General fitness, health and nutrition · Public discussion

Low-carbs to fight prostate cancer?

Diarmid Logan · 2003-10-28T17:50:46+00:00

http://www.nutraingredientsusa.com/news/news.asp?id=7536 Low-carbs to fight prostate cancer? 10/28/03 - A low-carbohydrate diet may be more effective than reducing fat intake for prevention of prostate cancer, suggests a laboratory study by researchers in the US. Previous studies have suggested a link between the amount of saturated fat in the diet and the risk of progression to advanced prostate cancer. But Ada Elgavish and colleagues from the University of Alabama at Birmingham found that carbohydrate intake may be more significant for men wishing to delay progression to advanced prostate cancer. "In the low-fat versus low-carbohydrate debate, we're finding that under conditions in which diet is provided ad libitum, a diet with fewer carbohydrates may be more effective in preventing progression to advanced, lethal prostate cancer than a diet with low fat content," said Dr Elgavish, lead author of the study, presenting the research at this week's AACR meeting, Frontiers in Cancer Prevention Research. "However, the results of this study are preliminary. Men should talk to their doctors before changing their diets," she added. The investigators compared the relative risk of developing advanced prostate cancer with a low-carbohydrate or a low-fat diet provided ad libitum (as much as wished), beginning before tumours developed and continuing until middle age. The study was carried out in TRAMP mice, biologically engineered to develop prostate cancer after puberty, developed by Dr Greenberg and associates at Baylor College of Medicine in Houston. Two groups of TRAMP mice were fed diets containing the same amount of calories, with either 10 per cent or 45 per cent fat (mostly lard). Carbohydrates, mostly corn starch and sucrose, replaced fat in the low-fat diet. Researchers measured food intake and body weight throughout the 23-week study. After the onset of middle age, mice fed the 45 per cent fat diet had a consistently higher body weight due to higher body fat. When the study ended, 95 per cent of the mice fed the 45 per cent fat diet had survived, compared with only 68.2 per cent of those fed with the 10 per cent fat diet. In addition, the percentage of mice with advanced prostate cancer in the 45 per cent fat group was one-third of that in the group fed the 10 per cent fat diet, reported the researcher. If the results are confirmed in humans, they could provoke a shift in thinking on prostate cancer prevention. Last year researchers from the Fred Hutchinson Cancer Research Center reported finding decreased risk for late-stage prostate cancer in men on low-fat and moderate calcium diets. Numerous other studies support a low-fat, high fibre diet, (advised by the Pritikin programme), to keep prostate cancer at bay. The new study suggests more research is needed to clarify advice for prostate cancer patients. http://www.aacr.org/2003prevention.asp

Started by Diarmid Logan · 28 October 2003 · Last activity 1 November 2003 · 6 posts · 739 views

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Original section: General fitness, health and nutrition
Published: 28 October 2003
Last activity: 1 November 2003
Original author: Diarmid Logan
Posts: 6
Discussion status: Public discussion
Total views: 739
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Original post
Diarmid Logan
Archived post

28 October 2003, 17:50 UTC #1

nutraingredientsusa.comnews.asp
Low-carbs to fight prostate cancer?
10/28/03 - A low-carbohydrate diet may be more effective than reducing fat intake for prevention of
prostate cancer, suggests a laboratory study by researchers in the US.
Previous studies have suggested a link between the amount of saturated fat in the diet and the risk
of progression to advanced prostate cancer.
But Ada Elgavish and colleagues from the University of Alabama at Birmingham found that carbohydrate
intake may be more significant for men wishing to delay progression to advanced prostate cancer.
"In the low-fat versus low-carbohydrate debate, we're finding that under conditions in which diet
is provided ad libitum, a diet with fewer carbohydrates may be more effective in preventing
progression to advanced, lethal prostate cancer than a diet with low fat content," said Dr
Elgavish, lead author of the study, presenting the research at this week's AACR meeting, Frontiers
in Cancer Prevention Research.
"However, the results of this study are preliminary. Men should talk to their doctors before
changing their diets," she added.
The investigators compared the relative risk of developing advanced prostate cancer with a
low-carbohydrate or a low-fat diet provided ad libitum (as much as wished), beginning before tumours
developed and continuing until middle age.
The study was carried out in TRAMP mice, biologically engineered to develop prostate cancer after
puberty, developed by Dr Greenberg and associates at Baylor College of Medicine in Houston. Two
groups of TRAMP mice were fed diets containing the same amount of calories, with either 10 per cent
or 45 per cent fat (mostly lard). Carbohydrates, mostly corn starch and sucrose, replaced fat in the
low-fat diet.
Researchers measured food intake and body weight throughout the 23-week study.
After the onset of middle age, mice fed the 45 per cent fat diet had a consistently higher body
weight due to higher body fat. When the study ended, 95 per cent of the mice fed the 45 per cent fat
diet had survived, compared with only 68.2 per cent of those fed with the 10 per cent fat diet.
In addition, the percentage of mice with advanced prostate cancer in the 45 per cent fat group was
one-third of that in the group fed the 10 per cent fat diet, reported the researcher.
If the results are confirmed in humans, they could provoke a shift in thinking on prostate cancer
prevention. Last year researchers from the Fred Hutchinson Cancer Research Center reported finding
decreased risk for late-stage prostate cancer in men on low-fat and moderate calcium diets. Numerous
other studies support a low-fat, high fibre diet, (advised by the Pritikin programme), to keep
prostate cancer at bay. The new study suggests more research is needed to clarify advice for
prostate cancer patients.
aacr.org2003prevention.asp

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Patricia Heil
Archived post

28 October 2003, 22:51 UTC #2

First off this is mice. There have been other things that worked in mice but not humans.
Diarmid Logan said:

nutraingredientsusa.comnews.asp
Low-carbs to fight prostate cancer?
10/28/03 - A low-carbohydrate diet may be more effective than reducing fat intake for prevention
of prostate cancer, suggests a laboratory study by researchers in the US.
Previous studies have suggested a link between the amount of saturated fat in the diet and the
risk of progression to advanced prostate cancer.
But Ada Elgavish and colleagues from the University of Alabama at Birmingham found that
carbohydrate intake may be more significant for men wishing to delay progression to advanced
prostate cancer.
"In the low-fat versus low-carbohydrate debate, we're finding that under conditions in which diet
is provided ad libitum, a diet with fewer carbohydrates may be more effective in preventing
progression to advanced, lethal prostate cancer than a diet with low fat content," said Dr
Elgavish, lead author of the study, presenting the research at this week's AACR meeting, Frontiers
in Cancer Prevention Research.
"However, the results of this study are preliminary. Men should talk to their doctors before
changing their diets," she added.
The investigators compared the relative risk of developing advanced prostate cancer with a
low-carbohydrate or a low-fat diet provided ad libitum (as much as wished), beginning before
tumours developed and continuing until middle age.
The study was carried out in TRAMP mice, biologically engineered to develop prostate cancer after
puberty, developed by Dr Greenberg and associates at Baylor College of Medicine in Houston. Two
groups of TRAMP mice were fed diets containing the same amount of calories, with either 10 per
cent or 45 per cent fat (mostly lard). Carbohydrates, mostly corn starch and sucrose, replaced fat
in the low-fat diet.
Researchers measured food intake and body weight throughout the 23-week study.
After the onset of middle age, mice fed the 45 per cent fat diet had a consistently higher body
weight due to higher body fat. When the study ended, 95 per cent of the mice fed the 45 per
cent fat diet had survived, compared with only 68.2 per cent of those fed with the 10 per cent
fat diet.
In addition, the percentage of mice with advanced prostate cancer in the 45 per cent fat group was
one-third of that in the group fed the 10 per cent fat diet, reported the researcher.
If the results are confirmed in humans, they could provoke a shift in thinking on prostate cancer
prevention. Last year researchers from the Fred Hutchinson Cancer Research Center reported finding
decreased risk for late-stage prostate cancer in men on low-fat and moderate calcium diets.
Numerous other studies support a low-fat, high fibre diet, (advised by the Pritikin programme), to
keep prostate cancer at bay. The new study suggests more research is needed to clarify advice for
prostate cancer patients.
aacr.org2003prevention.asp

Report
Nicholas
Archived post

28 October 2003, 22:51 UTC #3

"Patricia Heil" <[email hidden]> ha scritto nel messaggio "]news:[email hidden]...
Quoted message said:

First off this is mice. There have been other things that worked in mice but not humans.
Yeah, this is ridicolous Rats and mice have nothing to do with humans with respect to trophic
features They belong to a difference class compared to primate humans They are not adapted to an
high carb diets of fruits, berries, vegetables, nut and fish In fact, while humans handle fructose
quite well, fructose is quite dangerous to mice, but we know that primates eat fruits whereas I have
never seen rats eating a banana
As Steve Harris says "If you're a rat, you shouldn't eat fructose. Next rat that comes to me for a
health consultation, I'll be sure and council him very well on the issue"
So please, don't even post studies on rats or mice that are supposed to be used for human health,
they're cruelty useless and if one is going to change his/her diet because of rats experiments then
they become even dangerous !!
Nicholas

Report
Ignoramus16911
Archived post

28 October 2003, 23:52 UTC #4

great post. Could not have said it better myself.
i
In article said:

"Patricia Heil" <[email hidden]> ha scritto nel messaggio "]news:[email hidden]...
Quoted message said:

First off this is mice. There have been other things that worked in mice but not humans.
Yeah, this is ridicolous Rats and mice have nothing to do with humans with respect to trophic
features They belong to a difference class compared to primate humans They are not adapted to an
high carb diets of fruits, berries, vegetables, nut and fish In fact, while humans handle fructose
quite well, fructose is quite dangerous to mice, but we know that primates eat fruits whereas I
have never seen rats eating a banana
As Steve Harris says "If you're a rat, you shouldn't eat fructose. Next rat that comes to me for a
health consultation, I'll be sure and council him very well on the issue"
So please, don't even post studies on rats or mice that are supposed to be used for human health,
they're cruelty useless and if one is going to change his/her diet because of rats experiments
then they become even dangerous !!
Nicholas

Report
Duane Storey
Archived post

30 October 2003, 22:57 UTC #5

This wouldn't surprised me.. Prostate cancer and male pattern baldness are two sides of the same
coin.. It's argued that that same coin is related to PCOS in women, which as we know is primarily an
insulin resistance ailment. I've seen a few papers recently that hypothesise about the link between
MBP and insulin resistance.. We know low carb diets are beneficial for people with insulin
resistance, so I don't think it's a big stretch to think that low carb diets may be beneficial for
the prostate as well (and hairloss? let's hope).
When insulin goes up, SHBG goes down, and free T goes up. More free t means more DHT and estrogen,
which affects the prostate.

Report
Pinkot
Archived post

1 November 2003, 16:13 UTC #6

There are several classes of carbohydrates, the refined sugars are carbohydrates but so are the
beans and other legumes which are more complex and have a low clycemic index. Practically everything
we eat contains carbohydrates.
"Duane Storey" <[email hidden]> wrote in message
"]news:[email hidden]...
Quoted message said:
This wouldn't surprised me.. Prostate cancer and male pattern baldness are two sides of the same
coin.. It's argued that that same coin is related to PCOS in women, which as we know is primarily
an insulin resistance ailment. I've seen a few papers recently that hypothesise about the link
between MBP and insulin resistance.. We know low carb diets are beneficial for people with insulin
resistance, so I don't think it's a big stretch to think that low carb diets may be beneficial for
the prostate as well (and hairloss? let's hope).
When insulin goes up, SHBG goes down, and free T goes up. More free t means more DHT and estrogen,
which affects the prostate.

Report

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