N-acetylcysteine / colitis

IT'S BEEN A PART OF MY NUTRIONAL REGIMEN FOR YEARS.
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J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related Articles, Links

Effects of N-acetylcysteine treatment on oxidative stress in acetic
acid-induced experimental colitis in rats.

Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M, Aydin HH.

Department of General Surgery, Ege University School of Medicine,
Bornova, Izmir, Turkey. [email hidden]

We assessed the possible protective effects of N-acetylcysteine (NAC)
against toxic damage in the rat colon. Two doses of NAC (20 mg/kg and
100 mg/kg) given for 2 days and 7 days after acetic acid administration
(to induce colitis) were tested. NAC was dissolved in saline and
administered locally (intracolonic), systemically (intraperitoneal) or
in a combination (intracolonic and intraperitoneal). Several
parameters, including macroscopic and histopathological scores and
myeloperoxidase, glutathione and nitric oxide concentrations were
measured using standard assay procedures. Treatment with 100 mg/kg NAC
for 7 days significantly decreased tissue myeloperoxidase, glutathione
and nitric oxide concentrations. The 20 mg/kg dose had no protective
effects. The data indicate that NAC substantially reduced the degree of
colonic injury, probably by regulating free radical production and
inhibiting inflammation. It may, therefore, have a role in the
treatment of inflammatory bowel disease.

PMID: 15790131 [PubMed - in process]

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Who loves ya.
Tom

Jesus Was A Vegetarian!
http://herbivore.7h.com

This is the first time I have heard of it, but I notice a lot of supplement
makers sell it on their web sites. I don't recall it at the Chemist shop.I
searched the UC Berkely site and nothing came up.
John
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Quoted message said:

J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related Articles, Links

Effects of N-acetylcysteine treatment on oxidative stress in acetic
acid-induced experimental colitis in rats.

Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M, Aydin HH.

Department of General Surgery, Ege University School of Medicine,
Bornova, Izmir, Turkey. [email hidden]

We assessed the possible protective effects of N-acetylcysteine (NAC)
against toxic damage in the rat colon. Two doses of NAC (20 mg/kg and
100 mg/kg) given for 2 days and 7 days after acetic acid administration
(to induce colitis) were tested. NAC was dissolved in saline and
administered locally (intracolonic), systemically (intraperitoneal) or
in a combination (intracolonic and intraperitoneal). Several
parameters, including macroscopic and histopathological scores and
myeloperoxidase, glutathione and nitric oxide concentrations were
measured using standard assay procedures. Treatment with 100 mg/kg NAC
for 7 days significantly decreased tissue myeloperoxidase, glutathione
and nitric oxide concentrations. The 20 mg/kg dose had no protective
effects. The data indicate that NAC substantially reduced the degree of
colonic injury, probably by regulating free radical production and
inhibiting inflammation. It may, therefore, have a role in the
treatment of inflammatory bowel disease.

PMID: 15790131 [PubMed - in process]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://herbivore.7h.com

That reply is not worth responding to
"John H" <[email hidden]> wrote in message news:[email hidden]...

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thats par for the course with you John...you get asked what all your whining
is about and you refuse to answer any of it... 🙂
"John H" <[email hidden]> wrote in message news:[email hidden]...

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"John H" <[email hidden]> wrote in message
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As the links writer demonstrates "the Comparative Guide to Nutritional
Supplements " is nothing more than a marketing ploy for the U$ana
Essentials". I doubt that it has changed with the 3rd edition.
I don't doubt that Usana make high quality supplements ( although they
claim 'superior'😉, but I don't think the major non mlm companies would lay
themselves open by being substandard either.
As Berkley University says:
" A multi need not cost more than a few cents a day. You don't need a fancy
multi. Most store-brand and generic products are fine."
http://wellnessletter.com/html/ds/dsMultivitamins.php
John

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thats par for the course with you John...you get asked what all your

whining

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is about and you refuse to answer any of it... 🙂
"John H" <[email hidden]> wrote in message

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Ken.W said:

you keep referring to it's second edition...why is
that? Can you not find anything wrong with the third edition...

The third edition still has the following flaws:

1. In every edition, 1st, 2nd, AND 3rd, the "experts" who made the
recommendations are primarily businessmen who operate supplement
companies. Not a single one of the "experts" holds an academic position
in the nutrition field, plus has NO financial ties to the supplement
industry. Not a single "expert," Ken.

2. NONE of the editions, 1st, 2nd, or 3rd, cites scientific studies
comparing actual people taking one brand of vitamins against actual
people taking anther brand. Nowhere does the book give data
demonstrating that people on the vitamin rated #1 are in any way
healthier than people on vitamin #20: no comparisons of actual people's
longevity, incidence of disease, incidence of disability, days of work
lost to illness, etc., etc.

3. The author of the book asked the "experts" (businessmen) to
recommend the best amounts of each vitamin, and then he took those
recommendations and AVERAGED THEM OUT! And it gets worse: He then
declares that these averages are the "best" amounts of vitamins to
take.

This is completely junk science.

No medical or scientific papers have ever been published proposing that
the "best" dose of a drug or a vitamin or a mineral is the average of
seven different opinions. This is never, never, never done. It's a
joke.

4. The author of the book has openly (on the Web) admitted that he is,
just like Ken, a salesman for USTANKA.

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Or is your only complaint that USANA got top billing again?

Tell us the name of just one scientist or physician with NO financial
ties to the supplement industry who gives USTANKA "top billing."

John H said:

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"John H" <[email hidden]> wrote in message news:[email hidden]...

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More crossposted [censored].

It might be more useful to explain that N-acetylcysteine can be
purchased as things with names like Mucosolvon, and traditionally is
used to unblock catarrh and congestion in colds. Its benefic effect
comes from its ability to increase permeability of mucous membrane and
hence fluidifies mucous secretion (yuck!) You can also buy it as
acetylcysteine in Holland and Barrett. Oh, and BTW, it's the best cure
for a hangover too, since it increases liver function (hence the action
against acetaminophen poisining) and especially of alcohol dehydrogenase
(according to New Scientist magazine).

It might be more useful to explain that N-acetylcysteine can be
purchased as things with names like Mucosolvon, and traditionally is
used to unblock catarrh and congestion in colds. Its benefic effect
comes from its ability to increase permeability of mucous membrane and
hence fluidifies mucous secretion (yuck!) You can also buy it as
acetylcysteine in Holland and Barrett. Oh, and BTW, it's the best cure
for a hangover too, since it increases liver function (hence the action
against acetaminophen poisining) and especially of alcohol dehydrogenase
(according to New Scientist magazine).