Iron / infection

"Although iron is required to sustain life, its free concentration and
metabolism have to be tightly regulated. This is achieved through a
variety of
iron-binding proteins including transferrin and ferritin."

Contridicts core of iron causes all disease thesis,ie. iron is not
controled and we must avoid consuming it and use methods to reduce it.

Quoted message said:

Subject: Re: Iron / infection
From: [email hidden]
Date: 11/9/2004 8:27 AM Mountain Standard Time
Message-id: <[email hidden]>

"Although iron is required to sustain life, its free concentration and
metabolism have to be tightly regulated. This is achieved through a
variety of
iron-binding proteins including transferrin and ferritin."

Contridicts core of iron causes all disease thesis,ie. iron is not
controled and we must avoid consuming it and use methods to reduce it.

Comments from .. markd . noted .. and filed ..

Nature. 2004 Nov 7 [Epub ahead of print] Links

Lipocalin 2 mediates an innate immune response to bacterial infection by
sequestrating iron.

Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem
A.

[1] Institute for Systems Biology, Seattle, Washington 98103, USA [2] Institute
for Cancer Research and Molecular Medicine, Norwegian University of Science and
Technology, 7489 Trondheim, Norway [3] These authors contributed equally to
this work.

Although iron is required to sustain life, its free concentration and
metabolism have to be tightly regulated. This is achieved through a variety of
iron-binding proteins including transferrin and ferritin. During infection,
bacteria acquire much of their iron from the host by synthesizing siderophores
that scavenge iron and transport it into the pathogen. We recently demonstrated
that enterochelin, a bacterial catecholate siderophore, binds to the host
protein lipocalin 2 (ref. 5). Here, we show that this event is pivotal in the
innate immune response to bacterial infection. Upon encountering invading
bacteria the Toll-like receptors on immune cells stimulate the transcription,
translation and secretion of lipocalin 2; secreted lipocalin 2 then limits
bacterial growth by sequestrating the iron-laden siderophore. Our finding
represents a new component of the innate immune system and the acute phase
response to infection.

PMID: 15531878 [PubMed - as supplied by publisher]

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Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

Several contridictions to iron thesis have been presented by it's inventer
himself. How many contridictions constitute a case of the thesis having
failed? How does one know if the iron thesis is a failure, what info do
we need and what would it have to look like to accept it as the final nail
in the thesis coffin?

Quoted message said:

Subject: Re: Iron / infection
From: [email hidden]
Date: 11/10/2004 7:01 AM Mountain Standard Time
Message-id: <[email hidden]>

Several contridictions to iron thesis have been presented by it's inventer
himself. How many contridictions constitute a case of the thesis having
failed? How does one know if the iron thesis is a failure, what info do
we need and what would it have to look like to accept it as the final nail
in the thesis coffin?

The SHEER NUMBER of researchers investigating the implications of iron .. rules
out .. YOU .. in .. the hypothesis ..

As if YOU .. are going to go it .. alone .. ?

Heh .. heh ...

Nature. 2004 Nov 7 [Epub ahead of print] Links

Lipocalin 2 mediates an innate immune response to bacterial infection by
sequestrating iron.

Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem
A.

[1] Institute for Systems Biology, Seattle, Washington 98103, USA [2] Institute
for Cancer Research and Molecular Medicine, Norwegian University of Science and
Technology, 7489 Trondheim, Norway [3] These authors contributed equally to
this work.

Although iron is required to sustain life, its free concentration and
metabolism have to be tightly regulated. This is achieved through a variety of
iron-binding proteins including transferrin and ferritin. During infection,
bacteria acquire much of their iron from the host by synthesizing siderophores
that scavenge iron and transport it into the pathogen. We recently demonstrated
that enterochelin, a bacterial catecholate siderophore, binds to the host
protein lipocalin 2 (ref. 5). Here, we show that this event is pivotal in the
innate immune response to bacterial infection. Upon encountering invading
bacteria the Toll-like receptors on immune cells stimulate the transcription,
translation and secretion of lipocalin 2; secreted lipocalin 2 then limits
bacterial growth by sequestrating the iron-laden siderophore. Our finding
represents a new component of the innate immune system and the acute phase
response to infection.

PMID: 15531878 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------
------

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

"The SHEER NUMBER of researchers investigating the implications of iron ..
rules
out .. YOU .. in .. the hypothesis .."

This has always been clear, a confusion that because others are looking at
all aspects of biochem in humans that any mention of iron is a mark of
some support for your invented thesis,ie. that iron is the cause for all
disease. At best this is a confusion about how science works, at worst,
well ... There is no where in all the reams of articles you have posted
is there even the mere wisper that anyone, anyone in the whole worlds
knows about or cares about your invented thesis about iron. If you think
this is in error, submit it for publication, or just maybe you have and
the results will never be disclosed? You avoid the question, how many
articles to the contrary and how many instances of you posting yourself
contridictions to your own thesis will constitute clear basis for
rejecting it? This is not an empty question, it is at the heart of how
science is done, and you should be prepared to answerit.