Quoted message said:Quoted message said:On Apr 14, 4:20 pm, [email hidden] wrote:
No, iron levels were caused by cell damage releasing iron stored in
the
cell. Added to this was a lowered iron clerance level because of the
cell damage in the liver which normally clears the iron. Thus
increased
iron levels were these two factors in sum. The inflammation was not
the
cause of the increased levels.
The cell damage as source of iron increases has been brought to your
attention before, now your own abstract confirms it. Just to say
there
is a correlation with iron level and some disorder says nothing about
what causes what, the dog and tail story.<<
The .. HEMOLYSIS .. of the RED BLOOD CELLS .. causes **hyper**-
ferritinemia .. as evidenced below .. the ferritin is CREATED ..
when .. the iron and heme are present .. **TOGETHER** .. and
'coincidentally' .. red blood cells are made UP .. of .. ? .. heme and
iron ..
Hemolysis .. hemo-lysis / destroyed red blood cell yields / creates
heme and iron which then creates **ferritin** TO .. ? ..
**store** .. ? .. store .. ? .. iron .. ?
That .. is .. 'what' .. ferritin .. DOES ..
Didn't you know .. that .. ?
Did you think hyperferritinemia / it .. was caused by .. ? ..
hmmm .... inflammation .. ?
I .. think .. you .. do ..
So .. the hyperferritinemia found in .. people .. is the result of
increased iron either through ingestion OF iron .. or .. hemolysis of
red blood cells.
Heme controls antioxidants and iron in ferritin
October 11, 2005 - Discovery could improve or create treatments for
several chronic illnesses
Oakland, CA- A new study conducted by scientists at Children's
Hospital Oakland Research Institute could help researchers develop new
treatments for a variety of health conditions that are all related to
abnormal iron metabolism. More than one million Americans have
abnormal iron levels in their bodies. For example, iron excess can
lead to a long list of health problems including diabetes, heart
failure, liver cancer, arthritis and severe fatigue.
Ferritin is a protein that stores or releases iron in the body as it
is needed. Until now, scientists were convinced that the only way to
develop new therapies for treating iron overload was to focus on iron
metabolism. But a new study published in the October 10th issue of the
Proceedings of the National Academy of Sciences is the first to
demonstrate that the ferritin gene can be controlled by heme, and
other common antioxidant regulators. Heme is the molecule that
activates many protective genes and is also the part of the blood that
uses iron to carry oxygen from our lungs to the rest of the body.
Previously, scientists only focused on genes that were regulated by
iron for iron related diseases. Now it is clear that heme might be a
"master switch" for iron genes, and antioxidant genes, which are the
genes that protect and repair damage caused by oxygen radicals. If
that mechanism is found, heme could help scientists unravel the cause
and cures of several chronic illnesses.
"This new information will dramatically change the way researchers
think about solving certain health problems involving iron or
inflammation," said Elizabeth Theil, Ph.D., Senior Scientist at
Children's Hospital Oakland Research Institute and co-author of the
study. "For the first time we understand that ferritin is one of the
protective genes the body uses to protect us from the damage caused by
oxygen radicals. "
To find out what controlled ferritin genes; scientists studied
cultures of liver cells. They found that iron, by itself, was a weak
signal by linking different pieces of ferritin DNA to a "reporter"
gene and measuring the amount of reporter protein when cells were fed
extra iron, heme, or sulforphane. Iron had practically no effect, but
with heme or sulforphane much "reporter" was produced.
Scientists discovered that ferritin is a gene with two kinds of
genetic controllers: DNA plus mRNA. Iron regulates the mRNA. When the
two regulators were combined in the experiment, heme made the cells
produce huge amounts of reporter protein-three times more than either
one alone. Both DNA and mRNA carry genetic information. DNA is the
blueprint, protected in the nucleus, and mRNA is the working copies
used to manage day-to-day information and cell work.
"Our research shows that ferritin mRNA is sensitive to iron, ferritin
DNA is sensitive to antioxidants like sulforphane and heme coordinates
both DNA and mRNA," said Korry Hintze, a postdoctoral fellow at
Children's Hospital Oakland Research Institute and co-author of the
study. "Now we know that ferritin is central to both iron and oxygen
metabolism."
Children's Hospital & Research Center at Oakland
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Tom
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