They find genetic iron mutations COMMON in those with gestational
diabetes .. AND .. find iron is ALWAYS .. higher ..
<<snip>>
serum ferritin levels were increased in patients with GDM compared to
healthy pregnant controls
<<snip>>
Fetal Diagn Ther. 2005 Sep-Oct;20(5):349-54. Related Articles, Links
Increased C282Y Heterozygosity in Gestational Diabetes.
Cauza E, Hanusch-Enserer U, Bischof M, Spak M, Kostner K, Tammaa A,
Dunky A, Ferenci P.
Department of Internal Medicine V, Department of Diabetes, Metabolism
and Rheumatology, Wilhelminenspital, Vienna, Austria.
Background: Hereditary hemochromatosis is an autosomal recessive
disorder of iron metabolism that is characterized by excess
accumulation of iron in various organs and often leads to diabetes
mellitus (DM). To study whether mutations in the hemochromatosis gene
(HFE) could be a risk factor for the development of gestational
diabetes mellitus (GDM), the prevalence of HFE mutations in patients
with GDM was compared to that of healthy pregnant controls. Methods:
GDM was diagnosed in 208 of 2,421 pregnant woman screened between the
24th and 28thweek of gestation over a period of 18 months. Patients and
170 matched control subjects were screened for the HFE gene mutations
C282Y and H63D. Results: In North and Central European GDM patients,
the allele frequency of the C282Y mutation (7.7%) was higher than in
pregnant controls (2.9%; p = 0.04), while the frequency of the H63D
mutation was not different (p = 0.45). Three patients with GDM were
homozygous for H63D (3.1%), 1 patient was homozygous for C282Y (1.0%),
2 patients were compound heterozygous (2.0%) and 26 were heterozygous
[11 C282Y (11.2%) and 15 H63D (15.3%)]. C282Y and H63D allele
frequencies were not different between controls and GDM patients of
Southern European or non-European origin. Irrespective of the
HFE-mutation status, serum ferritin levels were increased in patients
with GDM compared to healthy pregnant controls (p = 0.01), while
transferrin saturation was similar in both groups. Conclusions: In
North and Central European patients with GDM, the C282Y allele
frequency is higher than in healthy pregnant women, suggesting a
genetic susceptibility to the development of GDM. Copyright (c) 2005 S.
Karger AG, Basel.
PMID: 16113552 [PubMed - in process]
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