I use slime on my ancient cyclo-cross and a 29er. It is good get you home, back to the pits stuff, but not a total fix. I still have to fix the punctures, but get to decide pretty much when. Tried it in a roadie, but not found it so useful on high pressure/low volume tires.
The only reason I use it on those two bikes is that Dutch Perfect don't make a suitable tire to fit them. Which is what I use on my usual commuter bike. Now if you dislike flats, that is a tire to try.
A fun experience I've had, twice (touch wood) with slime is that I've gone pulled the tube, pumped it up a little to see where the punctures are, and the tube has split showering green goo everywhere. I put that down to my punctures generally being cuts from broken glass on the cycle path, or flint shards in the hard-pack, rather than the pierced holes a thorn or tack might make. Oh, and pumping the tube up too far to see where the holes are (generally more than one). Doh!
The tubes I use it on have a Woods valve, also used it on a Schrader, which was fiddly. Never done it to a Presta, it is supposed to be possible from instructions I've read, but looks like a recipe for green goo everywhere. Yet might try it, the proper way, as I've just purchased some new tubes for my MTB racer that have removable valve cores.