Quoted message said:Subject: Re: Mark Probert, David Wright, where have you been?
From: [email hidden] (David Wright)
Date: 12/28/2003 12:12 AM Central Standard Time
Message-id: <[email hidden]>
In article <[email hidden]>,
soft-eng said:Hey guys, I haven't seen any coverups starting on this yet:
http://my.webmd.com/content/article/78/95700.htm?z=1728_00000_1000_nb_05
Dear Anonymous [censored],
Showing the dangers of Ritalin brings out the best in the debunkers.
Quoted message said:Why are you trying to drag me into this? I've not been particularly
active on the whole Ritalin thing, unlike Mr. Probert. However, he's
perfectly right
No, he is making excuses. Rats and mice are used in reseach for a reason. He
only uses this excuse for Ritalin.
-- there's absolutely no way to know if this research
Quoted message said:has any relevance at all to humans.
Using rats and mice for research is unheard of. I guess all research should
stop.
Quoted message said:Did you maybe happen to notice
this sentence from the article:
It's an open question whether what passes for depression in lab rats
has anything to do with depression in humans.
Did you happen to notice this??
Preteen Ritalin May Increase Depression
Early Use of ADHD Drug Alters Brain, Rat Studies Show
By Daniel DeNoon
WebMD Medical News Reviewed By Brunilda Nazario, MD
on Monday, December 08, 2003
Dec. 8, 2003 -- Ritalin use in preteen children may lead to depression later in
life, studies of rats suggest.
But early use of Ritalin and other stimulant drugs seems to permanently alter
animals' brains.
****That raises concerns that the same thing might be happening in children who
take these drugs for attention deficit hyperactivity disorder (ADHD)***.
The findings come from a research team led by William A. Carlezon Jr., PhD,
director of the behavioral genetics laboratory at McLean Hospital and associate
professor at Harvard Medical School. The study appears in the Dec. 15 issue of
Biological Psychiatry
"Rats exposed to Ritalin as juveniles showed large increases in
learned-helplessness behavior during adulthood, suggesting a tendency toward
depression," Carlezon says in a news release. "These rats also showed
abnormally high levels of activity in familiar environments. [This] might
reflect basic alterations in the way rats pay attention to their surroundings."
Ritalin, Cocaine, and the Brain
Ritalin and cocaine have different effects on humans.
** But their effects on the brain are very similar.***
When given to preteen rats, both drugs cause long-term changes in behavior.
One of the changes seems good. Early exposure to Ritalin makes rats less
responsive to the rewarding effects of cocaine. But that's not all good. It
might mean that the drug short-circuits the brain's reward system. That would
make it difficult to experience pleasure -- a "hallmark symptom of depression,"
Carlezon and colleagues note.
The other change seems all bad. Early exposure to Ritalin increases rats'
depressive-like responses in a stress test.
"These experiments suggest that preadolescent exposure to [Ritalin] in rats
causes numerous complex behavioral adaptations, each of which endures into
adulthood," Carlezon and colleagues conclude. "This work highlights the
importance of a more thorough understanding of the enduring neurobiological
effects of juvenile exposure to psychotropic drugs."
Those who drug their kids should have real concerns about these issues, rather
than dismiss them.
Jan