Iron in the guts

Quoted message said:

<<snip>>
functions as an effective iron-binding and radical-scavenging
antioxidant
<<snip>>

J Insect Physiol. 2004 Sep;50(9):783-90. Related Articles, Links

Antioxidant defense of the midgut epithelium by the peritrophic
envelope in caterpillars.

Barbehenn RV, Stannard J.

Department of Molecular, Cellular and Developmental Biology, University
of Michigan, Ann Arbor, MI 48109-1048, USA. [email hidden]

The peritrophic envelope (PE) is an extracellular matrix that is
secreted by the midgut epithelium in most arthropods. In addition to
protecting the midgut epithelium from abrasive food particles and
microbial pathogens, in vitro experiments have suggested that the PE
functions as a radical-scavenging antioxidant in caterpillars. This
study tested the hypothesis that the PE is a "sacrificial antioxidant"
in vivo in caterpillars. As a sacrificial antioxidant, the PE would (1)
bind catalytic metal ions, (2) become oxidized itself, and (3) protect
the midgut epithelium from oxidative damage. Each of these functions
was supported by our results: the PE in Malacosoma disstria adsorbed
increased amounts of iron as the concentration of iron was increased in
its diet. Iron adsorption by the PE helped protect the midgut
epithelium of M. disstria from oxidative damage over a wide range of
ingested iron concentrations. Secondly, while the midgut epithelium was
protected, protein oxidation in the PE increased 108% when tannic acid
was oxidized in the endoperitrophic space. Finally, when the formation
of the PE was inhibited by Calcofluor, protein carbonyls in the midgut
epithelia of M. disstria and Orgyia leucostigma increased by two- to
threefold. We conclude that the PE functions as an effective
iron-binding and radical-scavenging antioxidant that protects the
midgut epithelia of caterpillars.

PMID: 15350499 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------
Who loves ya.
Tom

Let me get this straight. First they say we Crohnies are to
eat parasitic worms. Now they want us to add in a side
order of caterpillars and our guts should then stay in
remission? Sounds ever so yummy! 🙂

BB

I think what might be happening is .. if one were to extrapolate the
gut of the caterpillar to the gut of a human .. the gut in the
caterpillar is 'protected' by the 'film' .. PE .. and when this is
oxidized by .. iron .. the 'ability' to 'protect' the gut .. is
diminished / destroyed.

So in essence when the 'film' in a person with IBD / IBS is either
missing or destroyed .. the gut is no longer protected by the 'film'..
and you get DESTRUCTION of flesh / gut lining ..

This theory is given a bit of credence when one looks at the recent
studies which show phytic acid , a natural iron binder , has
anti-inflammatory / anti-ulcer effects .. and ALSO deferoxamine ANOTHER
... iron .. binder .. ?

The fact one piece of white bread contains about a gram of iron .. ?

http://tinyurl.com/4t5xb

Aliment Pharmacol Ther. 2000 Sep;14(9):1163-8.

Effects of iron and iron chelation in vitro on mucosal oxidant activity
in ulcerative colitis.

The effects of desferrioxamine and 1,10-phenanthroline on the
chemiluminescence of biopsies from patients with ulcerative colitis
suggest that a clinical trial of topical iron chelation in active
disease is indicated.

PMID: 10971233

http://tinyurl.com/3rgjg

Indian J Exp Biol. 2004 Feb;42(2):179-85. Related Articles, Links

Antiinflammatory and antiulcer activities of phytic acid in rats.

These results suggested that gastro-protective effect of PA could be
mediated by its antioxidant activity and cytoprotection of gastric
mucosa.

PMID: 15282951

Who loves ya.
Tom

BikerBabe wrote on 1/3/05 2:15 AM:

Quoted message said:

Let me get this straight. First they say we Crohnies are to
eat parasitic worms. Now they want us to add in a side
order of caterpillars and our guts should then stay in
remission?

No, no, you misread it. I think it says that your gut won't get rusty if you
eat more iron -- but only if you're a caterpillar. If it wasn't for the
Internet we wouldn't have known about this important breakthrough.

Wayne Marsh Minneapolis, Minnesota, USA
[email hidden]

Careful using those big words like extrapolate. I used it once and some
people in my fan club got really confused by it.

Anyway, the interesting thing to me is the idea that the epithelial layer is
protected by... well something. Therefore the corrolary is that without
whatever is protecting it it can be compromised. I have previously surmised
that one possible mechanism by which the gut becomes inflammed is when the
epithelial is compromised by different things in the diet. One good example
is the type of IBD caused by NSAIDS.

I have also noticed that certain foods or drink seem to exascerbate my
symptoms. I can only conclude from that that these substances somehow
compromise the epithelial layers and possibly expose them to bacterial
infection. That theory received a lot of negative attention when I first
proposed it. But if humans are not totally different from our multi-legged
friends then we too must have some protective mechanisms which keep our
intestines from being broken down or invaded by pathogens. So if these
mechanisms are compromised - well, it just may be one of the etiological
factors for IBD.

Just a thought.

tx
Jeff

<[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

I think what might be happening is .. if one were to extrapolate the
gut of the caterpillar to the gut of a human .. the gut in the
caterpillar is 'protected' by the 'film' .. PE .. and when this is
oxidized by .. iron .. the 'ability' to 'protect' the gut .. is
diminished / destroyed.

So in essence when the 'film' in a person with IBD / IBS is either
missing or destroyed .. the gut is no longer protected by the 'film'..
and you get DESTRUCTION of flesh / gut lining ..

This theory is given a bit of credence when one looks at the recent
studies which show phytic acid , a natural iron binder , has
anti-inflammatory / anti-ulcer effects .. and ALSO deferoxamine ANOTHER
.. iron .. binder .. ?

The fact one piece of white bread contains about a gram of iron .. ?

http://tinyurl.com/4t5xb

Aliment Pharmacol Ther. 2000 Sep;14(9):1163-8.

Effects of iron and iron chelation in vitro on mucosal oxidant activity
in ulcerative colitis.

The effects of desferrioxamine and 1,10-phenanthroline on the
chemiluminescence of biopsies from patients with ulcerative colitis
suggest that a clinical trial of topical iron chelation in active
disease is indicated.

PMID: 10971233

http://tinyurl.com/3rgjg

Indian J Exp Biol. 2004 Feb;42(2):179-85. Related Articles, Links

Antiinflammatory and antiulcer activities of phytic acid in rats.

These results suggested that gastro-protective effect of PA could be
mediated by its antioxidant activity and cytoprotection of gastric
mucosa.

PMID: 15282951

Who loves ya.
Tom

Hey, just ride with your mouth open - you might get cured. lol

Jeff

"BikerBabe" <[email hidden]> wrote in message
news:ec7Cd.6581$232.716@fed1read05...

Quoted message said:

Quoted message said:

<<snip>>
functions as an effective iron-binding and radical-scavenging
antioxidant
<<snip>>

J Insect Physiol. 2004 Sep;50(9):783-90. Related Articles, Links

Antioxidant defense of the midgut epithelium by the peritrophic
envelope in caterpillars.

Barbehenn RV, Stannard J.

Department of Molecular, Cellular and Developmental Biology, University
of Michigan, Ann Arbor, MI 48109-1048, USA. [email hidden]

The peritrophic envelope (PE) is an extracellular matrix that is
secreted by the midgut epithelium in most arthropods. In addition to
protecting the midgut epithelium from abrasive food particles and
microbial pathogens, in vitro experiments have suggested that the PE
functions as a radical-scavenging antioxidant in caterpillars. This
study tested the hypothesis that the PE is a "sacrificial antioxidant"
in vivo in caterpillars. As a sacrificial antioxidant, the PE would (1)
bind catalytic metal ions, (2) become oxidized itself, and (3) protect
the midgut epithelium from oxidative damage. Each of these functions
was supported by our results: the PE in Malacosoma disstria adsorbed
increased amounts of iron as the concentration of iron was increased in
its diet. Iron adsorption by the PE helped protect the midgut
epithelium of M. disstria from oxidative damage over a wide range of
ingested iron concentrations. Secondly, while the midgut epithelium was
protected, protein oxidation in the PE increased 108% when tannic acid
was oxidized in the endoperitrophic space. Finally, when the formation
of the PE was inhibited by Calcofluor, protein carbonyls in the midgut
epithelia of M. disstria and Orgyia leucostigma increased by two- to
threefold. We conclude that the PE functions as an effective
iron-binding and radical-scavenging antioxidant that protects the
midgut epithelia of caterpillars.

PMID: 15350499 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------

------

Quoted message said:

Quoted message said:

Who loves ya.
Tom

Let me get this straight. First they say we Crohnies are to
eat parasitic worms. Now they want us to add in a side
order of caterpillars and our guts should then stay in
remission? Sounds ever so yummy! 🙂

BB

Wayne Marsh said:

BikerBabe wrote on 1/3/05 2:15 AM:

Quoted message said:

Let me get this straight. First they say we Crohnies are to
eat parasitic worms. Now they want us to add in a side
order of caterpillars and our guts should then stay in
remission?

No, no, you misread it. I think it says that your gut won't get rusty if you
eat more iron -- but only if you're a caterpillar. If it wasn't for the
Internet we wouldn't have known about this important breakthrough.

Wayne Marsh Minneapolis, Minnesota, USA
[email hidden]

I told my hubby about this and he's already planning next
Sunday's dinner .. instead of spaghetti noodles he is gonna
use worms and will top it with caterpillar goo. Can we say
yummy? LOL.

If normal eating equals gut pain, what does eating creepy,
crawly things equal? Pain in the stomach from throwing it
all back up? Fun, fun, fun... can't wait to get some.

(Did I mention I'm a little warped in the humor dept? Do
you wanna see the pic of the Xray taking toilet that proved
to me I really can [censored] on command? Heh.)

BB

Wayne Marsh said:

BikerBabe wrote on 1/3/05 2:15 AM:

Quoted message said:

Let me get this straight. First they say we Crohnies are to
eat parasitic worms. Now they want us to add in a side
order of caterpillars and our guts should then stay in
remission?

No, no, you misread it. I think it says that your gut won't get rusty if you
eat more iron -- but only if you're a caterpillar. If it wasn't for the
Internet we wouldn't have known about this important breakthrough.

Wayne Marsh Minneapolis, Minnesota, USA
[email hidden]

I told my hubby about this and he's already planning next
Sunday's dinner .. instead of spaghetti noodles he is gonna
use worms and will top it with caterpillar goo. Can we say
yummy? LOL.

If normal eating equals gut pain, what does eating creepy,
crawly things equal? Pain in the stomach from throwing it
all back up? Fun, fun, fun... can't wait to get some.

(Did I mention I'm a little warped in the humor dept? Do
you wanna see the pic of the Xray taking toilet that proved
to me I really can [censored] on command? Heh.)

BB

Jeff2 said:

Hey, just ride with your mouth open - you might get cured. lol

Jeff

I ride [censored] when on a bike, so it won't be me eating bugs. :P

Seriously, I can't ride anymore after 3 head on car wrecks
thru my life. No way my back is gonna let me ride, so these
days when asked what kind of bike I have, I tell them I ride
a tricycle. Always fun to watch the reactions I get.

Now I'm off to nurse this low grade fever that's decided to
grace me with it's presence the past couple of days making
me feel 'yucky'. (I still think that should be classified a
true medical term, it says so well what we feel. LOL.)

BB

Quoted message said:

"BikerBabe" <[email hidden]> wrote in message
news:ec7Cd.6581$232.716@fed1read05...

Quoted message said:

Quoted message said:

<<snip>>
functions as an effective iron-binding and radical-scavenging
antioxidant
<<snip>>

J Insect Physiol. 2004 Sep;50(9):783-90. Related Articles, Links

Antioxidant defense of the midgut epithelium by the peritrophic
envelope in caterpillars.

Barbehenn RV, Stannard J.

Department of Molecular, Cellular and Developmental Biology, University
of Michigan, Ann Arbor, MI 48109-1048, USA. [email hidden]

The peritrophic envelope (PE) is an extracellular matrix that is
secreted by the midgut epithelium in most arthropods. In addition to
protecting the midgut epithelium from abrasive food particles and
microbial pathogens, in vitro experiments have suggested that the PE
functions as a radical-scavenging antioxidant in caterpillars. This
study tested the hypothesis that the PE is a "sacrificial antioxidant"
in vivo in caterpillars. As a sacrificial antioxidant, the PE would (1)
bind catalytic metal ions, (2) become oxidized itself, and (3) protect
the midgut epithelium from oxidative damage. Each of these functions
was supported by our results: the PE in Malacosoma disstria adsorbed
increased amounts of iron as the concentration of iron was increased in
its diet. Iron adsorption by the PE helped protect the midgut
epithelium of M. disstria from oxidative damage over a wide range of
ingested iron concentrations. Secondly, while the midgut epithelium was
protected, protein oxidation in the PE increased 108% when tannic acid
was oxidized in the endoperitrophic space. Finally, when the formation
of the PE was inhibited by Calcofluor, protein carbonyls in the midgut
epithelia of M. disstria and Orgyia leucostigma increased by two- to
threefold. We conclude that the PE functions as an effective
iron-binding and radical-scavenging antioxidant that protects the
midgut epithelia of caterpillars.

PMID: 15350499 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------

------

Quoted message said:

Quoted message said:

Who loves ya.
Tom

Let me get this straight. First they say we Crohnies are to
eat parasitic worms. Now they want us to add in a side
order of caterpillars and our guts should then stay in
remission? Sounds ever so yummy! 🙂

BB

BikerBabe said:

Jeff2 said:

Hey, just ride with your mouth open - you might get cured. lol

Jeff

I ride [censored] when on a bike, so it won't be me eating bugs. :P

Seriously, I can't ride anymore after 3 head on car wrecks
thru my life. No way my back is gonna let me ride, so these
days when asked what kind of bike I have, I tell them I ride
a tricycle. Always fun to watch the reactions I get.

Now I'm off to nurse this low grade fever that's decided to
grace me with it's presence the past couple of days making
me feel 'yucky'. (I still think that should be classified a
true medical term, it says so well what we feel. LOL.)

I forget which med it is that has as a side effect "feeling weird".
One of the tricyclics?

Jon Miller

On Mon, 03 Jan 2005 01:15:06 -0700, BikerBabe <[email hidden]> wrote:

<cut the [censored]>

Quoted message said:

Let me get this straight. First they say we Crohnies are to
eat parasitic worms. Now they want us to add in a side
order of caterpillars and our guts should then stay in
remission? Sounds ever so yummy! 🙂

Maybe Gummi worms?

Jon Miller

Quoted message said:

Let me get this straight. First they say we Crohnies are to eat parasitic
worms. Now they want us to add in a side order of caterpillars and our
guts should then stay in remission? Sounds ever so yummy! 🙂

BB

Have you ever heard of the saying "Eat [censored] and die?"

I used to work with a programmer many, many years ago. At the end of every
memo (typed back then) he would put the letters:

esadmf

I'll leave it up to you to guess what the mf stood for. He was a very funny
guy.

tx
Jeff

"Paul P" <[email hidden]> wrote in
message news:[email hidden]...

Quoted message said:

Quoted message said:

Let me get this straight. First they say we Crohnies are to eat

parasitic

Quoted message said:

Quoted message said:

worms. Now they want us to add in a side order of caterpillars and our
guts should then stay in remission? Sounds ever so yummy! 🙂

BB

Have you ever heard of the saying "Eat [censored] and die?"