Re: LDL Levels ?

John Sankey wrote:
::: Just one 200g can of clams a month gives you 3x the RDA of B12!

:: Do you imply that using B12 once a month is sufficient?

: The experts say yes, that our liver stores 6 months to 2 years
: worth of B12. However, I open a can of clams, drain it, stick
: most of it in the freezer to freeze loose, and eat 1 or 2 most
: days.

I have seen reports of an ongoing study by the University of Tuft which
shows that *40* percent of US population have either deficiency or
suboptimal B12 levels. B12 may contribute to cognitive decline and dementia.

As B12 is considered to be very safe supplement, I think that it is
reasonable to take higher doses of B12. Taking 1 mg twice a week is a widely
given recommendation by many experts. Larger doses are needed if the
secretion of intrinsic factor is impaired.

--
Juhana

Juhana Harju wrote:
: John Sankey wrote:
:::: Just one 200g can of clams a month gives you 3x the RDA of B12!
:
::: Do you imply that using B12 once a month is sufficient?
:
:: The experts say yes, that our liver stores 6 months to 2 years
:: worth of B12. However, I open a can of clams, drain it, stick
:: most of it in the freezer to freeze loose, and eat 1 or 2 most
:: days.
:
: I have seen reports of an ongoing study by the University of Tuft
: which shows that *40* percent of US population have either deficiency
: or suboptimal B12 levels. B12 may contribute to cognitive decline and
: dementia.

A reference:

http://www.findarticles.com/p/articles/mi_m3741/is_8_48/ai_64781713

: As B12 is considered to be very safe supplement, I think that it is
: reasonable to take higher doses of B12. Taking 1 mg twice a week is a
: widely given recommendation by many experts. Larger doses are needed
: if the secretion of intrinsic factor is impaired.

--
Juhana

Juhana Harju wrote:
: Juhana Harju wrote:

:: I have seen reports of an ongoing study by the University of Tuft
:: which shows that *40* percent of US population have either deficiency
:: or suboptimal B12 levels. B12 may contribute to cognitive decline and
:: dementia.
:
: A reference:
:
: http://www.findarticles.com/p/articles/mi_m3741/is_8_48/ai_64781713

The data can be found from this study related to B12 status and
osteoporosis:

http://www.jbmr-online.com/fulltext/02001/01520/JBMR0200101520.html

Click _Table 2_.

:: As B12 is considered to be very safe supplement, I think that it is
:: reasonable to take higher doses of B12. Taking 1 mg twice a week is a
:: widely given recommendation by many experts. Larger doses are needed
:: if the secretion of intrinsic factor is impaired.

--
Juhana

"Juhana Harju" <[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

Juhana Harju wrote:
: Juhana Harju wrote:

:: I have seen reports of an ongoing study by the University of Tuft
:: which shows that *40* percent of US population have either deficiency
:: or suboptimal B12 levels. B12 may contribute to cognitive decline and
:: dementia.
:
: A reference:

The link mentions 40% of atrophic gastritis rendering absorption of B12 more
problematic.

It is also mentions

"There is currently no clearly accepted cut-off for vitamin B12 deficiency.
A commonly used clinical cut-off for vitamin B12 deficiency is 148 pM (250
pg/ml).((14)) However, there is evidence that the sensitivity of this
clinical cut-off is poor and that many individuals with concentrations
previously labeled as "low normal" do have clinical symptoms.((15,16)) We
therefore also created a group between 148 and 185 pM (250 pg/ml) as a group
at high risk of vitamin B12 deficiency, a group between 185 and 258 pM (350
pg/ml) as a group at moderate risk of deficiency, and >258 pM, a cut-off
generally considered to be indicative of vitamin B12 adequacy.((15))"

I always consider it bad form to start changing definitions of what
constitutes vit B12 deficiency in a study.

Suffice it to say that the relationship between B12 levels is there.
Serum or blood B12 levels are not always accurate in determining B12
deficiency. The blood levels may be normal and still have CNS deficiency
with neurological problems. The various body compartments utilizes the
vitamin at differing rates and one site may not be reflective of the other.

Quoted message said:

:
: http://www.findarticles.com/p/articles/mi_m3741/is_8_48/ai_64781713

The data can be found from this study related to B12 status and
osteoporosis:

http://www.jbmr-online.com/fulltext/02001/01520/JBMR0200101520.html

Click _Table 2_.

:: As B12 is considered to be very safe supplement, I think that it is
:: reasonable to take higher doses of B12. Taking 1 mg twice a week is a
:: widely given recommendation by many experts. Larger doses are needed
:: if the secretion of intrinsic factor is impaired.

--
Juhana

"Juhana Harju" <[email hidden]> wrote in message
news:[email hidden]

Quoted message said:

:: I have seen reports of an ongoing study by the University of Tuft
:: which shows that *40* percent of US population have either deficiency
:: or suboptimal B12 levels. B12 may contribute to cognitive decline and
:: dementia.

40% of meat consuming population is just inbelievable .
Kam

Quoted message said:

: http://www.findarticles.com/p/articles/mi_m3741/is_8_48/ai_64781713

Quoted message said:

http://www.jbmr-online.com/fulltext/02001/01520/JBMR0200101520.html

Click _Table 2_.

:: As B12 is considered to be very safe supplement, I think that it is
:: reasonable to take higher doses of B12. Taking 1 mg twice a week is a
:: widely given recommendation by many experts. Larger doses are needed
:: if the secretion of intrinsic factor is impaired.

--
Posted via Mailgate.ORG Server - http://www.Mailgate.ORG

Kamalakar Pasupuleti wrote:
: "Juhana Harju" <[email hidden]> wrote in message
: news:[email hidden]
:
:::: *40* percent of US population have either
:::: deficiency or suboptimal B12 levels. B12 may contribute to
:::: cognitive decline and dementia.
:
: 40% of meat consuming population is just inbelievable .
: Kam

B12 in meat is bound to protein and is not so well absorbed.

--
Juhana

Robert wrote:
: "Juhana Harju" <[email hidden]> wrote in message
: news:[email hidden]...
:: Juhana Harju wrote:
::: Juhana Harju wrote:
::
:::: *40* percent of US population have either
:::: deficiency or suboptimal B12 levels. B12 may contribute to
:::: cognitive decline and dementia.
:::
::: A reference:
:
: The link mentions 40% of atrophic gastritis rendering absorption of
: B12 more problematic.

I have read that /Helicobacter pylori/ infection is one common factor
leading to atrophic gastritis, which in turn leads to lack of secretion of
intrinsic factor needed in B12 absorption. (I am not a physician.)

: It is also mentions
:
: "There is currently no clearly accepted cut-off for vitamin B12
: deficiency. A commonly used clinical cut-off for vitamin B12
: deficiency is 148 pM (250 pg/ml).((14)) However, there is evidence
: that the sensitivity of this clinical cut-off is poor and that many
: individuals with concentrations previously labeled as "low normal" do
: have clinical symptoms.((15,16)) We therefore also created a group
: between 148 and 185 pM (250 pg/ml) as a group at high risk of vitamin
: B12 deficiency, a group between 185 and 258 pM (350 pg/ml) as a group
: at moderate risk of deficiency, and >258 pM, a cut-off generally
: considered to be indicative of vitamin B12 adequacy.((15))"
:
: I always consider it bad form to start changing definitions of what
: constitutes vit B12 deficiency in a study.

Still it seems to me that it is reasonable to aim to have higher than
low-normal levels of B12.

: Suffice it to say that the relationship between B12 levels is there.
: Serum or blood B12 levels are not always accurate in determining B12
: deficiency. The blood levels may be normal and still have CNS
: deficiency with neurological problems. The various body compartments
: utilizes the vitamin at differing rates and one site may not be
: reflective of the other.

That is what I have heard too.

::: http://www.findarticles.com/p/articles/mi_m3741/is_8_48/ai_64781713
::
:: The data can be found from this study related to B12 status and
:: osteoporosis:
::
:: http://www.jbmr-online.com/fulltext/02001/01520/JBMR0200101520.html
::
:: Click _Table 2_.
::
::
:::: As B12 is considered to be very safe supplement, I think that it is
:::: reasonable to take higher doses of B12. Taking 1 mg twice a week
:::: is a widely given recommendation by many experts. Larger doses are
:::: needed if the secretion of intrinsic factor is impaired.

--
Juhana