Iron Toxicity

Good way to get rid of iron is to give blood.
Anth
"Ian Goddard" <[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

After mentioning potential risks associated with iron intake
above necessary levels to some friends, some of whom seemed
skeptical, I gathered some of the data, which, having
collected, I thought I'd share with folks here...

This review from "Nutrition Today" (5/6/97) by two leading
researchers examines risks associated with iron and concludes
that apart from deficiencies, "There is little reason to support
a general need for iron supplementation in the diet at any age.
[...] don't expose your system to more iron than it needs."
While essential at recommended levels, iron generates toxic
oxygen radicals. It also notes that iron intake is cumulative,
since "iron accumulates in the brain with normal aging."

http://web.archive.org/web/20010901081956/http://pspinformation.com/nutrition/minerals/iron.shtml

Quoted message said:

Iron's possible supporting role in neurological degeneration:

Proceedings of the National Academy of Sciences (May 28, 2002):
"Whereas a decade ago thoughts of metals and Alzheimer's disease
(AD) conjured up thoughts of tossing out your aluminum cookware,
more recently, zinc, copper, and iron have been implicated in
AD pathology."
http://www.pnas.org/cgi/content/full/99/11/7317

Cellular and Molecular Biology (June 2000): "In several
neurodegenerative diseases, iron accumulates at sites of
brain pathology. Since post-mortem examination cannot
distinguish whether iron accumulation caused the damage or
resulted from damage, it is necessary to manipulate iron in
animal and tissue culture models to assess its causal role(s).
[...] iron supplementation to ID rats increased damage and
microgliosis in the above regions. [...] In addition,
iron+zinc supplementation dramatically increased damage to
hippocampal CA1 whereas zinc supplementation alone had no effect."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10875437&dopt=Abstract

Quoted message said:

Journal of Neurochemistry (July 1992): "Iron, a transition
metal possibly involved in the pathogenesis of Parkinson's
disease, was tested for its toxic effects toward cultures of
dissociated rat mesencephalic cells. [...] Altogether, these
results suggest (a) that ferrous iron is a potent neurotoxin
for dopaminergic neurons as well as for other cell types in
dissociated mesencephalic cultures [...]."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1613493&dopt=Abstract

Quoted message said:

Professor James Connor (author of "Nutrition Today" review
quoted at top of post): "Our data had led to the discovery
that the brain's ability to mobilize iron is diminished in
Alzheimer's Disease and in specific regions of the brain
in Parkinson's Disease. This diminished iron mobilization
could lead to increased susceptibility to oxidative damage
and cell death; both of which are prominent features in
Alzheimer's and Parkinson's diseases."

http://www.hmc.psu.edu/depts/old%20pages-kms%20save/neuro/faculty/jrconnor.htm

Quoted message said:

Current Opinion in Chemical Biology (April 4, 2000): "Data
are now rapidly accumulating to show that metallochemical
reactions might be the common denominator underlying
Alzheimer's disease, amyotrophic lateral sclerosis, prion
diseases, cataracts, mitochondrial disorders and Parkinson's
disease. In these disorders, an abnormal reaction between a
protein and a redox-active metal ion (copper or iron)
promotes the formation of reactive oxygen species or radicalization."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=10742195&dopt=Abstract

Quoted message said:

Alzheimer's disease (AD) appears to be associated with
a dysregulation of heavy metals, possibly as a result of
impairment of metallothione (the body's natural defense
against metal toxicity) that may be associated with the
ApoE genetic defect that increases the risk of AD.

Aluminum and Alzheimer's disease:

http://www.google.com/groups?selm=gq8havshkhetd6s78ctbgvc8iev0gtma1n%404ax.com

Quoted message said:

Mercury and Alzheimer's disease:
http://www.google.com/groups?selm=3af37029.2307577%40news.erols.com

http://IanGoddard.net/journal.htm

"To lengthen thy life, lessen thy meals." Ben Franklin

Ongoing CR-monkey-study update: "In the monkeys...those on
reduced feeding since the study started are dying at a rate
that is about half that of the monkeys receiving a full food
ration." Associated Press: Eating less may extend human life.
August 1, 2002 : http://www.msnbc.com/news/788746.asp?0si=-

I've also seen information that iron overload can cause heart problems -
hence the greater percentage of men having problems than women - as women
lose a lot of iron with their menses.
Iron-supplemented baby formula is SCARY.

Virginia
"Forgiveness is easier to obtain than permission."

www.thedesignuniverse.com

"Ian Goddard" <[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

After mentioning potential risks associated with iron intake
above necessary levels to some friends, some of whom seemed
skeptical, I gathered some of the data, which, having
collected, I thought I'd share with folks here...

This review from "Nutrition Today" (5/6/97) by two leading
researchers examines risks associated with iron and concludes
that apart from deficiencies, "There is little reason to support
a general need for iron supplementation in the diet at any age.
[...] don't expose your system to more iron than it needs."
While essential at recommended levels, iron generates toxic
oxygen radicals. It also notes that iron intake is cumulative,
since "iron accumulates in the brain with normal aging."

http://web.archive.org/web/20010901081956/http://pspinformation.com/nutritio
n/minerals/iron.shtml

Quoted message said:

Iron's possible supporting role in neurological degeneration:

Proceedings of the National Academy of Sciences (May 28, 2002):
"Whereas a decade ago thoughts of metals and Alzheimer's disease
(AD) conjured up thoughts of tossing out your aluminum cookware,
more recently, zinc, copper, and iron have been implicated in
AD pathology."
http://www.pnas.org/cgi/content/full/99/11/7317

Cellular and Molecular Biology (June 2000): "In several
neurodegenerative diseases, iron accumulates at sites of
brain pathology. Since post-mortem examination cannot
distinguish whether iron accumulation caused the damage or
resulted from damage, it is necessary to manipulate iron in
animal and tissue culture models to assess its causal role(s).
[...] iron supplementation to ID rats increased damage and
microgliosis in the above regions. [...] In addition,
iron+zinc supplementation dramatically increased damage to
hippocampal CA1 whereas zinc supplementation alone had no effect."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
ds=10875437&dopt=Abstract

Quoted message said:

Journal of Neurochemistry (July 1992): "Iron, a transition
metal possibly involved in the pathogenesis of Parkinson's
disease, was tested for its toxic effects toward cultures of
dissociated rat mesencephalic cells. [...] Altogether, these
results suggest (a) that ferrous iron is a potent neurotoxin
for dopaminergic neurons as well as for other cell types in
dissociated mesencephalic cultures [...]."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
ds=1613493&dopt=Abstract

Quoted message said:

Professor James Connor (author of "Nutrition Today" review
quoted at top of post): "Our data had led to the discovery
that the brain's ability to mobilize iron is diminished in
Alzheimer's Disease and in specific regions of the brain
in Parkinson's Disease. This diminished iron mobilization
could lead to increased susceptibility to oxidative damage
and cell death; both of which are prominent features in
Alzheimer's and Parkinson's diseases."

http://www.hmc.psu.edu/depts/old%20pages-kms%20save/neuro/faculty/jrconnor.h
tm

Quoted message said:

Current Opinion in Chemical Biology (April 4, 2000): "Data
are now rapidly accumulating to show that metallochemical
reactions might be the common denominator underlying
Alzheimer's disease, amyotrophic lateral sclerosis, prion
diseases, cataracts, mitochondrial disorders and Parkinson's
disease. In these disorders, an abnormal reaction between a
protein and a redox-active metal ion (copper or iron)
promotes the formation of reactive oxygen species or radicalization."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_ui
ds=10742195&dopt=Abstract

Quoted message said:

Alzheimer's disease (AD) appears to be associated with
a dysregulation of heavy metals, possibly as a result of
impairment of metallothione (the body's natural defense
against metal toxicity) that may be associated with the
ApoE genetic defect that increases the risk of AD.

Aluminum and Alzheimer's disease:

http://www.google.com/groups?selm=gq8havshkhetd6s78ctbgvc8iev0gtma1n%404ax.c
om

Quoted message said:

Mercury and Alzheimer's disease:
http://www.google.com/groups?selm=3af37029.2307577%40news.erols.com

http://IanGoddard.net/journal.htm

"To lengthen thy life, lessen thy meals." Ben Franklin

Ongoing CR-monkey-study update: "In the monkeys...those on
reduced feeding since the study started are dying at a rate
that is about half that of the monkeys receiving a full food
ration." Associated Press: Eating less may extend human life.
August 1, 2002 : http://www.msnbc.com/news/788746.asp?0si=-

Virginia said:

I've also seen information that iron overload can cause heart problems -
hence the greater percentage of men having problems than women - as women
lose a lot of iron with their menses.

IAN: Indeed, as well as being neurotoxic, iron may
also play a causal role in heart disease. Anything
that generates free radicals has the potential for
widespread harm. From the "Nutrition Today" review:

***********************************************************

[...] there is growing concern that too much iron in our diets may be
related to certain diseases like cancer, cardiovascular disease, and
certain neurologic diseases. [...]

A 1992 prospective study[31] of Finnish men established that an
elevated serum level of ferritin was a significant risk factor for
acute myocardial infarction (AMI). The results of this study are
consistent with a 1972 report that serum ferritin levels are
positively correlated with heart disease.[32] Elevations in serum
ferritin can be (but are not always) reflective of high levels of
stored iron in the body. Menses in young adult women has been reported
to at least partly explain why women are generally at lower risk for
heart disease than men.

[ IAN: The implication being that the loss of iron from menstration
may reduce heart disease, as Virginia noted. Back to the review... ]

Indeed, a Framingham study showed that premenopausal hysterectomy
eliminated the protection against heart disease.[33] Estrogen
replacement therapy alone does not decrease the risk of heart disease
in women or men. Most studies on iron and heart disease focus on
excess iron. Epidemiologic studies have revealed that where iron
deficiency is prevalent in a population, there is a low prevalence of
heart disease. Obviously, the heart requires a constant supply of iron
for normal function, but there is nothing to indicate that a balanced
diet will not provide sufficient iron for normal heart activity.

One other area where increased iron has been considered to increase
cardiovascular problems has been in association with atherogenicity of
low-density lipoprotein (LDL) associated cholesterol. Earlier, we
mentioned how oxidatively damaged proteins function poorly or not at
all. Iron can cause oxidative damage to LDL, causing LDL to be rapidly
cleared from plasma.

Although at first glance, rapid removal of LDL from plasma may appear
to be a positive effect, the rapid uptake appears to present problems
for the endothelial cells surrounding the blood vessel. It is also
thought that incomplete oxidative damage to LDL may render it less
functional but also less likely to be cleared from the plasma. Iron
itself can be found within atherosclerotic lesions.

[...]

31. Salonen JT, Nyyssonen K, Korpela H, Tuomilehto J, Seppanen SR.
High stored iron levels are associated with excess risk of myocardial
infarction. Circulation 1992;86:803-11.

32. Cook JD, finch CA, Smith NJ. Evaluation of the iron status of a
population. Blood 1976;48: 449-54.

33. Gordon T, Kannel WB, Hjortland MC, McNamara PM. Menopause and
coronary disease: The Framingham Study. Ann Intern Med 1976;85:447-55.

***********************************************************

http://web.archive.org/web/20010901081956/http://pspinformation.com/nutrition/minerals/iron.shtml

Quoted message said:

Quoted message said:

Aluminum and Alzheimer's disease:
http://www.google.com/groups?selm=gq8havshkhetd6s78ctbgvc8iev0gtma1n%404ax.com

Mercury and Alzheimer's disease:
http://www.google.com/groups?selm=3af37029.2307577%40news.erols.com

http://IanGoddard.net/journal.htm

"To lengthen thy life, lessen thy meals." Ben Franklin

Ongoing CR-monkey-study update: "In the monkeys...those on
reduced feeding since the study started are dying at a rate
that is about half that of the monkeys receiving a full food
ration." Associated Press: Eating less may extend human life.
August 1, 2002 : http://www.msnbc.com/news/788746.asp?0si=-

"Virginia" <[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

I've also seen information that iron overload can cause

heart problems -

Quoted message said:

hence the greater percentage of men having problems than

women - as women

Quoted message said:

lose a lot of iron with their menses.

That's in adults. It takes a decade at least to build up
that much iron.

Quoted message said:

Iron-supplemented baby formula is SCARY.

Only to the uninformed. Unless you're still drinking it, my
dear? Maybe giving it to hubby on the side?

SBH

"Steve Harris" <[email hidden]> wrote in message news:<[email hidden]>...

Quoted message said:

"Virginia" <[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

I've also seen information that iron overload can cause

heart problems -

Quoted message said:

hence the greater percentage of men having problems than

women - as women

Quoted message said:

lose a lot of iron with their menses.

That's in adults. It takes a decade at least to build up
that much iron.

Quoted message said:

Iron-supplemented baby formula is SCARY.

Only to the uninformed. Unless you're still drinking it, my
dear? Maybe giving it to hubby on the side?

SBH

Dr. Harris is correct in his assessment that growing babies need extra
iron to prevent iron deficiency anemia.

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
http://www.heartmdphd.com

Quoted message said:

Subject: Re: Iron Toxicity
From: [email hidden] (Dr. Andrew B. Chung, MD/PhD)
Date: 8/3/2003 11:23 PM Mountain Daylight Time
Message-id: <[email hidden]>

"Steve Harris" <[email hidden]> wrote in message
news:<[email hidden]>...

Quoted message said:

"Virginia" <[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

I've also seen information that iron overload can cause

heart problems -

Quoted message said:

hence the greater percentage of men having problems than

women - as women

Quoted message said:

lose a lot of iron with their menses.

That's in adults. It takes a decade at least to build up
that much iron.

Quoted message said:

Iron-supplemented baby formula is SCARY.

Only to the uninformed. Unless you're still drinking it, my
dear? Maybe giving it to hubby on the side?

SBH

Dr. Harris is correct in his assessment that growing babies need extra
iron to prevent iron deficiency anemia.

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
http://www.heartmdphd.com

Try to keep up .. doc ..

http://www.docguide.com/gpc.nsf/doc?CreateDocument&n=95&id=48DDE4A73E09A96
9852568880078C249&cond=Nutritional%2fMetabolic%20Other&t=12-30-43;PM&l=New
s&u=/news/content.nsf/PaperFrameSet?OpenForm&refid=2&id=48DDE4A73E09A96985
2568880078C249&newsid=8525697700573E1885256C8900214975&u=http://www.ncbi.n
lm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12468607&dop
t=Abstract&ref=/news/content.nsf/news/8525697700573E1885256C8900214975?Ope
nDocument&id=48DDE4A73E09A969852568880078C249&c=Nutritional%2fMetabolic%20
Other&count=10

1: J Nutr. 2002 Dec;132(12):3680-6. Related Articles, Links

The diagnostic criteria for iron deficiency in infants should be reevaluated.

Domellof M, Dewey KG, Lonnerdal B, Cohen RJ, Hernell O.

Department of Clinical Sciences, Pediatrics, Umea University, Sweden.
[email hidden]

Diagnostic criteria for iron deficiency (ID) and iron deficiency anemia (IDA)
in infants are poorly defined. Our aim was to establish appropriate cut-off
values for hemoglobin (Hb), plasma ferritin, erythrocyte mean cell volume
(MCV), zinc protoporphyrin (ZPP) and soluble transferrin receptors (TfR) in
infancy. Exclusively breast-fed infants (n = 263) in Honduras and Sweden were
randomly assigned to receive iron supplementation or placebo, and blood samples
were obtained at 4, 6 and 9 mo of age. Reference ranges were determined using
three different approaches for defining iron-replete infants. The usefulness of
several variables for predicting the Hb response to iron was evaluated. We
found the following 2 SD cut-off values in iron-replete infants: Hb <105 g/L at
4-6 mo and <100 g/L at 9 mo; ZPP >75 micro mol/mol heme at 4-6 mo and >90 micro
mol/mol heme at 9 mo; ferritin <20 micro g/L at 4 mo, <9 micro g/L at 6 mo and
<5 micro g/L at 9 mo; and TfR >11 mg/L at 4-9 mo. The Hb response to iron was
not a useful definition of IDA at 4 mo of age. Hb, MCV and ZPP at 6 mo as well
as growth variables predicted the Hb response at 6-9 mo, but ferritin and TfR
at 6 mo did not. We conclude that there is need for a reevaluation of the
definitions of ID and IDA in infants.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 12468607 [PubMed - indexed for MEDLINE]

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