment involved killing all CD4 cells and all bone marrow. This
is human, not cat. Bone marrow was then transplanted back to regnerate the immune system. While
the treament seemed successful initially, the first bone marrow transplant failed. The patient now
has a zero CD4 count and has developed septicaemia. The septicaemia has been treated with
antibiotics IV and direct into the spinal fluid. However the level of infection has not improved,
the bacteria are antibiotic resistant. A second bone marrow transplant can not be done unless the
septicaemia is resolved first.

So we're now getting into experimental treatments that show promising results, and last ditch
treatment options. Desferrioxamin and vitamin E are now being tried in addition to the
antibiotics. From the study quoted earlier in this thread:

Rats treated with antibiotics alone (Group 5) had a mortality rate of 40%. Those treated with a
combination of antibiotics and vitamin E (Group
7), however, had a mortality rate of only 14%, and those treated with antibiotics and Dfx had a
mortality rate of only 7%.

At the moment I'm searching for all potential treatment options, we need to pull something out of
the hat here, if in any way possible. So far I've looked at studies on:

Opebecan Protein C Teicoplanin desferrioxamin vitamin E antioxidants sodium hypochlorite BPI21
Cecropin B colloidal silver - report, no study, would like a proper study on this one. garlic
plasmapheresis and leaucapheresis blood exchange

Current treatment is:

antibiotics IV antibiotics into the CSF ventilation blood exchange vitamin E desferrioxamin

The treatment is in the hands of a research team, I'm searching for any studies on any techniques
that are worth trying here. Given the extremity of the situation, rat-based studies are enough to
work on when all else has failed.

If there are any techniques I've missed here, or anything else, I'm all ears.

Thanks, NT

OK, the infections are: Neisseria meningitidis (meningococcus) Staphylococcus aureus

Regards, NT

Quoted message said:

Subject: Re: Septicaemia
From: [email hidden] (N. Thornton)
Date: 2/20/2004 3:45 PM Mountain Standard Time
Message-id: <[email hidden]>

[email hidden] (N. Thornton) wrote in message
news:<[email hidden]>...

Quoted message said:

Hi

Any heads up on this could prove very helpful.

The situation is: Septicaemia, plus a few local infections, CD4 count zero, infections have not
responded to the first wave of hospital antibiotic treatment.

If theres anything I should know that might be usable to make a difference to the outcome in any
way, please let me know. I'll check this in the morning.

Thanks, NT

Any more input on this would be very welcome, this is still an ongoing situation.

Thanks, NT

medscape.com410024Open ↗

The Potential of Bismuth-Thiols for Treatment and Prevention of Infection

You may wish to do a search of lactoferrin and here is a recent article ..

medscape.com464466Open ↗

Who loves ya. Tom Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

[email hidden] (doe) wrote in message news:<[email hidden]>...

Quoted message said:

medscape.com410024Open ↗

The Potential of Bismuth-Thiols for Treatment and Prevention of Infection

You may wish to do a search of lactoferrin and here is a recent article ..

medscape.com464466Open ↗

Who loves ya. Tom

Great, I'll get onto that now. The links dont yield anything readable, but I'll search on
the keywords.

Thanks! NT

[email hidden] (N. Thornton) wrote in message news:<[email hidden]>...

Quoted message said:

[email hidden] (doe) wrote in message news:<20040301054501.06534.

Quoted message said:

Quoted message said:

You may wish to do a search of lactoferrin and here is a recent article ..

medscape.com464466Open ↗

Quoted message said:

Great, I'll get onto that now. The links dont yield anything readable, but I'll search on the
keywords.

Thanks! NT

OK I turned up plenty on bismuth thiols, but not lactoferrin. Lactoferrin yielded page after page of
rubbish. The medscape articles arent accessible: do you have any other leads on this?

Thanks, NT