Glucosamine

matty said:

What is the recommended 'dosage' for Glucosamine, if
taken for knee problems, anyone know?1000mg a day,
or more?
TIA
matty

I had a bottle of Nature Made Triple Flex Triple Strength supplement
which recommended two caplets per day. Two caplets provided 1500 mg of
Glucosamine Hydrochloride, 1200 mg of Chondroitin Sulfate, and 250 mg
of Methylsulfonylmethane (MSM) none of which has an established daily
value.

The bottle boasts that the product promotes healthy joint function,
comfort, flexibility, and mobility, however on the very same label it
also offers the lament: "These statements have not been evaluated by
the Food and Drug Administration. This product is not intended to
dianose, treat, cure or prevent any disease."

Hnh.

--
Curt
http://curtjames.com/

In article <[email hidden]>,

matty said:

What is the recommended 'dosage' for Glucosamine, if taken for knee
problems, anyone know?1000mg a day, or more?
TIA
matty

1,000 mg. per day per 50 lbs. of body weight.
--
Om.

"My mother never saw the irony in calling me a son-of-a-[censored]." -Jack Nicholson

OmManiPadmeOmelet said:

matty said:

What is the recommended 'dosage' for Glucosamine, if taken for knee
problems, anyone know?1000mg a day, or more?

1,000 mg. per day per 50 lbs. of body weight.

Glucosamine is 40 time more potent than sugar in promoting insulin
resistance. There have been clinical studies, but the issue of whether
even common long term dosages are dangerous is not yet settled:

http://www.clinicaltrials.gov/ct/show/NCT00065377

I think it would be wise to determine the smallest amount that works
and not be too liberal with the dosage.

Quoted message said:

1,000 mg. per day per 50 lbs. of body weight.

Gee that sounds a lot! I weigh 185 lbs, so that's almost 4000mg!

Quoted message said:

I think it would be wise to determine the smallest amount that works
and not be too liberal with the dosage.

Problem there being it doesn't 'work' for everyone, so if I don't feel any
effect is it because it doesn't work for me, or because I'm not taking
enough (or both)!
matty

matty said:

Quoted message said:

I think it would be wise to determine the smallest amount that works
and not be too liberal with the dosage.

Problem there being it doesn't 'work' for everyone, so if I don't
feel any effect is it because it doesn't work for me, or because I'm
not taking enough (or both)!

Well, I'm just pointing out one needs to be cautious.

It's been suggested to try and find a dose that works and then
gradually decrease. It wouldn't be as easy to do as with vit C
obviously (re Cohen' rule for colds: find the dosage of C that makes
you run to the toilet and subtract 0.5g).

"Glucosamine is 40 time more potent than sugar in promoting
insulin resistance. There have been clinical studies, but the
issue of whether even common long term dosages are
dangerous is not yet settled: "
The study you quoted just says they are going to test
for any effect. unless you also read the results, you are
just making this conclusion up. much like those that take
anecdotal placebo effects and build a case FOR the usage
of glucosamine.

there are known drawbacks relating to blood pressure. there
also are some indications that it might help some problems.
to say it helps "knee pain" is ludicrous. and to recommend
it in high doses to a stranger without doing a medical
examination first is worse.
....thehick

"DZ" <[email hidden]> wrote

Quoted message said:

matty said:

Quoted message said:

I think it would be wise to determine the smallest amount that works
and not be too liberal with the dosage.

Problem there being it doesn't 'work' for everyone, so if I don't
feel any effect is it because it doesn't work for me, or because I'm
not taking enough (or both)!

Well, I'm just pointing out one needs to be cautious.

It's been suggested to try and find a dose that works and then
gradually decrease. It wouldn't be as easy to do as with vit C
obviously (re Cohen' rule for colds: find the dosage of C that makes
you run to the toilet and subtract 0.5g).

Unless you LIKE the [censored]. Some people do. Kinky, huh? Go figure.

David

thehick said:

Quoted message said:

"Glucosamine is 40 time more potent than sugar in promoting insulin
resistance. There have been clinical studies, but the issue of
whether even common long term dosages are dangerous is not yet
settled: "

The study you quoted just says they are going to test
for any effect.

I didn't quote the study in support of that statement.

Quoted message said:

unless you also read the results, you are just making this
conclusion up.

Unless there is some other possibility, like, for example, that there
is more on glucosamine than just one study. Try this -

http://tinyurl.com/7srkm

"glucosamine is at least 40 times more potent than glucose in
mediating desensitization"

Quoted message said:

much like those that take anecdotal placebo effects and build a case
FOR the usage of glucosamine.

Yes, I'm exactly much like those.

Now that we're clear on that, one mechanism promoting resistance is
through glucose or glucosamine entering the hexosamine pathway. Only
1-3% of glucose does that, but nearly all glucosamine, by bypassing
the key enzyme GFAT regulating the pathway. People taking glucosamine
in dosages commonly used for supplementation don't show signs of
development of insulin resistance and diabetes. But these studies
aren't long enough. It could be that people supplementing with
glucosamine are substantially increasing their risk of diabetes some
years from now.

DZ said:

matty said:

Quoted message said:

I think it would be wise to determine the smallest amount

that

Quoted message said:

Quoted message said:

Quoted message said:

works and not be too liberal with the dosage.

Problem there being it doesn't 'work' for everyone, so if I

don't

Quoted message said:

Quoted message said:

feel any effect is it because it doesn't work for me, or

because

Quoted message said:

Quoted message said:

I'm not taking enough (or both)!

Well, I'm just pointing out one needs to be cautious.

It's been suggested to try and find a dose that works and then
gradually decrease. It wouldn't be as easy to do as with vit C
obviously (re Cohen' rule for colds: find the dosage of C that

makes

Quoted message said:

you run to the toilet and subtract 0.5g).

Cohen's 'rule for colds' is absolute bull [censored]. Mega-doses of
vitamin c will do nothing for a cold. And I was starting to
think you knew what you were talking about....oooops. 🙂

I read his posts if I'm looking for a good laugh.

locker

locker said:

DZ said:

matty said:

> I think it would be wise to determine the smallest amount

that

Quoted message said:

Quoted message said:

> works and not be too liberal with the dosage.

Problem there being it doesn't 'work' for everyone, so if I

don't

Quoted message said:

Quoted message said:

feel any effect is it because it doesn't work for me, or

because

Quoted message said:

Quoted message said:

I'm not taking enough (or both)!

Well, I'm just pointing out one needs to be cautious.

It's been suggested to try and find a dose that works and then
gradually decrease. It wouldn't be as easy to do as with vit C
obviously (re Cohen' rule for colds: find the dosage of C that

makes

Quoted message said:

you run to the toilet and subtract 0.5g).

Cohen's 'rule for colds' is absolute bull [censored].

Your doubt of me hurts tremendously. You have hurt my feelings on New
Years Eve 🙁

Quoted message said:

Mega-doses of
vitamin c will do nothing for a cold. And I was starting to
think you knew what you were talking about....oooops. 🙂

No, no, really, I would prefer you not take any of my advice. Sump
pumps the shallow end of the gene pool.

Quoted message said:

I read his posts if I'm looking for a good laugh.

Instead of flinging your [censored] on the other "special" kids on the short
school bus? I'm glad I can make your otherwise dreary life a little
happier.

David

"matty" <[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

Quoted message said:

1,000 mg. per day per 50 lbs. of body weight.

Gee that sounds a lot! I weigh 185 lbs, so that's almost 4000mg!

Quoted message said:

I think it would be wise to determine the smallest amount that works
and not be too liberal with the dosage.

Problem there being it doesn't 'work' for everyone, so if I don't feel any
effect is it because it doesn't work for me, or because I'm not taking
enough (or both)!
matty

Studies support that statement for example, Glucoamine hydrochloride has
been shown to be no more effective than a placebo in relieving
osteoarthritis signs and symptoms...1998 study at Mount Sinai Hospital.

Glucoamine that has worked in clinical studies has been bound to sodium
(that is the ONLY patented form of Glucoamine in the world) the other form
of GS is bound to potassium I can say from clinical experience that it
appears to work. Chrondroitin forget it, it works to made the company
marketing and selling it money but unless you are in the equine or live
stock family the molecule is simply to large for humans to absorb. The
studies that showed a benifit from the use of chrondroitin it is believed to
be from the sulfur molecule not the chrondroitin.