glutathione supplement

michel martin said:

i need more informations about GSH supplementation.

In the link discution (http://yarchive.net/med/glutathione.html) it's said
that extracellular glutathione is not needed and to increase it by
supplementation is waste of money.

i've found others article which explain the opposite:
http://members.tripod.com/uvicf/gsh/layman_gsh.htm

Anyone can give more info about GSH intestinal absorption?
Is liposomal GSH really effective?

Because of the absorption controversy, I prefer to take glutathione
precursors. Among these, N-Acetyl-Cysteine appears to be the most
important one. I take roughly 2g/day of NAC together with 4g of Vit. C
as recommended by LEF: http://www.lef.org/newshop/items/item00215.html

michel martin said:

hello

i need more informations about GSH supplementation.

In the link discution (http://yarchive.net/med/glutathione.html) it's said
that extracellular glutathione is not needed and to increase it by
supplementation is waste of money.

i've found others article which explain the opposite:
http://members.tripod.com/uvicf/gsh/layman_gsh.htm

Anyone can give more info about GSH intestinal absorption?
Is liposomal GSH really effective?

cyril

The best way to increase your glutathione levels is by eating Sulfur
rich foods: eggs (among the best sources of sulfur), whole cow's milk,
meats, cheese, broccoli, cauliflower, kale, brussel sprouts, watercress,
radish, leek, horseradish, mustard leaves, onion, and garlic.

--
Dawid Michalczyk
http://www.art.eonworks.com - Art and Illustration

Free Radic Biol Med. 2004 Oct 1;37(7):953-60. Related Articles, Links

Progressive iron accumulation induces a biphasic change in the
glutathione content of neuroblastoma cells.

Nunez MT, Gallardo V, Munoz P, Tapia V, Esparza A, Salazar J, Speisky
H.

Department of Biology, Faculty of Sciences, Universidad de Chile,
Santiago, Chile.

Glutathione (GSH) constitutes the single most important antioxidant in
neurons, whereas iron causes oxidative stress that leads to cell damage
and death. Although GSH and iron produce opposite effects on redox cell
status, no mechanistic relationships between iron and GSH metabolism
are known. In this work, we evaluated in SH-SY5Y neuroblastoma cells
the effects of iron accumulation on intracellular GSH metabolism. After
2 d exposure to increasing concentrations of iron, cells underwent
concentration-dependent iron accumulation and a biphasic change in
intracellular GSH levels. Increasing iron from 1 to 5 microM resulted
in a marked increase in intracellular oxidative stress and increased
GSH levels. Increased GSH levels were due to increased synthesis.
Further increases in iron concentration led to significant reduction in
both reduced (GSH) and total (GSH + (2 x GSSG)) glutathione. Cell
exposure to high iron concentrations (20-80 microM) was associated with
a marked decrease in the GSH/GSSG molar ratio and the GSH half-cell
reduction potential. Moreover, increasing iron from 40 to 80 microM
resulted in loss of cell viability. Iron loading did not change GSH
reductase activity but induced significant increases in GSH peroxidase
and GSH transferase activities. The changes in GSH homeostasis reported
here recapitulate several of those observed in Parkinson's disease
substantia nigra. These results support a model by which progressive
iron accumulation leads to a progressive decrease in GSH content and
cell reduction potential, which finally results in impaired cell
integrity.

PMID: 15336311 [PubMed - in process]

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Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

Glutathione raised by phlebotomy / bloodletting ..

Could it be somehow linked to .. erythropoietin .. ?

Comp Biochem Physiol B. 1983;75(1):5-8. Related Articles, Links

Effect of experimental anaemia on red cell GSH and enzyme activities in
guinea-pig and rabbit.

Suzuki M, Kataoka T.

1. The effect of experimental anaemia on red cell GSH and enzyme
activities of GSH-Px, GSSG-R and G6PD was investigated in guinea-pig
and rabbit. 2. The anaemia was induced by injection of PHH in
guinea-pig and rabbit and also by bleeding in guinea-pig. 3. Red cell
GSH increased from 115.5 to 141.8 mg/dl RBC in the guinea-pig and from
108.5 to 133.5 mg/dl RBC in the rabbit during anaemia. 4. There were
significant rises in the level of all the three enzymes activities in
both the species of animals. However, the changes in rabbit were more
pronounced than in the guinea-pig.

PMID: 6851486 [PubMed - indexed for MEDLINE]

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1: Aust J Biol Sci. 1975 Jun;28(3):233-8. Related Articles, Links

The effect of experimental anaemia on the levels of glutathione and
glycolytic enzymes of the erythrocytes of normal and
glutathione-deficient Merino sheep.

Agar NS, Roberts J, Mulley A, Board PG, Harley JD.

The effects of experimental anaemia on the levels of reduced
glutathione (GSH) and the activity of glycolytic enzymes in the
erythrocytes of normal and GSH-deficient Merino sheep were
investigated. There was a rise in red cell GSH levels in both groups of
sheep; the magnitude of this response was, however, quite different.
When expressed as a percentage of the initial value, the rise in GSH
level was 18% in normal and 263% in GSH-deficient animals. There was
also an increase in the activities of various enzymes following
phlebotomy but this increase was similar in the two groups of sheep.

PMID: 126681 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

"Glutathione raised by phlebotomy / bloodletting ..

Could it be somehow linked to .. erythropoietin .. ?"

No, in science when our notions fail we turn from them to find the truth.
If you want to increase it, eat whey.

A good example of the min, opt, max process. An increase in iron
increased glutathione, a max dose was rlated to a lowering of it. Biology
is not a black or white thing, the whole picture must be considered not
bits and pieces of non related posting of abstracts not comprehended in
the first instance.