"Alex" <[email hidden]> wrote in message
"]news:[email hidden]...
Quoted message said:Is there any product that can clear clogged arteries, that
has not got anything to do with surgery, springs, etc?
Any nutritional supplement, medication, etc. that can
do that?
It's most likely some kind of quackery, but I just want to
ask - is there anything in this "angioprim" product?
anginacure.comheartcleaning.htmOpen ↗
(I'm not promoting anything, but I'm just at least
intellectually exploring all possibilities.)
Alex
Alex:
Nutritional supplement -- no. but there is a product in
clinical trials managed by Cleveland Clinic that will do
just what you ask and many are pretty excited about it.
see: forrelease.comcltu044.P1.1104200Open ↗
3132644.25792.html
Study Shows Infusions of Synthetic HDL 'Good Cholesterol'
Can Remove Plaque From Coronary Arteries
Results of Cleveland Clinic-Directed Study to Appear
Nov. 5 in JAMA
CLEVELAND, Nov. 4 /PRNewswire/ -- Do 40 people in a
small village in rural Italy hold the key to reversing
plaque buildup in coronary arteries? A new study
appearing in the Nov. 5 edition of the Journal of the
American Medical Association provides strong evidence
that five weekly infusions of a synthetic form of "good
cholesterol," or HDL, can remove significant amounts of
plaque from these arteries.
"This is an extraordinary and unprecedented finding," said
Cleveland Clinic cardiologist Steven E. Nissen, M.D., who
directed the 10-center nationwide study. "This is the first
convincing demonstration that targeting HDL, good
cholesterol, can benefit patients with heart disease, the
leading cause of death in the United States."
The development of this investigational drug is an unusual
story. About 30 years ago, researchers discovered 40
individuals in Limone Sul Garda in Northern Italy who
appeared perfectly healthy, despite having very low levels
of good cholesterol. Ordinarily, such people would have a
high risk of heart disease, but these people did not.
Intrigued, researchers wanted to find out why. Their studies
revealed a variant in a protein known as Apolipoprotein A-
I, which is a component of HDL. This variant was named ApoA-
I Milano after the city of Milan, where the initial
laboratory work was done.
ApoA-I Milano is being developed into a potential treatment
for heart disease by Esperion Therapeutics Inc., an Ann
Arbor, Mich.-based biopharmaceutical company. Esperion's
investigational treatment, designated ETC-216, is a
recombinant version of ApoA-I Milano combined with a
phospholipid. After pre-clinical studies showed rapid
removal of plaques from diseased arteries, scientists at
Esperion came to Dr. Nissen to help them design a study to
determine whether infusions of the ApoA-I
Milano/phospholipid complex could reverse coronary plaque
buildup in patients with heart disease.
The Cleveland Clinic-directed study administered the ApoA-I
Milano/phospholipid complex intravenously over a five-week
period to a randomized group of patients initially
hospitalized for acute chest pain. Researchers measured
arterial plaques using intravascular ultrasound (IVUS)
before and after the six-week study. Patients who were given
the synthetic protein showed a dramatic decrease in arterial
plaques, whereas a comparison group given saline showed no
change in plaques.
Atherosclerosis, sometimes known as "hardening of the
arteries," is the process by which fatty deposits build up
on the inner lining of artery walls, creating plaques. These
plaques can grow large enough to significantly reduce blood
flow. If the plaques rupture, they can cut off blood flow to
vital organs, including the heart, causing heart attacks.
Traditional therapies for atherosclerosis focus on lowering
levels of "bad" cholesterol, known as LDL. Although high
levels of HDL have been shown to be beneficial, the clinical
significance of targeting HDL therapeutically was unknown.
This trial sought to test that possibility.
Dr. Nissen cautions that, "Much more testing needs to be
performed to determine whether this unique form of
HDL can be used routinely to treat patients with
atherosclerosis." He emphasized that the current
clinical trial was a small "proof of concept" study,
designed only to demonstrate the potential of this
new therapy.
"People should not view new therapies as a 'magic-bullet'
cure. For most of us, medicines will never replace the need
to make healthy lifestyle choices," Nissen said.
"Nonetheless, this study represents a paradigm shift," he
continued, "offering new hope for a devastating and common
disease. We now know that it is possible to actively remove
cholesterol plaques from the coronary arteries with drugs. I
am confident that eventually this approach will make a
significant difference in the care of patients with coronary
heart disease."
Study Details
The ApoA-I Milano trial involved 57 acute coronary
syndrome patients in a randomized, prospective, double-
blind, multicenter clinical trial conducted from November
2001 to March 2003. All patients had experienced an acute
coronary syndrome, either unstable angina (severe chest
pain) or heart attack. Each patient had a single coronary
artery examined using IVUS within two weeks following the
cardiac event.
IVUS technology gives doctors the ability to visualize
coronary plaques using high-frequency sound waves. The
procedure is performed along with cardiac catheterization.
Doctors are able to see detailed images of the interior
walls of the arteries and precisely measure the size of the
plaques inside the artery.
Patients were randomized to three treatment groups --
placebo, low dose or high dose of intravenous recombinant
ApoA-I Milano/phospholipid complex. The study drug was
administered as a weekly intravenous infusion for a total of
five weeks. Patients underwent IVUS of the originally imaged
coronary artery for a second time within two weeks following
the final infusion. The second images then were compared
with baseline images to compare plaque levels. Researchers
found a statistically significant change in volume of the
thickened, fatty lining inside the arteries of patients who
had received either the high or the low dose of intravenous
recombinant ApoA-I Milano/phospholipid complex.
The trial was conducted in 10 community and tertiary care
hospitals throughout the United States. Researchers at The
Cleveland Clinic reviewed all IVUS examinations without
knowing which patients had received which type of infusion.
Esperion Therapeutics funded this study.
The Cleveland Clinic Foundation, located in Cleveland, Ohio,
is a not-for- profit multispecialty academic medical center
that integrates clinical and hospital care with research and
education. The Cleveland Clinic was founded in 1921 by four
renowned physicians with a vision of providing outstanding
patient care based upon the principles of cooperation,
compassion and innovation. U.S. News & World Report
consistently names The Cleveland Clinic as one of the
nation's best hospitals in its annual "America's Best
Hospitals" survey. In 2003, The Cleveland Clinic is ranked
fifth overall. Approximately 1,200 full-time salaried
physicians at The Cleveland Clinic and Cleveland Clinic
Florida represent more than 100 medical specialties and
subspecialties. In 2002, there were nearly 2.5 million
outpatient visits to The Cleveland Clinic and more than
52,000 hospital admissions. Patients came for treatment from
every state and from more than 90 countries. The Cleveland
Clinic website address is clevelandclinic.orgclevelandclinic.orgOpen ↗ .
CONTACT: Alicia Sokol, +1-216-445-9661, or Eileen
Caruso Sheil,
+1-216-444-8927, both of The Cleveland Clinic Foundation
Web site: clevelandclinic.orgclevelandclinic.orgOpen ↗