"Andy Coggan" <[email hidden]> wrote in message
news:[email hidden]...
Quoted message said:Quoted message said:But don't you get it: nobody knows! All we know is that at least some
people
secrete compound(s) that co-migrate with exogenous EPO, meaning that the
basic premise of the test - i.e., that using electrophoresis you can
differentiate exogenous EPO from other substances - is apparently flawed.
Yet, individuals like you and [censored] Pound are ready to lock people up and
throw away the key.
Apparently quite a few people "get it." That's why Dr. de Ceaurriz used
three methodologies in testing for EPO. Only if ALL three methodologies
came up positive did they consider it a positive finding for EPO. Care to
address yourself to the other two methodologies used? I'm certain Dr. de
Ceaurriz would be most interested in your thoughts. Perhaps this is why Dr.
Ayotte stated clearly that if Dr. de Ceaurriz said he found EPO in the
samples tested, she had no doubt that he did.
Quoted message said:
Quoted message said:Quoted message said:>>> Feel free to consult with your buddy Eddie the Apologist Coyle before
>>> responding.
>>
>> ??
>
> You know who your past co-author is.
Indeed I do - but I don't see how he'd qualify as an apologist for
Armstrong.
The apologia he recently published hypothesizing increased efficiency
created by undocumented (either by biopsy or published human studies)
muscle transformation in Armstrong . But now that Armstrong's urine has
been found to have EPO in it, Eddie will have to consider revising his
findings. Maybe you could help him.
The increase in efficiency wasn't hypothesized, it was measured.
The increased effeciency was not hypothesized, the reason for it was as
stated above
Quoted message said:Moreover, there are plenty of published data to support the hypothesis that
fiber type transformation is possible in voluntarily-training humans, i.e.,
athletes.
Really? It is beleived that training can convert Type IIA muscle fibers
into Type IIB fibers. There was one study showing that conversion of Type
II to Type I can occur in rats, but no study demonstrating that training
effect in humans. As Coyle states, "To our knowledge, there have been no
longitudinal studies performed over years on humans directly testing the
hypothesis that type II fibers can be converted to type I muscle fibers with
continued intense endurance training. However, during periods of extreme
endurance training of rats, skeletal muscle appears to display conversion of
type II to type I fibers (18). [ 18. Green H, Klug G, Reichmann H, Seedorf
U, Wiehrer W, and Pette D. Exercise-induced fibre type transitions with
regard to myosin, parvalbumin, and sarcoplasmic reticulum in muscles of the
rat. Pflügers Arch 400: 432-438, 1984.[CrossRef][ISI][Medline]]
Of course a muscle biopsy would tell us the answer to Coyles hypothesis but
for whatever reason, Coyle did not or could not have a biopsy taken.
In so far as eaplaining the increased oxygenation needed to support this
increased efficiency, Coyle states, "Other factors that have been reported
to increase cycling efficiency and running economy are intermittent exposure
to hypoxia for several weeks as encountered by athletes who spend periods
living at high altitude or in hypoxic environments (19, 30). Like many
endurance athletes, this individual has incorporated hypoxic exposure into
his annual plan, which may be another factor contributing to improved
cycling efficiency." Now we can add the use of EPO to Eddie's list.
Quoted message said:There are also plenty of data linking changes in fiber type to changes in
efficiency.
Type II A to Type II B. See above.
Quoted message said:So, while Coyle didn't obtain muscle tissue from Armstrong to verify that
his fiber type had changed over the years, it's a plausible hypothesis to
explain the measured changes in efficiency.
Six positive samples for EPO more than explains the increase in efficiency.
Quoted message said:
Of course, I don't have the foggiest idea what this might have to do with
alleged use of EPO, since Armstrong stopped visiting Coyle's lab prior to
his first TdF victory...
Interesting. I guess his conversation with Lemond as reported in the Walsh
book got him thinking and hypothesizing. Lovely.
Quoted message said:
Andy Coggan
