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Re: Ovarian cancer / meat consumption

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General fitness, health and nutrition
Published
7 September 2004
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16 September 2004
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[email hidden]@toad-net.com
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  1. So you advise eating animals low in saturated fats, that being the risk
    factor at issue here?

    Quoted message said:

    <<snip>>
    ovarian cancer risk was positively associated with higher consumption of
    dietary cholesterol
    <<snip>>

    Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1521-7. Related Articles,
    Links

    A case-control study of diet and the risk of ovarian cancer.

    Pan SY, Ugnat AM, Mao Y, Wen SW, Johnson KC, The Canadian Cancer Registries
    Epidemiology Research Group.

    Surveillance and Risk Assessment Division, Center for Chronic Disease
    Prevention and Control, Population and Public Health Branch, Health Canada, 120
    Colonnade Road, Locator 6702A, Ottawa, Ontario, Canada K1A 0K9.
    [email hidden]

    Epidemiologic studies have suggested that some dietary factors may play a role
    in the etiology of ovarian cancer, but the findings have been inconsistent. We
    assessed the association of ovarian cancer with dietary factors in a
    population-based case-control study in Canada. Diet information was collected
    on 442 incident cases of ovarian cancer diagnosed in 1994 to 1997 and 2,135
    population controls via a self-administered questionnaire. Compared with women
    in the lowest quartile of cholesterol intake, those in the second, third, and
    fourth quartiles had a multivariate adjusted odds ratio [OR; 95% confidence
    interval (95% CI)] of 1.12 (0.81-1.56), 1.20 (0.85-1.68), and 1.42 (1.03-1.97),
    respectively (P for trend = 0.031). Higher egg consumption was also associated
    with a nonsignificant increase in ovarian cancer risk. The ORs (95% CIs) for
    ovarian cancer were 0.77 (0.60-1.04) and 0.76 (0.56-0.99) among women in the
    highest quartile of total vegetable and cruciferous vegetable intake as
    compared with women in the lowest quartile. Women who took supplements of
    vitamin E, beta-carotene, and B-complex vitamins for >/=10 years had ORs (95%
    CIs) of 0.49 (0.30-0.81), 0.31 (0.11-0.91), and 0.61 (0.36-1.05), respectively.
    However, we did not observe an association of ovarian cancer risk with dietary
    fat intake, including saturated, monounsaturated, and polyunsaturated fatty
    acids, protein, carbohydrate, dietary fiber, fruit, dairy products, meat
    products, fish, chicken, grain products, nut products, baked desserts,
    margarine, butter, mayonnaise, and supplement of multiple vitamins, vitamin A,
    vitamin C, calcium, iron, zinc, and selenium. Our findings suggested that
    ovarian cancer risk was positively associated with higher consumption of
    dietary cholesterol and eggs and inversely associated with higher intake of
    total vegetables and cruciferous vegetables and supplementation of vitamin E,
    beta-carotene, and B-complex vitamins.

    PMID: 15342455 [PubMed - in process]

    --------------------------------------------------------------------------
    ------

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  2. Quoted message said:

    Subject: Re: Ovarian cancer / meat consumption
    From: [email hidden]@toad-net.com
    Date: 9/7/2004 12:03 PM Mountain Daylight Time
    Message-id: <[email hidden]>

    So you advise eating animals low in saturated fats, that being the risk
    factor at issue here?

    Like it says .. cholesterol ..
    Like the article is about .. cholesterol ..
    Does the article say it is ABOUT .. saturated fat .. or .. does it say it is
    about .. cholesterol .. ?

    Quoted message said:
    Quoted message said:

    <<snip>>
    ovarian cancer risk was positively associated with higher consumption of
    dietary cholesterol
    <<snip>>

    Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1521-7. Related Articles,
    Links

    A case-control study of diet and the risk of ovarian cancer.

    Pan SY, Ugnat AM, Mao Y, Wen SW, Johnson KC, The Canadian Cancer Registries
    Epidemiology Research Group.

    Surveillance and Risk Assessment Division, Center for Chronic Disease
    Prevention and Control, Population and Public Health Branch, Health Canada,


    120

    Quoted message said:

    Colonnade Road, Locator 6702A, Ottawa, Ontario, Canada K1A 0K9.
    [email hidden]

    Epidemiologic studies have suggested that some dietary factors may play a


    role

    Quoted message said:

    in the etiology of ovarian cancer, but the findings have been inconsistent.


    We

    Quoted message said:

    assessed the association of ovarian cancer with dietary factors in a
    population-based case-control study in Canada. Diet information was


    collected

    Quoted message said:

    on 442 incident cases of ovarian cancer diagnosed in 1994 to 1997 and 2,135
    population controls via a self-administered questionnaire. Compared with


    women

    Quoted message said:

    in the lowest quartile of cholesterol intake, those in the second, third,


    and

    Quoted message said:

    fourth quartiles had a multivariate adjusted odds ratio [OR; 95% confidence
    interval (95% CI)] of 1.12 (0.81-1.56), 1.20 (0.85-1.68), and 1.42


    (1.03-1.97),

    Quoted message said:

    respectively (P for trend = 0.031). Higher egg consumption was also


    associated

    Quoted message said:

    with a nonsignificant increase in ovarian cancer risk. The ORs (95% CIs) for
    ovarian cancer were 0.77 (0.60-1.04) and 0.76 (0.56-0.99) among women in the
    highest quartile of total vegetable and cruciferous vegetable intake as
    compared with women in the lowest quartile. Women who took supplements of
    vitamin E, beta-carotene, and B-complex vitamins for >/=10 years had ORs


    (95%

    Quoted message said:

    CIs) of 0.49 (0.30-0.81), 0.31 (0.11-0.91), and 0.61 (0.36-1.05),


    respectively.

    Quoted message said:

    However, we did not observe an association of ovarian cancer risk with


    dietary

    Quoted message said:

    fat intake, including saturated, monounsaturated, and polyunsaturated fatty
    acids, protein, carbohydrate, dietary fiber, fruit, dairy products, meat
    products, fish, chicken, grain products, nut products, baked desserts,
    margarine, butter, mayonnaise, and supplement of multiple vitamins, vitamin


    A,

    Quoted message said:

    vitamin C, calcium, iron, zinc, and selenium. Our findings suggested that
    ovarian cancer risk was positively associated with higher consumption of
    dietary cholesterol and eggs and inversely associated with higher intake of
    total vegetables and cruciferous vegetables and supplementation of vitamin


    E,

    Quoted message said:

    beta-carotene, and B-complex vitamins.

    PMID: 15342455 [PubMed - in process]

    --------------------------------------------------------------------------
    ------

    Who loves ya.
    Tom

    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  3. Ok, do you suggest eating meat with less cholesterol, as this is at issue
    in this information?

  4. [email hidden]@toad-net.com wrote in message news:<[email hidden]>...

    Quoted message said:

    So you advise eating animals low in saturated fats, that being the risk
    factor at issue here?

    Ummm, to quote the abstract: "However, we did not observe an
    association of ovarian cancer risk with dietary
    fat intake, including saturated, monounsaturated, and polyunsaturated
    fatty
    acids..."

    So no, saturated fats don't seem to matter. Just cholesterol.

    Quoted message said:
    Quoted message said:

    <<snip>>
    ovarian cancer risk was positively associated with higher consumption of
    dietary cholesterol
    <<snip>>

    Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1521-7. Related Articles,
    Links

    A case-control study of diet and the risk of ovarian cancer.

    Pan SY, Ugnat AM, Mao Y, Wen SW, Johnson KC, The Canadian Cancer Registries
    Epidemiology Research Group.

    Surveillance and Risk Assessment Division, Center for Chronic Disease
    Prevention and Control, Population and Public Health Branch, Health Canada, 120
    Colonnade Road, Locator 6702A, Ottawa, Ontario, Canada K1A 0K9.
    [email hidden]

    Epidemiologic studies have suggested that some dietary factors may play a role
    in the etiology of ovarian cancer, but the findings have been inconsistent. We
    assessed the association of ovarian cancer with dietary factors in a
    population-based case-control study in Canada. Diet information was collected
    on 442 incident cases of ovarian cancer diagnosed in 1994 to 1997 and 2,135
    population controls via a self-administered questionnaire. Compared with women
    in the lowest quartile of cholesterol intake, those in the second, third, and
    fourth quartiles had a multivariate adjusted odds ratio [OR; 95% confidence
    interval (95% CI)] of 1.12 (0.81-1.56), 1.20 (0.85-1.68), and 1.42 (1.03-1.97),
    respectively (P for trend = 0.031). Higher egg consumption was also associated
    with a nonsignificant increase in ovarian cancer risk. The ORs (95% CIs) for
    ovarian cancer were 0.77 (0.60-1.04) and 0.76 (0.56-0.99) among women in the
    highest quartile of total vegetable and cruciferous vegetable intake as
    compared with women in the lowest quartile. Women who took supplements of
    vitamin E, beta-carotene, and B-complex vitamins for >/=10 years had ORs (95%
    CIs) of 0.49 (0.30-0.81), 0.31 (0.11-0.91), and 0.61 (0.36-1.05), respectively.
    However, we did not observe an association of ovarian cancer risk with dietary
    fat intake, including saturated, monounsaturated, and polyunsaturated fatty
    acids, protein, carbohydrate, dietary fiber, fruit, dairy products, meat
    products, fish, chicken, grain products, nut products, baked desserts,
    margarine, butter, mayonnaise, and supplement of multiple vitamins, vitamin A,
    vitamin C, calcium, iron, zinc, and selenium. Our findings suggested that
    ovarian cancer risk was positively associated with higher consumption of
    dietary cholesterol and eggs and inversely associated with higher intake of
    total vegetables and cruciferous vegetables and supplementation of vitamin E,
    beta-carotene, and B-complex vitamins.

    PMID: 15342455 [PubMed - in process]

    --------------------------------------------------------------------------
    ------

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  5. [email hidden] (doe) wrote in message news:<[email hidden]>...

    Quoted message said:
    Quoted message said:

    Subject: Re: Ovarian cancer / meat consumption
    From: [email hidden]@toad-net.com
    Date: 9/7/2004 12:03 PM Mountain Daylight Time
    Message-id: <[email hidden]>

    So you advise eating animals low in saturated fats, that being the risk
    factor at issue here?

    Like it says .. cholesterol ..
    Like the article is about .. cholesterol ..
    Does the article say it is ABOUT .. saturated fat .. or .. does it say it is
    about .. cholesterol .. ?


    Hmm yes cholesterol is bad. So human breast milk which is loaded with
    cholesterol is bad for infants. Why did god put cholesterol in human
    breast milk. To poison babies?? Or maybe for some strange reason
    babies and growing children require cholesterol but all of the sudden
    for no reason when they are done breast feeding they need 0
    cholesterol and in fact it becomes poisonous and deadly? Only morons
    and ignorants like you could think that a vital nutrient is unhealthy.

  6. "Wolfbrother" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    [email hidden] (doe) wrote in message


    news:<[email hidden]>...

    Quoted message said:
    Quoted message said:
    Quoted message said:

    Subject: Re: Ovarian cancer / meat consumption
    From: [email hidden]@toad-net.com
    Date: 9/7/2004 12:03 PM Mountain Daylight Time
    Message-id: <[email hidden]>

    So you advise eating animals low in saturated fats, that being the risk
    factor at issue here?

    Like it says .. cholesterol ..
    Like the article is about .. cholesterol ..
    Does the article say it is ABOUT .. saturated fat .. or .. does it say


    it is

    Quoted message said:
    Quoted message said:

    about .. cholesterol .. ?


    Hmm yes cholesterol is bad. So human breast milk which is loaded with
    cholesterol is bad for infants. Why did god put cholesterol in human
    breast milk. To poison babies?? Or maybe for some strange reason
    babies and growing children require cholesterol but all of the sudden
    for no reason when they are done breast feeding they need 0
    cholesterol and in fact it becomes poisonous and deadly? Only morons
    and ignorants like you could think that a vital nutrient is unhealthy.

    If breast milk is a vital nutrient moron, then why do women stop producing
    milk after a few months? Why do people develop lactose intolerance? Could it
    be natures way to say that you should stop sucking cholesterol because you
    aren't a baby anymore? Not to a moron like you.
    Your logic still sucks.

  7. Quoted message said:

    Subject: Re: Ovarian cancer / meat consumption
    From: [email hidden] (Wolfbrother)
    Date: 9/8/2004 11:08 PM Mountain Daylight Time
    Message-id: <[email hidden]>

    [email hidden] (doe) wrote in message
    news:<[email hidden]>...

    Quoted message said:
    Quoted message said:

    Subject: Re: Ovarian cancer / meat consumption
    From: [email hidden]@toad-net.com
    Date: 9/7/2004 12:03 PM Mountain Daylight Time
    Message-id: <[email hidden]>

    So you advise eating animals low in saturated fats, that being the risk
    factor at issue here?

    Like it says .. cholesterol ..
    Like the article is about .. cholesterol ..
    Does the article say it is ABOUT .. saturated fat .. or .. does it say it


    is

    Quoted message said:

    about .. cholesterol .. ?


    Hmm yes cholesterol is bad. So human breast milk which is loaded with
    cholesterol is bad for infants. Why did god put cholesterol in human
    breast milk. To poison babies?? Or maybe for some strange reason
    babies and growing children require cholesterol but all of the sudden
    for no reason when they are done breast feeding they need 0
    cholesterol and in fact it becomes poisonous and deadly? Only morons
    and ignorants like you could think that a vital nutrient is unhealthy.

    Quoted message said:

    Hmm yes cholesterol is bad.

    Did I say .. that .. ?
    Did you hear me say .. that .. ?

    He asked what the article was about ..

    He was told it is about cholesterol ..

    You have a problem with that .. ?

    The .. key .. is ..

    If you have cholesterol .. you have .. blood .. very .. close .. by ..

    So .. one might say .. ANY .. 'study' .. which refers TO .. 'cholesterol
    consumption' .. would .. mean .. meat / association consumption ..

    Understand .. ?

    So .. it .. would .. mean .. increased .. iron .. availability AND absorption
    ...

    And since they have shown iron .. deprivation .. to be useful in cancer
    treatment .. and since iron is NOW being 'targeted' IN .. various .. cancers ..
    the association .. exists ..

    I take em where I can get em ..

    Chances .. are .. the study group was NOT .. 'lacto-ovo' .. to a large extent
    ...

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  8. On 8 Sep 2004 22:08:21 -0700, [email hidden] (Wolfbrother)

    Quoted message said:

    [email hidden] (doe) wrote in message news:<[email hidden]>...

    Quoted message said:
    Quoted message said:

    Subject: Re: Ovarian cancer / meat consumption
    From: [email hidden]@toad-net.com
    Date: 9/7/2004 12:03 PM Mountain Daylight Time
    Message-id: <[email hidden]>

    So you advise eating animals low in saturated fats, that being the risk
    factor at issue here?

    Like it says .. cholesterol ..
    Like the article is about .. cholesterol ..
    Does the article say it is ABOUT .. saturated fat .. or .. does it say it is
    about .. cholesterol .. ?


    Hmm yes cholesterol is bad. So human breast milk which is loaded with
    cholesterol is bad for infants. Why did god put cholesterol in human
    breast milk. To poison babies?? Or maybe for some strange reason
    babies and growing children require cholesterol but all of the sudden
    for no reason when they are done breast feeding they need 0
    cholesterol and in fact it becomes poisonous and deadly? Only morons
    and ignorants like you could think that a vital nutrient is unhealthy.

    What exactly makes it a vital nutrient? We know it clogs arteries but
    what other things does do?

  9. x-no-archive: yes

    Quoted message said:


    If breast milk is a vital nutrient moron, then why do women stop producing
    milk after a few months?

    HUH???

    We produce milk for as long as someone keeps drinking it.

    Susan

  10. x-no-archive: yes

    Both breast and ovarian cancers are associated with higher starch (or high GL)
    diet, not with fat consumption (accompanies cholesterol):

    Cancer Causes Control 2002 Apr;13(3):255-61 Related Articles, Links

    Nutrient intake and ovarian cancer: an Italian case-control study.

    Bidoli E, La Vecchi C, Montella M, Maso LD, Conti E, Negri E, Scarabelli C,
    Carbone A, Decarli A, Franceschi S.

    Epidemiology Unit, Centro di Riferimento Oncologico, Aviano, Italy.
    [email hidden]

    OBJECTIVE: The role of selected macronutrients, cholesterol, and fatty acids in
    the etiology of epithelial ovarian cancer was analyzed using data from a
    case-control study carried out in five Italian areas between January 1992 and
    December 1999. METHODS: Cases comprised 1,031 women with incident,
    histologically confirmed epithelial ovarian cancer, admitted to the major
    teaching and general hospitals of the study areas. Controls comprised 2,411
    women admitted for acute, non-neoplastic conditions to the same network of
    hospitals. Information on dietary habits was elicited using a validated
    food-frequency questionnaire including 78 food groups and recipes. Odds ratios
    (OR) and their corresponding 95% confidence intervals (CI) were computed by
    subsequent quintiles of nutrient intake. RESULTS: Direct associations with
    ovarian cancer emerged for starch intake (OR = 1.4 in the highest vs the lowest
    quintile of intake; 95% CI 1.1-1.8), while inverse associations emerged for
    monounsaturated (OR=0.7; 95% CI 0.5-0.9), and polyunsaturated (OR = 0.7; 95% CI
    0.5-0.9) fatty acids. Among fatty acids, oleic (OR = 0.7; 95% CI 0.5-0.9),
    linoleic (OR = 0.7; 95% CI 0.5-0.9), and linolenic (OR = 0.8; 95% CI 0.6-1.0)
    acids were inversely related to ovarian cancer. When, however, six
    macronutrients were included in the same model, only the adverse effect of high
    starch intake remained significant. Results were consistent in separate strata
    of menopausal status, parity, and energy intake. CONCLUSIONS: Starch was
    directly associated, and unsaturated fatty acids were inversely associated,
    with ovarian cancer risk.

    PMID: 12020107 [PubMed - indexed for MEDLINE]

    Ann Oncol 2003 Jan;14(1):78-84 Related Articles, Links

    Dietary glycemic index, glycemic load and ovarian cancer risk: a case-control
    study in Italy.

    Augustin LS, Polesel J, Bosetti C, Kendall CW, La Vecchia C, Parpinel M, Conti
    E, Montella M, Franceschi S, Jenkins DJ, Dal Maso L.

    Servizio di Epidemiologia, Centro di Riferimento Oncologico, Istituto Nazionale
    Tumori, Aviano, Italy.

    BACKGROUND: Dietary carbohydrates vary in their ability to raise blood glucose
    and insulin levels, which, in turn, influence levels of sex hormones and
    insulin-like growth factors. We analyzed the effect of type and amount of
    carbohydrates on ovarian cancer risk, using the glycemic index (GI) and the
    glycemic load (GL) measurement in a large case-control study conducted in
    Italy. MATERIALS AND METHODS: Cases included 1031 women with incident,
    histologically confirmed epithelial ovarian cancer, from four Italian regions.
    Controls included 2411 women admitted to the same hospital networks for acute,
    non-neoplastic conditions. Average daily GI and GL were calculated from a
    validated food frequency questionnaire. Odds ratios (OR) and the corresponding
    95% confidence intervals (CI) were computed using multiple logistic regression.
    RESULTS: Ovarian cancer was directly associated with dietary GI (OR for highest
    versus lowest quartile = 1.7, 95% CI 1.3-2.1) and GL (OR = 1.7, 95% CI
    1.3-2.1). The associations were observed in pre- and postmenopausal women, and
    they remained consistent across strata of major covariates identified.
    CONCLUSIONS: This study supports the hypothesis of a direct association between
    GI and GL and ovarian cancer risk and, consequently, of a possible role of
    hyperinsulinemia/insulin resistance in ovarian cancer development.

    PMID: 12488297 [PubMed - in process]

    The largest and most comprehensive study on diet and breast cancer to
    date, studying over 5,000 women between 1991 and 1994, showed that
    women with the lowest intake of dietary fat had a significantly higher
    incidence of breast cancer than the women with the highest intake of
    dietary fat. It also found that women with the highest intake of
    starch had a significantly higher incidence of breast cancer than the
    women with the lowest intake of starch. The study found no evidence
    that saturated fat had any effect one way or the other on breast
    cancer, and that unsaturated fat had a significantly protective effect
    against breast cancer. (Franceschi S et. al. Intake of macronutrients
    and risk of breast cancer. Lancet; 347(9012):1351-6 1996)

    Susan

  11. Quoted message said:

    Subject: Re: Ovarian cancer / meat consumption
    From: [email hidden] (Susan )

    CONCLUSIONS: This study supports the hypothesis of a direct association between
    GI and GL and ovarian cancer risk and, consequently, of a possible role of
    hyperinsulinemia/insulin resistance in ovarian cancer development.

    PMID: 12488297 [PubMed - in process]

    This .. could .. mean .. ABILITY .. to .. 'assimilate' .. carbohydrates ..
    properly ..is impaired ..

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  12. "Robert" <[email hidden]> wrote in message news:<[email hidden]>...

    Quoted message said:

    "Wolfbrother" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    [email hidden] (doe) wrote in message


    news:<[email hidden]>...

    Quoted message said:
    Quoted message said:

    >Subject: Re: Ovarian cancer / meat consumption
    >From: [email hidden]@toad-net.com
    >Date: 9/7/2004 12:03 PM Mountain Daylight Time
    >Message-id: <[email hidden]>
    >
    >
    >So you advise eating animals low in saturated fats, that being the risk
    >factor at issue here?

    Like it says .. cholesterol ..
    Like the article is about .. cholesterol ..
    Does the article say it is ABOUT .. saturated fat .. or .. does it say


    it is

    Quoted message said:
    Quoted message said:

    about .. cholesterol .. ?


    Hmm yes cholesterol is bad. So human breast milk which is loaded with
    cholesterol is bad for infants. Why did god put cholesterol in human
    breast milk. To poison babies?? Or maybe for some strange reason
    babies and growing children require cholesterol but all of the sudden
    for no reason when they are done breast feeding they need 0
    cholesterol and in fact it becomes poisonous and deadly? Only morons
    and ignorants like you could think that a vital nutrient is unhealthy.

    If breast milk is a vital nutrient moron, then why do women stop producing
    milk after a few months? Why do people develop lactose intolerance? Could it
    be natures way to say that you should stop sucking cholesterol because you
    aren't a baby anymore? Not to a moron like you.
    Your logic still sucks.

    Righty because babies stop growing and devoloping after 1 or 2 years
    of age. You are such a dumb ass.

  13. Quoted message said:

    What exactly makes it a vital nutrient? We know it clogs arteries but
    what other things does do?

    It is vital to the nervous system where it is part
    of the myelin sheath which is composed of 4 part
    cholesterol, 3 parts phosphoglycerides, and 2 parts
    galactolipids in the adult human myelin sheath.
    It is the source of bile and all steroid hormones.
    It is part of the cell membrane where it affect
    membrane fluidity.

    It is a vital nutrient to the cells and tissues though it
    synthesized by the organism. If the organism
    gets too much from both diet or internal synthesis to match
    it set point, it internal synthesis will be decreased.
    Or stated differently, the quantities synthesized vary inversely
    with dietary intake.

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