high cholesterol has a genetic basis?

x-no-archive: yes

conrad said:

Is there a pubmed paper that describes high cholesterol
levels have a genetic basis?

I've heard that even though some people eat right
and exercise regularly, they still have high levels of
cholesterol. I'm looking to determine the validity
of this claim.

Nah. Most folks are eating what they're told is right, but it's all wrong.

The tendency toward dyslipidemia may be inherited, but that doesn't mean
that the right diet won't fix it for most folks.

Susan

Well, then you would have do a proper experiment, controlling for all
potentially relevant factors, which won't be easy or cheap. On the
other hand, you can just do some research and you'll see that only
oxidized LDL is going to cause problems, not cholesterol. It's
explained on my free site:

http://groups.msn.com/TheScientificDebateForum-

conrad said:

I've heard that even though some people eat right
and exercise regularly, they still have high levels of
cholesterol. I'm looking to determine the validity
of this claim.

If you search for "familial hypercholesterolaemia" you'll find some.
The two broad defects are insufficient cell surface LDL receptors or
a defect in the apolipoprotein which binds to the LDL receptor. Either
way the LDL stays in the blood so levels increase over time. Rats with
an apolipoprotein disorder they will get high blood cholesterol even
on a fat-free diet.

MattLB

MattLB said:

conrad said:

I've heard that even though some people eat right
and exercise regularly, they still have high levels of
cholesterol. I'm looking to determine the validity
of this claim.

If you search for "familial hypercholesterolaemia" you'll find some.
The two broad defects are insufficient cell surface LDL receptors or
a defect in the apolipoprotein which binds to the LDL receptor. Either
way the LDL stays in the blood so levels increase over time. Rats with
an apolipoprotein disorder they will get high blood cholesterol even
on a fat-free diet.

MattLB

There is also familial combined hyperlipidemia and familial
hypertriglyceridemia. There are also people who have inherited a
mutation that causes very low HDL.

There are people with heterozygous familial hypercholesterolemia
(heFH) who do not have an LDL receptor or ApoB mutation. They are
still discovering other mutations that cause the heFH phenotype
(elevated LDL from birth, usually in the 200s). HeFH cannot be
controlled with diet and exercise only.

Marilyn

Marilyn

MarilynMann said:

MattLB said:

On Jun 18, 2:12 am, conrad <[email hidden]> wrote:

Quoted message said:

Quoted message said:

I've heard that even though some people eat right
and exercise regularly, they still have high levels of
cholesterol. I'm looking to determine the validity
of this claim.

Quoted message said:

If you search for "familial hypercholesterolaemia" you'll find some.
The two broad defects are insufficient cell surface LDL receptors or
a defect in the apolipoprotein which binds to the LDL receptor. Either
way the LDL stays in the blood so levels increase over time. Rats with
an apolipoprotein disorder they will get high blood cholesterol even
on a fat-free diet.

Quoted message said:

MattLB

There is also familial combined hyperlipidemia and familial
hypertriglyceridemia. There are also people who have inherited a
mutation that causes very low HDL.

There are people with heterozygous familial hypercholesterolemia
(heFH) who do not have an LDL receptor or ApoB mutation. They are
still discovering other mutations that cause the heFH phenotype
(elevated LDL from birth, usually in the 200s). HeFH cannot be
controlled with diet and exercise only.

Marilyn

Marilyn

Then there is the simple common sense that families tend to share food
and diet and a bad diet throughout many generations will cause similar
physical problems to all concerned.

Or consider that we genetically evolved with little or no refined
carbs in the diet. We are genetically wired to not thrive on high
refined-carb diets.