Since the PROBLEM with the anti-psychotics IS the .. buildup of iron ..
then one might think the 'novel brain-targeted antioxidant ' .. might
be an iron .. chelator.
Clin Neuropharmacol. 2005 Nov-Dec;28(6):285-8. Related Articles, Links
A novel brain-targeted antioxidant (AD4) attenuates haloperidol-induced
abnormal movement in rats: implications for tardive dyskinesia.
Sadan O, Bahat-Stromza M, Gilgun-Sherki Y, Atlas D, Melamed E, Offen D.
Department of Neurology and Felsenstein Medical Research Center, Rabin
Medical Center, Petah Tikva, 49100 Israel.
BACKGROUND: Tardive dyskinesia (TD), characterized by abnormal
movements, is the major late-onset chronic side effect of antipsychotic
treatment found in about 30% of those patients. The association of
oxidative stress and the release of free radicals is one of the
hallmarks of dopaminergic malfunctions and is one of the leading
theories suggested for the pathophysiology of TD. To this day, no
brain-targeted antioxidant has been tested as a potential treatment of
TD. In light of this assumption, the authors chose a novel,
low-molecular weight thiol antioxidant, N-acetyl cysteine amide (AD4),
that crosses the blood-brain barrier as a possible treatment of TD.
OBJECTIVE: To examine the protective effects of the novel
brain-penetrating antioxidant AD4 on TD experimental models. METHODS:
The typical vacuous chewing movement occurs in rats following chronic
haloperidol injections (1.5 mg/kg/day intraperitoneally for 21 days).
This purposeless mouth opening in the vertical plane is similar to TD
symptoms in humans. The authors tested rats treated with haloperidol
without or with AD4 in the drinking water (1 g/kg orally).
Thiobarbituric acid reactive substances and anticarbonyl antibodies
were used to measure oxidation of membranes and proteins. RESULTS:
Haloperidol increased the vacuous chewing movements to 66.5 +/- 7.6
movements/5 minutes compared with 16.4 +/- 2.4 movements/5 minutes in
untreated rats (P < 0.01). Coadministration of haloperidol and AD4
decreased the vacuous chewing movements level to 42.1 +/- 6.7
movements/5 minutes (P < 0.05). Haloperidol also increased the level of
lipid peroxidation and protein oxidation in the rat brain, whereas
coadministration with AD4 preserved their normal levels. CONCLUSION:
Haloperidol causes behavioral abnormalities associated with oxidative
stress in rats, similar to TD. AD4, the brain-targeted potent
antioxidant, reduces the cellular oxidation markers and improves the
typical clinical behavior. Hence, AD4 is a potential new treatment of
antipsychotic-induced TD.
PMID: 16340385 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking