Quoted message said:Subject: Re: Mark Probert, David Wright, where have you been?
From: [email hidden] (David Wright)
Date: 12/28/2003 12:12 AM Central Standard Time
Message-id: <[email hidden]>
In article <[email hidden]>, soft-eng
Quoted message said:Hey guys, I haven't seen any coverups starting on this yet:
my.webmd.com95700.htmOpen ↗
Dear Anonymous [censored],
Showing the dangers of Ritalin brings out the best in the debunkers.
Quoted message said:Why are you trying to drag me into this? I've not been particularly active on the whole Ritalin
thing, unlike Mr. Probert. However, he's perfectly right
No, he is making excuses. Rats and mice are used in reseach for a reason. He only uses this excuse
for Ritalin.
-- there's absolutely no way to know if this research
Quoted message said:has any relevance at all to humans.
Using rats and mice for research is unheard of. I guess all research should stop.
Quoted message said:Did you maybe happen to notice this sentence from the article:
It's an open question whether what passes for depression in lab rats has anything to do with
depression in humans.
Did you happen to notice this??
Preteen Ritalin May Increase Depression
Early Use of ADHD Drug Alters Brain, Rat Studies Show
By Daniel DeNoon WebMD Medical News Reviewed By Brunilda Nazario, MD on Monday, December 08, 2003
Dec. 8, 2003 -- Ritalin use in preteen children may lead to depression later in life, studies of
rats suggest.
But early use of Ritalin and other stimulant drugs seems to permanently alter animals' brains.
****That raises concerns that the same thing might be happening in children who take these drugs for
attention deficit hyperactivity disorder (ADHD)***.
The findings come from a research team led by William A. Carlezon Jr., PhD, director of the
behavioral genetics laboratory at McLean Hospital and associate professor at Harvard Medical School.
The study appears in the Dec. 15 issue of Biological Psychiatry
"Rats exposed to Ritalin as juveniles showed large increases in learned-helplessness behavior during
adulthood, suggesting a tendency toward depression," Carlezon says in a news release. "These rats
also showed abnormally high levels of activity in familiar environments. [This] might reflect basic
alterations in the way rats pay attention to their surroundings."
Ritalin, Cocaine, and the Brain
Ritalin and cocaine have different effects on humans.
** But their effects on the brain are very similar.***
When given to preteen rats, both drugs cause long-term changes in behavior.
One of the changes seems good. Early exposure to Ritalin makes rats less responsive to the rewarding
effects of cocaine. But that's not all good. It might mean that the drug short-circuits the brain's
reward system. That would make it difficult to experience pleasure -- a "hallmark symptom of
depression," Carlezon and colleagues note.
The other change seems all bad. Early exposure to Ritalin increases rats' depressive-like responses
in a stress test.
"These experiments suggest that preadolescent exposure to [Ritalin] in rats causes numerous complex
behavioral adaptations, each of which endures into adulthood," Carlezon and colleagues conclude.
"This work highlights the importance of a more thorough understanding of the enduring
neurobiological effects of juvenile exposure to psychotropic drugs."
Those who drug their kids should have real concerns about these issues, rather than dismiss them.
Jan