Nutrition. 2004 Apr;20(4):368-71. Related Articles, Links
Efficacy of long-term dietary restriction of total
calories, fat, iron, and protein in patients with chronic
hepatitis C virus.
Iwasa M, Iwata K, Kaito M, Ikoma J, Yamamoto M, Takeo M,
Kuroda M, Fujita N, Kobayashi Y, Adachi Y.
Third Department of Internal Medicine, Mie University School
of Medicine, Tsu, Japan.
OBJECTIVES: A diet restrictive in total calories, fat, iron,
and protein intake reduces serum alanine aminotransferase
levels in patients with long-term hepatitis C virus
infection. However, whether long-term dietary therapy causes
adverse effects such as malnutrition and anemia due to a
shortage of energy intake is not clear. We evaluated the
balance of energy intake and changes in physical and
hematologic indices of nutrition after a long-term dietary
therapy. METHODS: Twenty-two patients with long-term
hepatitis C virus infection that did not respond to or who
were able or unwilling to take interferon therapy were
enrolled in this study. Our prescriptions included 7
mg/d or less of iron, 30 kcal. kg(-1). d(-1) of energy, 1.1
to 1.2 g. kg(-1). d(-1) of protein, and a fat energy
fraction of 20%. Patients were followed for 24 mo.
RESULTS: Mean body fat percentage was 24.6% at entry and
was significantly reduced after the diet prescription.
Mean serum ferritin decreased significantly from 376
ng/mL at entry to 141 ng/mL after 24 mo. Mean serum
alanine aminotransferase levels decreased significantly
from 66 to 49
mg/A. Mean levels of hemoglobin, serum albumin, and
cholinesterase did not change significantly during the
follow-up period. CONCLUSIONS: These results suggest
that restriction of energy, fat, iron, and protein
intakes is safely tolerated, so its long-term use
should be recommended to patients with long-term
infection with hepatitis C virus.
PMID: 15043853 [PubMed - in process]
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