In article <[email hidden]>,
(Jan) said:Quoted message said:From: Orac [email hidden]
Date: 7/29/2003 7:12 AM Pacific Standard Time
Message-id: <[email hidden]>
<snip>
Quoted message said:Apples and oranges.
And placebo.
No, it's still apples and oranges.The cardiac problems from excessive
iron due to thalassemia major are a different disease process from
atherosclerotic heart disease, which is what alties advocate chelation
therapy for. To repeat: It is a DIFFERENT disease.
Quoted message said:ZZZZZZZZZZZZZZZZZZZZZZZzzzzzzzzzzzzzzzzzzzzZZZZZZZZZZZZZZZZZZZZZZZZZZZzzzz
zzzzzzzzzzzzzzzzzzz.
Quoted message said:It is merely evidence that
chelation therapy is effective as a treatment for excessive iron levels.
Reversal of cardiac complications in thalassemia major by long-term
intermittent daily intensive iron chelation.
The cardiac problems from excessive iron due to thalassemia major are
completely unrelated to atherosclerotic heart disease, which is what
alties advocate chelation therapy for. Once again, they represent a
different disease process that is related to excessive iron.
Atherosclerosis is not related to excessive iron from blood transfusions
and is not helped by chelation therapy.
Quoted message said:Miskin H, Yaniv I, Berant M, Hershko C, Tamary H.
Department of Pediatric Hematology/Oncology, Schneider Children's Medical
Center of Israel, Petah Tiqva, Israel.
OBJECTIVES: In patients with thalassemia major (TM) who are non-compliant with
long-term deferoxamine (DFO) chelation, survival is limited mainly because of
***cardiac complications***
The cardiac complications from excessive iron due to thalassemia major
are completely unrelated to atherosclerotic heart disease, which is what
alties advocate chelation therapy for. Once again, they represent a
different disease process that is related to excessive iron.
Atherosclerosis is not related to excessive iron from blood transfusions
and is not helped by chelation therapy.
Quoted message said:of transfusional siderosis. It was recently shown in a
small group of TM patients with established
***cardiac damage***
The cardiac damage from excessive iron due to thalassemia major is
completely unrelated to atherosclerotic heart disease, which is what
alties advocate chelation therapy for. Once again, they represent a
different disease process that is related to excessive iron.
Atherosclerosis is not related to excessive iron from blood transfusions
and is not helped by chelation therapy.
Quoted message said:that continuous 24-h
DFO infusion via an indwelling intravenous (i.v.) catheter is effective in
reversing cardiac toxicity. The aim of the present study was to evaluate the
results with intermittent daily (8-10 h) i.v. DFO. PATIENTS: Eight TM patients
with
***cardiac complications***
The cardiac complications from excessive iron due to thalassemia major
are completely unrelated to atherosclerotic heart disease, which is what
alties advocate chelation therapy for. Once again, they represent a
different disease process that is related to excessive iron.
Atherosclerosis is not related to excessive iron from blood transfusions
and is not helped by chelation therapy.
Quoted message said:treated with intensive intermittent DFO were
retrospectively evaluated by the mean annual serum ferritin, radionucleated
ventriculography and 24-h electrocardiography recordings. RESULTS: The median
age at diagnosis of
***cardiac disease***
The cardiac disease caused by excessive iron due to thalassemia major is
completely unrelated to atherosclerotic heart disease, which is what
alties advocate chelation therapy for. Once again, they represent a
different disease process that is related to excessive iron.
Atherosclerosis is not related to excessive iron from blood transfusions
and is not helped by chelation therapy.
Quoted message said:was 17.5 yr (range 14-21), and the median
follow-up time was 84 months (range, 36-120). In the majority of patients
(seven of eight) high-dose DFO (mean 95 +/- 18.3 mg/kg/d) was administered via
a central venous line. During follow-up, there was a significant decrease in
the mean ferritin levels (5828 +/- 2016 ng/mL to 1585 +/- 1849 ng/mL, P <
0.001). Both cardiac failure (mean ejection fraction 32 +/- 5) and
***cardiac arrhythmias were resolved in four of five patients***
The cardiac arrhythmias from excessive iron due to thalassemia major are
completely unrelated to atherosclerotic heart disease, which is what
alties advocate chelation therapy for. Once again, they represent a
different disease process that is related to excessive iron.
Atherosclerosis is not related to excessive iron from blood transfusions
and is not helped by chelation therapy.
Quoted message said:. One non-compliant patient
died during the follow-up. Following discontinuation of the i.v. therapy,
compliance with conventional DFO therapy improved. The complications of this
regimen, mainly catheter-related infections and catheter-related thrombosis,
were similar to those described earlier.
CONCLUSIONS: These results with the
longest follow-up period in the literature suggest that i.v. high-dose DFO for
8-10 h daily may be as effective as continuous 24-h infusion for the
*** reversal of established cardiac disease in TM.****
The established cardiac disease from excessive iron due to thalassemia
major is completely unrelated to atherosclerotic heart disease, which is
what alties advocate chelation therapy for. Once again, they represent a
different disease process that is related to excessive iron.
Atherosclerosis is not related to excessive iron from blood transfusions
and is not helped by chelation therapy.
Quoted message said:PMID: 12756023 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------
------
Who loves ya.
Tom
Quoted message said:Try again.
Read it until it soaks in.
No, YOU read it until it soaks in.
One more time: The cardiac damage from excessive iron loads is a
completely different disease process from atherosclerotic heart disease.
Excessive iron loads can be directly toxic to the heart. Chelation
therapy can be used to reduce iron loads in such iron excess conditions.
Chelation therapy does NOT however, reverse atherosclerotic heart
disease, nor does it reverse the damage to the heart caused by
atherosclerosis. Citing this study does NOT show that chelation therapy
is any good whatsoever for atherosclerotic heart disease, because it
does NOT even address atherosclerotic heart disease.
--
Orac |"A statement of fact cannot be insolent."
|
|"If you cannot listen to the answers, why do you
| inconvenience me with questions?"