And what exactly are we to make of this, how does it relate to any body of
theory, to what practical use is it, and toward what goal can it be
applied? Without this information it is but another random abstract
plucked from the web, one among thousands of such.
Quoted message said:--------------------------------------------------------------------------
Curr Eye Res 1988 Jul;7(7):655-60
Liquefaction of rabbit vitreous by ferrous ions.
Hui YN, Sorgente N, Ryan SJ
Department of Ophthalmology, University of Southern California School
of Medicine, Los Angeles.Intravitreal injection of 0.7 mumol of ferrous chloride in 0.1 ml into
the rabbit eye resulted in liquefaction of the vitreous gel and
condensation of vitreous collagen fibrils within two weeks; injection
of 0.1 mumol did not cause any obvious vitreous degeneration, although
retina damage was noted in the posterior pole. Macrophages migrated at
the vitreoretinal interface and local posterior vitreous separation
was observed after the injection of ferrous solution. This suggests
that the least amount of ferrous ions necessary to cause liquefaction
of the rabbit vitreous is in the range of 16.8 to 39.2 micrograms of
elemental iron, a concentration of 0.3 to 0.7 mM in the vitreous.
Since 0.1 ml of blood contains approximately 50 micrograms of iron, it
is possible, at least theoretically, that the iron released by
hemoglobin following vitreous hemorrhage could induce liquefaction of
the vitreous.PMID: 3416619, UI: 88328444
___________________________________Indian J Ophthalmol. 2004 Jun;52(2):145-8. Related Articles, Links
Trace elements iron, copper and zinc in vitreous of patients with various
vitreoretinal diseases.Konerirajapuram NS, Coral K, Punitham R, Sharma T, Kasinathan N,
Sivaramakrishnan R.Biochemistry Research Department, Sankara Nethralaya, Chennai, India.
PURPOSE: To measure the concentrations of iron, copper and zinc in human
vitreous and to interpret their levels with various vitreoretinal diseases like
proliferative diabetic retinopathy, retinal detachment, intraocular foreign
body, Eales' disease and macular hole. METHODS: Undiluted vitreous fluid
collected during pars plana vitrectomy was used to measure trace elements using
an atomic absorption spectrophotometer. RESULTS: The level of vitreous iron
increased threefold in Eales' disease (1.85 +/- 0.36 pg/ml), 2.5-fold in
proliferative diabetic retinopathy (1.534 +/- 0.17 pg/ml) and 2.3-fold in eyes
with intraocular foreign body (1.341 +/- 0.25 pg/ml) when compared with macular
hole (0.588 +/- 0.16 pg/ml). This was statistically significant (P < 0.05).
Zinc was found to be low in Eales' disease (0.57 +/- 0.22 pg/ ml) when compared
with other groups, though the difference was not statistically significant.
CONCLUSION: The increased level of iron with decreased zinc content in Eales'
disease confirms the earlier reported oxidative stress mechanism for the
disease. In proliferative diabetic retinopathy and intraocular foreign body the
level of iron increases. This is undesirable as iron can augment glycoxidation,
which can lead to increased susceptibility to oxidative damage, in turn causing
vitreous liquefaction, posterior vitreous detachment and ultimately retinal
detachment and vision loss.PMID: 15283220 [PubMed - in process]
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