Insulin Resistance

On Mon, 09 Feb 2004 15:45:16 GMT, [email hidden] posted:

Quoted message said:

How is insulin resistance treated

Exercise, and weight loss, unless diabetes has developed. Then it's drugs and even insulin
injections on top of the exercise and weight loss.

Moosh🙂

[email hidden] wrote in message news:<[email hidden]>...

Quoted message said:

How is insulin resistance treated

Quentin Grady <[email hidden]> wrote in message
news:<[email hidden]>...

Quoted message said:

G'day G'day Folks,

Some posters might find the following document useful.

eje.org1490099.pdfOpen ↗

Best wishes,

Interesting stuff. Here is an interesting quote:

"A series of studies (33–36) report on the roles of high glucose concentrations and different free
fatty acids (FFAs) on b-cell proliferation, apoptosis and function in cultured human islets. The
results showed that A series of studies (33–36) report on the roles of high glucose concentrations
and different free fatty acids (FFAs) on b-cell proliferation, apoptosis and function in cultured
human islets. The results showed that prolonged exposure of cultured human islets to high glucose
levels increased b-cell apoptosis in a dose-dependent manner. In addition, chronic exposure of
cultured human islets to the saturated fatty acid palmitic acid results in increased markers of b-
cell apoptosis and decreased b-cell proliferation. However, the mono-unsaturated fatty acids
palmitoleic acid and oleic acid did not affect DNA fragmentation and induced b-cell proliferation.
Moreover when co-supplemented, each of the monounsaturated fatty acids prevented apoptosis,
prevented impairment of b-cell proliferation and improved insulin secretion that was caused by
palmitic acid and/or hyperglycemia. In addition, chronic exposure of cultured human islets to the
saturated fatty acid palmitic acid results in increased markers of b-cell apoptosis and decreased
b-cell proliferation. However, the mono-unsaturated fatty acids palmitoleic acid and oleic acid did
not affect DNA fragmentation and induced b-cell proliferation. Moreover when co-supplemented, each
of the monounsaturated fatty acids prevented apoptosis, prevented impairment of b-cell proliferation
and improved insulin secretion that was caused by palmitic acid and/or hyperglycemia."

Repeat and partial quote: "prolonged exposure of cultured human islets to high glucose levels
increased b-cell apoptosis in a dose-dependent manner."

I don't think this could be any clearer. The more glucose b-cells were exposed to glucose and the
higher the "dose" the more apoptosis (cell death) occurred. I gather that this is the not-so-mysterious-
anymore glucotoxicity that we've heard about. This statement seems to indicate that there is a
*direct* connection between blood sugar (glucose) levels and b-cell death.

Repeat and partial quote: "In addition, chronic exposure of cultured human islets to the saturated
fatty acid palmitic acid results in increased markers of b-cell apoptosis and decreased b-cell
proliferation."

Here we are told that *chronic* exposure to saturated fat cause increased *markers* of b-cell death
and decreased b-cell proliferation. This isn't exactly saying that sat fat causes b-cell death but
only causes an increase in "markers" of b-cell death. Can we assume that non-chronic exposures to
saturated fat does not neceassarily lead to b-cell death or significant increase in markers of b-
cell death?

Repeat and partial quote: "the mono-unsaturated fatty acids palmitoleic acid and oleic acid did not
affect DNA fragmentation and induced b-cell proliferation. Moreover when co-supplemented, each of
the monounsaturated fatty acids prevented apoptosis, prevented impairment of b-cell proliferation
and improved insulin secretion that was caused by palmitic acid and/or hyperglycemia."

Mono-unsaturated fats prevented b-cell death and prevented b-cells from suffering impaired
proliferation and it improved insulin secretion.

In conclusion,

1) Glucose impairs or kills b-cells directly dependent upon the dose of glucose. Note that all
carbs in the diet are converted to glucose. The more the refined carbs the higher the blood
glucose levels.

2) Chronic levels of saturated fats cause some stress to b-cells.

3) Mono-unsaturated fats protect and is necessary for the health of b-cells.

Generally speaking, carbs cause b-cell death, fats protect against it.

Interesting how the authors make the statements quoted above and then ignore the ramifications of
their findings related to glucose and they spend most of their discussion on fats. Its right under
their noses.

TC

Once upon a time, our fellow [email hidden] rambled on about "Insulin Resistance." Our
champion De-Medicalizing in sci.med.nutrition retorts, thusly ...

Quoted message said:

How is insulin resistance treated

Exercise, ... exercise, and even more exercise. 🙂

Magnesium supplements.

Weight lost, of course.
--
John Gohde,
Feeling Great and Better than Ever!

Natural therapy is the treatment method used by advocates of natural
health.
tutorials.naturalhealthperspective.comnatural therapy.htmlOpen ↗

Places to check first:
aace.comfindings.phpOpen ↗
aace.comACEIRSPositionStatement.pdfOpen ↗
Then review:
medscape.com467200 printOpen ↗
cardiab.com3Open ↗
drmirkin.comD222.htmlOpen ↗

=====================
<[email hidden]> wrote in message "]news:[email hidden]...

Quoted message said:

How is insulin resistance treated

"J Stutzmann" <[email hidden]> wrote in message news:<[email hidden]>...

Quoted message said:

Places to check first: aace.comfindings.phpOpen ↗
aace.comACEIRSPositionStatement.pdfOpen ↗ Then review:
medscape.com467200 printOpen ↗ cardiab.com3Open ↗
drmirkin.comD222.htmlOpen ↗

=====================
<[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

How is insulin resistance treated

The first two references are to this group"

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS

These are their corporate sponsors:

aace.comCAP.phpOpen ↗

TC