Reversion of iron-induced memory impairment

Exp Neurol. 2005 Aug 23; [Epub ahead of print] Related Articles, Links

Selegiline protects against recognition memory impairment induced by
neonatal iron treatment.

de Lima MN, Laranja DC, Caldana F, Grazziotin MM, Garcia VA, Dal-Pizzol
F, Bromberg E, Schroder N.

Programa de Pos-Graduacao em Gerontologia Biomedica, Instituto de
Geriatria e Gerontologia, Hospital Sao Lucas, Pontificia Universidade
Catolica do Rio Grande do Sul, 90619-900 Porto Alegre, RS, Brazil.

Excess of iron in the brain has been implicated in the pathogenesis of
several human neurodegenerative diseases, for example Alzheimer's
disease and Parkinson's disease. It has been shown that the neonatal
period is critical for the establishment of normal iron content in the
adult brain. Moreover, it is known that aging alters the cerebral
distribution of this metal. We have recently described that neonatal
administration of iron severely impaired novel object recognition
memory in rats. The aim of the present study was to determine whether
selegiline, a monoamine oxidase (MAO) inhibitor known for its
neuroprotective properties, could protect rats against cognitive
impairment induced by neonatal administration of iron. In the first
experiment, male Wistar rats received vehicle (5% sorbitol in water) or
iron (10.0 mg/kg) orally from postnatal days 12 to 14 and saline (0.9%
NaCl) or selegiline (1.0 or 10.0 mg/kg) intraperitoneally for 21 days,
starting 24 h before the first iron dosing. In the second experiment,
rats were given either vehicle or iron (10.0 mg/kg) orally from
postnatal days 12 to 14 followed by saline or selegiline (1.0 or 10.0
mg/kg) intraperitoneally for 21 days, starting when rats reached
adulthood (50th day after birth). Iron-treated rats given selegiline in
both doses showed no deficits in recognition memory. Rats receiving
iron but no selegiline presented memory deficits. This is the first
study reporting the reversion of iron-induced memory impairment,
supporting the view that our model can be considered as a useful tool
in the search for new drugs with neuroprotective and/or memory
enhancing properties.

PMID: 16122736 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

What the article .. says .. since you can't OBVIOUSLY .. understand ..
IS .. iron induces memory impariment ..

<<snip>>
This is the first
study reporting the reversion of iron-induced memory impairment
<<snip>>

Is that .. REALLY .. that .. HARD .. to .. understand .. ?

Must be ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

My reply was in the context of the larger picture of iron level and mental
disorders. If one limits oneself to an unrelated patchwork of individual
narrowly focused research studies this larger picture is lost. For all
nutritional substances, including iron, there is a minimal, an optimal,
and a max amount that relate to it's effects in human health. On the low
end mental problems result, as do they on the over max end; which was the
example the study posted shows. On balance, far more of the world's
population have too little which makes it the number one health problem
because of the mental health problems it causes in children that persist
into aadulthood.

And how many groups are you crossposting to now, Ironhead?

Sheesh, people like you are like a virus. . .

Sylvia

On 27 Aug 2005 09:07:52 -0700, "[email hidden]"
<[email hidden]> wrote in alt.support.mult-sclerosis:

See the difference between an abstract and the full article
at http://www.pedresearch.org/cgi/content/full/55/6/1034 .
It is primarily about deafness in neonatals, but also
mentions cognition due to too little iron.

The web has many articles dealing with cognition or deafness
in perinatals caused by lack of iron in the diet. Tommy
would have us believe that he knows all this, so we can only
speculate on why he posts what he knows to be inaccurate
abstracts.

Cue Tommy's swearing...
--
Spelling and grammatical errors are deliberate
to catch copyright violators. ©¿©¬
Perth, Ontario, Canada

"Sylv" <[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

And how many groups are you crossposting to now, Ironhead?

Sheesh, people like you are like a virus. . .

Way too much credit!

Quoted message said:

Quoted message said:

so we can only
speculate on why he posts what he knows to be inaccurate
abstracts.

<<

I say .. iron deficiency .. doesn't .. exist .. in a FED society ..

Studies seem to support this .. theory ..

YOU and your 'ilk' .. continuously wish to refer to studies in which
the study groups are comprised of .. in many cases .. severely
malnourished and/or 'slightly' impoverished ..

I prefer to refer to studies in which the population is .. fed ..

Why would I .. care .. whether some starving .. person .. shows signs
of .. anemia .. ? cognition .. ?

It doesn't .. relate ..

WHEREAS .. evidence based medicine .. shows CLEARLY .. the EFFICACY ..
of .. iron deprivation / reduction / limitation .. IN .. disease states
...

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

On 27 Aug 2005 22:03:52 -0700, "[email hidden]"
<[email hidden]> wrote in alt.support.mult-sclerosis:

Quoted message said:

WHEREAS .. evidence based medicine .. shows CLEARLY .. the EFFICACY ..
of .. iron deprivation / reduction / limitation .. IN .. disease states
..

So...

You want to take our normally fed society and withdraw iron
from our diet so that we can have a society that is deaf and
has cognition problems in addition to whatever other disease
we might have. Why? Study after STUDY shows CLEARLY that
YOU, YES, YOU, do NOT KNOW what YOU are talking about. Look
it up.

You are just road kill on the information highway: two eyes
flashing in the headlights of a speeding truck and then
SPLAT! Another stinking carcass to become fertiliser for
the weeds beside the road.
---
From: doe ([email hidden])
Newsgroup: Sci.med Date: 2002-10-13 18:14:20 PST
[snip]
That would make you even more clueless than me .. or can't you
understand that

On 28 Aug 2005 Jim Carter said:

On 27 Aug 2005 22:03:52 -0700, "[email hidden]"
<[email hidden]> wrote in alt.support.mult-sclerosis:

Quoted message said:

WHEREAS .. evidence based medicine .. shows CLEARLY .. the EFFICACY ..
of .. iron deprivation / reduction / limitation .. IN .. disease states
..

So...

You want to take our normally fed society and withdraw iron
from our diet so that we can have a society that is deaf and
has cognition problems in addition to whatever other disease
we might have. Why? Study after STUDY shows CLEARLY that
YOU, YES, YOU, do NOT KNOW what YOU are talking about. Look
it up.

Oh, dear, can't you just ignore him, in the way that most of us do?

With best wishes,

Peter.

--
Peter \ / \ Prestbury, Cheltenham, Glos. GL52
Anne \ / __ __ \ England.
and / / \ | | |\ | / _ \ http://pnyoung.orpheusweb.co.uk
family / \__/ \_/ | \| \__/ \______________ [email hidden].

Quoted message said:

Quoted message said:

You want to take our normally fed society and withdraw iron

from our diet so that we can have a society that is deaf and
has cognition problems in addition to whatever other disease
we might have. <<

So .. smart .. guy ..

Off the topic of your fat fkg head .. what diet WOULD .. disallow the
intake of iron .. below .. what .. is NECESSARY ..

Come on ...

Shouldn't be hard ..

Since you and others believe there IS a diet .. devoid of iron ..

Three squares .. a .. day ..

Devise .. one ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

intake of iron .. below .. what .. is NECESSARY .."

Easy, the natural experiment showing this is worldwid and easy to observe.
Where a mainly vegetarian diet with only a few items are eaten on an
ongo8ing basis the problem of low iron is the standard situation. This is
the root cause of low iron in children and women being the world's number
one health problem. If one eats a mainly vegetarian diet one must take
measures to be sure to include items with enough iron and in a form that
can be absorbed readily and isn't in conflict with other foods which
inhibit absorbtion. Diets high in milled grains are the main culpret
because they are cheap enough for people to afford, this is different from
problems from starvation, it's about eating too much os a few kinds of
foods. .

You can eat a vegetarian diet and get enough iron from plant sources;
I've been doing it for over 30 years.

And, to Ironhead's eternal chagrin, you can also get MS on such a diet.
.. .I'm living proof that he is full of horsehockey. But anyone
familiar with his rantings does not need any proof of that!

Sylvia

Actually .. this article seems to say .. even a HIGH .. meat based ..
diet .. does not allow one access to enough iron to .. constitute ..
ENOUGH .. iron .. in the diet .. or what .. they .. have decided to BE
... sufficient .. iron ..

We're .. all .. fkd ..

Or so they would have us .. believe ..

1: Br J Nutr. 2005 Jul;94(1):78-83. Related Articles, Links

Pork meat increases iron absorption from a 5-day fully controlled diet
when compared to a vegetarian diet with similar vitamin C and phytic
acid content.

Bach Kristensen M, Hels O, Morberg C, Marving J, Bugel S, Tetens I.

Department of Human Nutrition, Centre for Advanced Food Studies (LMC),
The Royal Veterinary and Agricultural University, Frederiksberg,
Denmark.

Meat increases absorption of non-haem iron in single-meal studies. The
aim of the present study was to investigate, over a 5 d period, the
potential increasing effect of consumption of pork meat in a whole diet
on the fractional absorption of non-haem iron and the total absorption
of iron, when compared to a vegetarian diet. A randomised cross-over
design with 3x5 d whole-diet periods with diets containing
Danish-produced meat, Polish-produced meat or a vegetarian diet was
conducted. Nineteen healthy female subjects completed the study. All
main meals in the meat diets contained 60 g of pork meat and all diets
had high phytic acid content (1250 mumol/d). All main meals were
extrinsically labelled with the radioactive isotope (59)Fe and
absorption of iron was measured in a whole body counter. The non-haem
iron absorption from the Danish meat diet was significantly higher
compared to the vegetarian diet (P=0.031). The mean fractional
absorption of non-haem iron was 7.9 (se1.1), 6.8 (se 1.0) and 5.3 (se
0.6) % for the Danish and Polish meat diets and vegetarian diet,
respectively. Total absorption of iron was higher for both meat diets
compared to the vegetarian diet (Danish meat diet: P=0.006, Polish meat
diet: P=0.003). The absorption ratios of the present study were well in
accordance with absorption ratios estimated using algorithms on iron
bioavailability. Neither the meat diets nor the vegetarian diets
fulfilled the estimated daily requirements of absorbed iron in spite of
a meat intake of 180 g/d in the meat diets.

PMID: 16115336 [PubMed - in process]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

"Actually .. this article seems to say .. even a HIGH .. meat based ..
diet .. does not allow one access to enough iron to .. constitute ..
ENOUGH .. iron .. in the diet .. or what .. they .. have decided to BE
... sufficient .. iron .."

Nope, it is in fact a fatal contridiction to your notions, a little logic
saves alot of time. In science when a notion fails we turn from it in
pursuit of truth.

The article states a normal diet consisting of meat /and or vegetarian
diet .. did not meet the requirements of iron absorption .. seemingly
contrary to what previous studies .. have shown.

Quoted message said:

Quoted message said:

The absorption ratios of the present study were well in
accordance with absorption ratios estimated using algorithms on iron
bioavailability. Neither the meat diets nor the vegetarian diets
fulfilled the estimated daily requirements of absorbed iron in spite of

a meat intake of 180 g/d in the meat diets
<<

Quoted message said:

Quoted message said:

using algorithms on iron
bioavailability
<<

This means ESTABLISHED / accepted .. by all ..

Quoted message said:

Quoted message said:

Neither the meat diets nor the vegetarian diets
fulfilled the estimated daily requirements of absorbed iron
<<

CONTRARY to what the ... calculations .. say .. iron is NOT absorbed at
a high enough rate .. at THAT food intake ..

So .. like I said ..

This diet above .. commonly consumed by our .. peers .. does not give
one enough iron to .. survive ..

According to all those .. smart .. guys ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

*Total consumption per day, 6.4 oz.

http://www.superbad.com/1/meat/

The link above tells us to eat 5 - 7 ounces of meat perday ..

The study found 180 grams is not enough .. and THAT .. is .. precisely
... 7 ounces of meat .. give or take a few grams ..

So .. a .. RECOMMENDED .. amount of meat .. does NOT .. give one enough
.... iron ..

So .. as I said .. the diet being PRESENTLY consumed .. and which has
been consumed for .. forever .. is NOT .. enough to give enough iron ..
to .. survive ..

'They' .. screwed up .. again ..

I .. guess ..

Or are they .. SCREWING .. up .. again ..?

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

What jackass crossposted this?

<[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

*Total consumption per day, 6.4 oz.

http://www.superbad.com/1/meat/

The link above tells us to eat 5 - 7 ounces of meat perday ..

The study found 180 grams is not enough .. and THAT .. is .. precisely
.. 7 ounces of meat .. give or take a few grams ..

So .. a .. RECOMMENDED .. amount of meat .. does NOT .. give one enough
... iron ..

So .. as I said .. the diet being PRESENTLY consumed .. and which has
been consumed for .. forever .. is NOT .. enough to give enough iron ..
to .. survive ..

'They' .. screwed up .. again ..

I .. guess ..

Or are they .. SCREWING .. up .. again ..?

Who loves ya.
Tom

Good point Tom. Obviously from your conclusion we can also conclude that
eating 7oz of meat is safe, in your context. That, of accidental Iron
poisoning. Can we agree on that, or are you a moron?

To everyone else, cant you see how easy it is to destroy a delusional
psychotics delusions? Watch how he tries to skip and dance around the only
logical conclusion. That being his own study has shown 7oz of meat does NOT
provide enough iron to survive. So we should all strive to eat more than
7oz of meat a day. As Tom says we will not survive by eating less than 7oz
of meat. Do I have that right...? Yes, yes I think I do.

Next...

Rob

Rob

Quoted message said:

*Total consumption per day, 6.4 oz.

http://www.superbad.com/1/meat/

The link above tells us to eat 5 - 7 ounces of meat perday ..

The study found 180 grams is not enough .. and THAT .. is .. precisely
.. 7 ounces of meat .. give or take a few grams ..

So .. a .. RECOMMENDED .. amount of meat .. does NOT .. give one
enough ... iron ..

So .. as I said .. the diet being PRESENTLY consumed .. and which has
been consumed for .. forever .. is NOT .. enough to give enough iron
.. to .. survive ..

Neither does the recommended number of fruit servings give enough vitamin C.

Quoted message said:

'They' .. screwed up .. again ..

Not at all. You see... unlike you, they have enough brains to know that
practically no one eats nothing but meat.

Quoted message said:

I .. guess ..

Or are they .. SCREWING .. up .. again ..?

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

Quoted message said:

Quoted message said:

Good point Tom. Obviously from your conclusion we can also conclude
that
eating 7oz of meat is safe, in your context. That, of accidental Iron
poisoning. Can we agree on that, or are you a moron? <<

What .. you don't think researchers can be .. wrong .. ?

Quoted message said:

Quoted message said:

To everyone else, cant you see how easy it is to destroy a delusional
psychotics delusions? Watch how he tries to skip and dance around the
only
logical conclusion.
<<

Logical conclusion .. ?

How many approved .. drugs .. have NOW been taken off the market
BECAUSE .. they fkd .. up ..?

The study says .. the diet we have been consuming for a very long time
... is .. INSUFFICIENT .. to supply the RECOMMENDED doses of iron ..

Now if one ACCEPTS THE FKG RECOMMENDED DOES AS CORRECT .. then .. one
WOULD COME TO THE LOGICAL FKG CONCLUSION .. that you seem to have
accepted ..

But .. if one .. KNOWS these braindeadfkgmorons .. LIKE I DO .. then
maybe one wouldn't be so .. accepting ..

The study 'could' be .. accepted .. as .. THE MARKERS USED ARE SET TOO
FKG HIGH AND EVEN A WELL FED PERSON CANNOT GET ENOUGH IRON TO ..
fulfill .. THE RECOMMENDED DOSES OF FKG .. iron ..

But .. THAT .. would be .. impossible .. BECAUSE .. the researchers are
sooooooooooo fkg .. smart ..

Eh ..

I wonder if it is the same researchers who have had their drugs and
cash pulled out from under .. them ..?

Nah ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking