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HGH and Heart Attacks

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Road Cycling
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8 August 2004
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B. Lafferty
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  1. Interesting article from the Guardian.
    IOC 'four years late' catching cheats

    Duncan Mackay - Athletics Correspondent
    Sunday August 8, 2004

    The Observer

    Olympics chiefs could have introduced a test for the most widely abused drug
    in sport four years ago, but instead allowed athletes to continue using it
    without fear of detection, according to a leading British scientist.
    Professor Peter Sonksen, who did much of the work on trying to find ways to
    catch athletes using human growth hormone - known as 'the drug of champions'
    and particularly popular among sprinters - says the International Olympic
    Committee shied away from taking a hard-line stance 'for political reasons'.

    Human growth hormone (HGH) can trigger huge increases in muscle growth and
    has been around for about 20 years. While it has been widely used by
    athletes in several sports, officials have struggled to come up with a test
    for it.

    [censored] Pound, chairman of the World Anti-Doping Agency, is confident that a
    new method of detecting the substance will be available when the Olympics
    open in Athens in five days, following extensive and expensive worldwide
    research, including at Southampton University.

    But Professor Sonksen, who carried out four years of research into the drug
    at St Thomas' Hospital, London before the Sydney Olympics, says, 'There is
    nothing new in the [2004] science, just the dotting of a few i's and
    crossing a few t's.'

    Sonksen headed a research project called GH2000, and claims that his team's
    findings delivered six months before the 2000 Games were as advanced as any
    subsequent work on growth hormone.

    'It [the 2004 project] has made our work on GH2000 rock solid with more peer
    review,' he said. 'But there's no new science in it from what GH2000
    delivered six months before the Sydney Olympics. I can say this now that I
    am no longer on the IOC anti-doping commission, but I feel very badly let
    down by the IOC.

    'They gave us a $1million grant to finish off the work four years ago and
    then they took it away. It was all for political reasons, because of a
    disagreement between Prince Alexandre de Merode, the [then] head of the
    IOC's anti-doping commission, and Juan Antonio Samaranch [then IOC
    president].

    'Prince de Merode did a lot of good things during his time in office, but he
    also let himself down badly on a number of occasions. It was the Prince who
    got the funding for the research work in the first place, but if it wasn't
    for him taking back that grant, we could have had a growth hormone test in
    place four years ago.'

    HGH, which was originally developed to assist children with retarded growth,
    is believed to be especially popular with sprinters.

    Tim Montgomery, the world 100metres record holder, testified under oath in
    San Francisco last October that he had used the drug, as did Ben Johnson
    during a government inquiry in Canada 15 years ago.

    It has also been alleged by her former husband that the triple Olympic
    champion Marion Jones injected the drug before and during the Sydney
    Olympics. She has denied the claims of CJ Hunter, the 1999 world shot put
    champion.

    There have been several cases in the United States of former sports stars
    developing heart and liver complaints, and some cancers, leading to their
    deaths in their 40s and 50s. HGH is believed to also make the heart and
    other organs continue to grow, sometimes to unhealthy sizes.

    It is this that has left a shadow over the death, at just 38, of Florence
    Griffith Joyner. The American heroine of the 1988 Olympics died 10 years
    later after an apparent heart seizure in her sleep.

    Flo-Jo had transformed her body in her mid-20s and was later accused of
    using HGH. Her post-mortem showed some signs of excessive growth of her
    organs, including her heart. Her death may have been a direct result of drug
    use.

    Sonksen has also criticised UK Sport for forcing the head of its ethics
    department out of the organisation. Michele Verroken officially left the
    organisation last month after being effectively sacked because she had
    called for an independent anti-doping agency in Britain.

    'Anti-doping in sport has been a huge mess for a long time. It is a very
    complicated and difficult area, but Michele has devoted her life to working
    on it. The way she was treated was disgraceful. UK Sport is a very political
    body and it seems to me that science and ethics comes a long way down its
    priority list.

    'The United States Anti-Doping Agency was set up four years ago and is a
    tightly organised, well run body, but, most importantly, it is separate from
    the sports bodies and from those bodies that sponsor or fund the sports and
    that is the sort of thing we need in this country.

    'An independent anti-doping agency was what Michele was arguing for and I am
    right behind her on that. But I suspect that was one of the reasons why they
    got rid of her. As a civil servant, she possibly spoke her mind too freely.

    'But then, having politicians running sport is just bad news.'

    http://sport.guardian.co.uk/olympics2004/story/0,14912,1278571,00.html

  2. B. Lafferty said:

    Interesting article from the Guardian.
    IOC 'four years late' catching cheats
    http://sport.guardian.co.uk/olympics2004/story/0,14912,1278571,00.html

    In the Economist on "Drugs and the Olympics":
    http://www.economist.com/printedition/displaystory.cfm?Story_ID=3062111
    Is that the whole article..? Seems like an introduction to an article.

  3. Ewoud Dronkert said:
    B. Lafferty said:

    Interesting article from the Guardian.
    IOC 'four years late' catching cheats
    http://sport.guardian.co.uk/olympics2004/story/0,14912,1278571,00.html

    In the Economist on "Drugs and the Olympics":
    http://www.economist.com/printedition/displaystory.cfm?Story_ID=3062111
    Is that the whole article..? Seems like an introduction to an article.

    There is another article about 4 pages long further into the paper.

    I like the quote 'America is the new East Germany'... funnny to think of
    you guys driving Trabbies and mainlining steroids.

  4. David Off said:


    Ewoud Dronkert wrote:

    Quoted message said:
    Quoted message said:

    In the Economist on "Drugs and the Olympics":
    http://www.economist.com/printedition/displaystory.cfm?Story_ID=3062111
    Is that the whole article..? Seems like an introduction to an article.

    There is another article about 4 pages long further into the paper.

    http://www.economist.com/world/displaystory.cfm?story_id=3060826

    don't know if that will be in depth enough for ewoud though (not being
    sarcastic here)
    h

  5. h squared said:

    http://www.economist.com/world/displaystory.cfm?story_id=3060826

    don't know if that will be in depth enough for ewoud though (not
    being sarcastic here)

    Thanks. Interesting to note that the whole article is essentially a
    sales pitch for Pounding [censored]'s book.

  6. "B. Lafferty" <[email hidden]> wrote in message news:<[email hidden]>...

    Quoted message said:

    Interesting article from the Guardian.
    IOC 'four years late' catching cheats

    Duncan Mackay - Athletics Correspondent
    Sunday August 8, 2004

    The Observer

    Olympics chiefs could have introduced a test for the most widely abused drug
    in sport four years ago, but instead allowed athletes to continue using it
    without fear of detection, according to a leading British scientist.
    Professor Peter Sonksen, who did much of the work on trying to find ways to
    catch athletes using human growth hormone - known as 'the drug of champions'
    and particularly popular among sprinters - says the International Olympic
    Committee shied away from taking a hard-line stance 'for political reasons'.

    Human growth hormone (HGH) can trigger huge increases in muscle growth and
    has been around for about 20 years. While it has been widely used by
    athletes in several sports, officials have struggled to come up with a test
    for it.

    Can someone please provide a scientific reference that backs up the
    claim that HGH triggers HUGE muscle growth? I was under the
    impression that only steroids did that.

  7. "PedalChick" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    "B. Lafferty" <[email hidden]> wrote in message


    news:<[email hidden]>...

    Quoted message said:
    Quoted message said:

    Interesting article from the Guardian.
    IOC 'four years late' catching cheats

    Duncan Mackay - Athletics Correspondent
    Sunday August 8, 2004

    The Observer

    Olympics chiefs could have introduced a test for the most widely abused


    drug

    Quoted message said:
    Quoted message said:

    in sport four years ago, but instead allowed athletes to continue using


    it

    Quoted message said:
    Quoted message said:

    without fear of detection, according to a leading British scientist.
    Professor Peter Sonksen, who did much of the work on trying to find ways


    to

    Quoted message said:
    Quoted message said:

    catch athletes using human growth hormone - known as 'the drug of


    champions'

    Quoted message said:
    Quoted message said:

    and particularly popular among sprinters - says the International


    Olympic

    Quoted message said:
    Quoted message said:

    Committee shied away from taking a hard-line stance 'for political


    reasons'.

    Quoted message said:
    Quoted message said:


    Human growth hormone (HGH) can trigger huge increases in muscle growth


    and

    Quoted message said:
    Quoted message said:

    has been around for about 20 years. While it has been widely used by
    athletes in several sports, officials have struggled to come up with a


    test

    Quoted message said:
    Quoted message said:

    for it.

    Can someone please provide a scientific reference that backs up the
    claim that HGH triggers HUGE muscle growth? I was under the
    impression that only steroids did that.

    That claim has apparently not been proved by any research. Stacking hGH
    with anabolic is another issue. A third issue is its possible effectiveness
    in promoting tissue repair making it possible to train harder. Even if hGH
    has no demonstrable effect, that doesn't mean its perceived effect doesn't
    drive elite athletes to use is.

    Take a look at:
    http://www.endocrine-society.gr/hormones/pdf/1_2004/teyx37-45.pdf

  8. PedalChick said:

    "B. Lafferty" <[email hidden]> wrote in message news:<[email hidden]>...

    Quoted message said:

    Interesting article from the Guardian.
    IOC 'four years late' catching cheats

    Duncan Mackay - Athletics Correspondent
    Sunday August 8, 2004

    The Observer

    Olympics chiefs could have introduced a test for the most widely abused drug
    in sport four years ago, but instead allowed athletes to continue using it
    without fear of detection, according to a leading British scientist.
    Professor Peter Sonksen, who did much of the work on trying to find ways to
    catch athletes using human growth hormone - known as 'the drug of champions'
    and particularly popular among sprinters - says the International Olympic
    Committee shied away from taking a hard-line stance 'for political reasons'.

    Human growth hormone (HGH) can trigger huge increases in muscle growth and
    has been around for about 20 years. While it has been widely used by
    athletes in several sports, officials have struggled to come up with a test
    for it.

    Can someone please provide a scientific reference that backs up the
    claim that HGH triggers HUGE muscle growth? I was under the
    impression that only steroids did that.

    Most of the sites referenced by google were either to anabolics
    producers or bodybuilding websites, but there were more credible ones too.
    HGH is, btw, a steroid. I was under the (apparently mistaken)
    impression that it acted mostly as a glucocorticoid, since it has
    well-known diabetic effects, but it's GROWTH hormone--and growth is, uh,
    anabolic. See:

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8408471&dopt=Abstract

    --
    Mark & Steven Bornfeld DDS
    http://www.dentaltwins.com
    Brooklyn, NY
    718-258-5001

  9. PedalChick said:

    Can someone please provide a scientific reference that backs up the
    claim that HGH triggers HUGE muscle growth? I was under the
    impression that only steroids did that.

    Stop asking such awkward questions, you might ruin the party.

    [censored].

  10. "Mark & Steven Bornfeld DDS" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:
    PedalChick said:

    "B. Lafferty" <[email hidden]> wrote in message


    news:<[email hidden]>...

    Quoted message said:
    Quoted message said:


    Quoted message said:

    Interesting article from the Guardian.
    IOC 'four years late' catching cheats

    Duncan Mackay - Athletics Correspondent
    Sunday August 8, 2004

    The Observer

    Olympics chiefs could have introduced a test for the most widely abused


    drug

    Quoted message said:
    Quoted message said:
    Quoted message said:

    in sport four years ago, but instead allowed athletes to continue using


    it

    Quoted message said:
    Quoted message said:
    Quoted message said:

    without fear of detection, according to a leading British scientist.
    Professor Peter Sonksen, who did much of the work on trying to find ways


    to

    Quoted message said:
    Quoted message said:
    Quoted message said:

    catch athletes using human growth hormone - known as 'the drug of


    champions'

    Quoted message said:
    Quoted message said:
    Quoted message said:

    and particularly popular among sprinters - says the International


    Olympic

    Quoted message said:
    Quoted message said:
    Quoted message said:

    Committee shied away from taking a hard-line stance 'for political


    reasons'.

    Quoted message said:
    Quoted message said:
    Quoted message said:


    Human growth hormone (HGH) can trigger huge increases in muscle growth


    and

    Quoted message said:
    Quoted message said:
    Quoted message said:

    has been around for about 20 years. While it has been widely used by
    athletes in several sports, officials have struggled to come up with a


    test

    Quoted message said:
    Quoted message said:
    Quoted message said:

    for it.

    Can someone please provide a scientific reference that backs up the
    claim that HGH triggers HUGE muscle growth? I was under the
    impression that only steroids did that.

    Most of the sites referenced by google were either to anabolics
    producers or bodybuilding websites, but there were more credible ones too.
    HGH is, btw, a steroid. I was under the (apparently mistaken)
    impression that it acted mostly as a glucocorticoid, since it has
    well-known diabetic effects, but it's GROWTH hormone--and growth is, uh,
    anabolic. See:


    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8408471&dopt=Abstract

    Quoted message said:


    --


    It's not a steroid, it's a large protein. Why is it so hard for folks to
    refrain from posting things they don't truly know anything about? It only
    adds to someone else thinking they have learned the facts.
    -Mike

  11. Mike Owens said:

    It's not a steroid, it's a large protein. Why is it so hard for folks to
    refrain from posting things they don't truly know anything about? It only
    adds to someone else thinking they have learned the facts.
    -Mike

    but it is a hormone. and vitamin d is a steroid. a square is also a
    type of rectangle.

  12. "gym gravity" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:
    Mike Owens said:

    It's not a steroid, it's a large protein. Why is it so hard for folks


    to

    Quoted message said:
    Quoted message said:

    refrain from posting things they don't truly know anything about? It


    only

    Quoted message said:
    Quoted message said:

    adds to someone else thinking they have learned the facts.
    -Mike

    but it is a hormone. and vitamin d is a steroid. a square is also a
    type of rectangle.


    Vitamin D is not a steroid in the classic sense that is the subject of
    doping in sports. Those would be the adrenal, testicular and ovarian
    steroids. The only commonality between vitamin D and "sports" steroids is
    that the original precursor is cholesterol.

    There are many, indeed most, hormones that are not steroids or even
    steroid-like. Hormones, by the definition I used when I taught molecular
    endocrinology to medical residents, were any substance produced by the body
    that conveyed information to other parts of the body. This is a huge group
    of compounds and conveys little useful information. The term "steroid" is
    much more specific. Nice thing about science is that there are specific
    words available to concisely describe what you want.

    A square is a type of rectangle and a BigWheel is a type of pedal-powered
    vehicle. Will Bettini win a gold on a BigWheel?
    -Mike

  13. Mike Owens said:

    "gym gravity" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:
    Mike Owens said:


    It's not a steroid, it's a large protein. Why is it so hard for folks

    to

    Quoted message said:
    Quoted message said:

    refrain from posting things they don't truly know anything about? It

    only

    Quoted message said:
    Quoted message said:

    adds to someone else thinking they have learned the facts.
    -Mike

    but it is a hormone. and vitamin d is a steroid. a square is also a
    type of rectangle.

    Vitamin D is not a steroid in the classic sense that is the subject of
    doping in sports. Those would be the adrenal, testicular and ovarian
    steroids. The only commonality between vitamin D and "sports" steroids is
    that the original precursor is cholesterol.

    There are many, indeed most, hormones that are not steroids or even
    steroid-like. Hormones, by the definition I used when I taught molecular
    endocrinology to medical residents, were any substance produced by the body
    that conveyed information to other parts of the body. This is a huge group
    of compounds and conveys little useful information. The term "steroid" is
    much more specific. Nice thing about science is that there are specific
    words available to concisely describe what you want.

    but the way you are using "steroid" still isn't as specific as you think
    you are using it. You chose to define steroid by it's classical sense
    (as an anabolic?) in one paragraph and by it's biochemical precursers in
    another, why not slap another level on it and define it by its mode of
    action (as a nuclear hormone)?

    A steroid is a type of hormone. Bettini, if he wins, will do so riding
    a bike with wheels that are bigger than a Big Wheel's wheels. But
    Vinokourov will win.

  14. "gym gravity" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:
    Mike Owens said:

    "gym gravity" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    Mike Owens wrote:

    >
    >It's not a steroid, it's a large protein. Why is it so hard for folks

    to

    Quoted message said:

    >refrain from posting things they don't truly know anything about? It

    only

    Quoted message said:

    >adds to someone else thinking they have learned the facts.
    >-Mike
    >
    >

    but it is a hormone. and vitamin d is a steroid. a square is also a
    type of rectangle.

    Vitamin D is not a steroid in the classic sense that is the subject of
    doping in sports. Those would be the adrenal, testicular and ovarian
    steroids. The only commonality between vitamin D and "sports" steroids


    is

    Quoted message said:
    Quoted message said:

    that the original precursor is cholesterol.

    There are many, indeed most, hormones that are not steroids or even
    steroid-like. Hormones, by the definition I used when I taught


    molecular

    Quoted message said:
    Quoted message said:

    endocrinology to medical residents, were any substance produced by the


    body

    Quoted message said:
    Quoted message said:

    that conveyed information to other parts of the body. This is a huge


    group

    Quoted message said:
    Quoted message said:

    of compounds and conveys little useful information. The term "steroid"


    is

    Quoted message said:
    Quoted message said:

    much more specific. Nice thing about science is that there are specific
    words available to concisely describe what you want.

    but the way you are using "steroid" still isn't as specific as you think
    you are using it. You chose to define steroid by it's classical sense
    (as an anabolic?) in one paragraph and by it's biochemical precursers in
    another, why not slap another level on it and define it by its mode of
    action (as a nuclear hormone)?


    I am defining "steroid" by its chemical definition - compound that contains
    a specific 4 ringed heterocyclic system with a specific numbering system for
    each of the carbon atoms. It doesn't get any more specific than that.
    Steroids are not all analabolic; many are catabolic (tissue breakdown) such
    as the glucocorticoids which [censored] Voet writes are/were prevalent in the
    peloton. I have no doubt that they can be performancing enhancing in the
    short term (1. reduced microinflammation and consequently reduced
    production of certain cytokines that are instrumental in producing what is
    termed "sickness behavior" which is a feeling of general listlissness
    associated with infection, for example; 2. in many, but not all,
    individuals a brain-mediated feeling of well being or perception of feeling
    well/healthy/strong; and 3) increased glucose mobilization).

    Quoted message said:

    A steroid is a

    "very specific"
    -Mike

    type of hormone. Bettini, if he wins, will do so riding

    Quoted message said:

    a bike with wheels that are bigger than a Big Wheel's wheels. But
    Vinokourov will win.

  15. Mike Owens said:

    "gym gravity" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:
    Mike Owens said:

    It's not a steroid, it's a large protein. Why is it so hard for
    folks to refrain from posting things they don't truly know anything
    about? It only adds to someone else thinking they have learned the
    facts. -Mike

    but it is a hormone. and vitamin d is a steroid. a square is also a
    type of rectangle.


    Vitamin D is not a steroid in the classic sense that is the subject of
    doping in sports. Those would be the adrenal, testicular and ovarian
    steroids. The only commonality between vitamin D and "sports"
    steroids is that the original precursor is cholesterol.

    There are many, indeed most, hormones that are not steroids or even
    steroid-like. Hormones, by the definition I used when I taught
    molecular endocrinology to medical residents, were any substance
    produced by the body that conveyed information to other parts of the
    body.


    Great, so now we have medical residents thinking acetylcholine is a hormone.

  16. "Kyle Legate" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:
    Mike Owens said:

    "gym gravity" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    Mike Owens wrote:
    >
    >
    > It's not a steroid, it's a large protein. Why is it so hard for
    > folks to refrain from posting things they don't truly know anything
    > about? It only adds to someone else thinking they have learned the
    > facts. -Mike
    >
    >

    but it is a hormone. and vitamin d is a steroid. a square is also a
    type of rectangle.


    Vitamin D is not a steroid in the classic sense that is the subject of
    doping in sports. Those would be the adrenal, testicular and ovarian
    steroids. The only commonality between vitamin D and "sports"
    steroids is that the original precursor is cholesterol.

    There are many, indeed most, hormones that are not steroids or even
    steroid-like. Hormones, by the definition I used when I taught
    molecular endocrinology to medical residents, were any substance
    produced by the body that conveyed information to other parts of the
    body.


    Great, so now we have medical residents thinking acetylcholine is a


    hormone.

    Quoted message said:


    In the very broadest sense, that's accurate. However, anyone of reason and
    not looking to pick a fight (plus all the medical residents I interacted
    with) understand that "convey information to other parts of the body" means
    somewhat farther away than the 20-30 nm of a synaptic cleft.
    -Mike

  17. "Mike Owens" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:


    "Kyle Legate" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:
    Mike Owens said:

    "gym gravity" <[email hidden]> wrote in message
    news:[email hidden]...
    > Mike Owens wrote:
    >>
    >>
    >> It's not a steroid, it's a large protein. Why is it so hard for
    >> folks to refrain from posting things they don't truly know anything
    >> about? It only adds to someone else thinking they have learned the
    >> facts. -Mike
    >>
    >>
    >
    > but it is a hormone. and vitamin d is a steroid. a square is also a
    > type of rectangle.
    Vitamin D is not a steroid in the classic sense that is the subject of
    doping in sports. Those would be the adrenal, testicular and ovarian
    steroids. The only commonality between vitamin D and "sports"
    steroids is that the original precursor is cholesterol.

    There are many, indeed most, hormones that are not steroids or even
    steroid-like. Hormones, by the definition I used when I taught
    molecular endocrinology to medical residents, were any substance
    produced by the body that conveyed information to other parts of the
    body.


    Great, so now we have medical residents thinking acetylcholine is a


    hormone.

    Quoted message said:


    In the very broadest sense, that's accurate. However, anyone of reason


    and

    Quoted message said:

    not looking to pick a fight (plus all the medical residents I interacted
    with) understand that "convey information to other parts of the body"


    means

    Quoted message said:

    somewhat farther away than the 20-30 nm of a synaptic cleft.
    -Mike


    Fine then. Interferon, how's that? Not a hormone, yet fits your definition.
    Are you teaching your residents that if they have to give interferon alpha
    to a cancer patient they're injecting a hormone?

  18. "Kyle Legate" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:


    "Mike Owens" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:


    "Kyle Legate" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    Mike Owens wrote:
    > "gym gravity" <[email hidden]> wrote in message
    > news:[email hidden]...
    >> Mike Owens wrote:
    >>>
    >>>
    >>> It's not a steroid, it's a large protein. Why is it so hard for
    >>> folks to refrain from posting things they don't truly know


    anything

    Quoted message said:
    Quoted message said:
    Quoted message said:

    >>> about? It only adds to someone else thinking they have learned


    the

    Quoted message said:
    Quoted message said:
    Quoted message said:

    >>> facts. -Mike
    >>>
    >>>
    >>
    >> but it is a hormone. and vitamin d is a steroid. a square is also


    a

    Quoted message said:
    Quoted message said:
    Quoted message said:

    >> type of rectangle.
    > Vitamin D is not a steroid in the classic sense that is the subject


    of

    Quoted message said:
    Quoted message said:
    Quoted message said:

    > doping in sports. Those would be the adrenal, testicular and


    ovarian

    Quoted message said:
    Quoted message said:
    Quoted message said:

    > steroids. The only commonality between vitamin D and "sports"
    > steroids is that the original precursor is cholesterol.
    >
    > There are many, indeed most, hormones that are not steroids or even
    > steroid-like. Hormones, by the definition I used when I taught
    > molecular endocrinology to medical residents, were any substance
    > produced by the body that conveyed information to other parts of the
    > body.
    >
    Great, so now we have medical residents thinking acetylcholine is a


    hormone.

    Quoted message said:


    In the very broadest sense, that's accurate. However, anyone of reason


    and

    Quoted message said:

    not looking to pick a fight (plus all the medical residents I interacted
    with) understand that "convey information to other parts of the body"


    means

    Quoted message said:

    somewhat farther away than the 20-30 nm of a synaptic cleft.
    -Mike


    Fine then. Interferon, how's that? Not a hormone, yet fits your


    definition.

    Quoted message said:

    Are you teaching your residents that if they have to give interferon alpha
    to a cancer patient they're injecting a hormone?


    Jeez, I thought this was dead. The classic definition was that hormones
    were produced by tissues of the endocrine system. The endocrine, nervous
    and immune systems comprised three systems which released chemical mediators
    that could communicate information to other parts of the body. Under this
    old system, interferon would not be a hormone (because it came from the
    immune system and not the endocrine system). Happy? I can understand that
    you may have been taught this definition in some survey course you took.
    However, as stated on page 1 of Williams Textbook of Endocrinology, 9th
    edition, 1998, "The traditional definition of endocrinology has become even
    more blurred....". This is because all three systems are regulated by and
    can regulate each other. My more recent 10th edition at home probably
    talks about things being blurrier now. I have no qualms about my definition
    of hormone to the residents and fellows.

    If you can remember back, the idea is for RBR readers to know that all
    steroids are hormones, only some hormones are steroids.
    -Mike

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