"Mr-Natural-Health" <[email hidden]> wrote in
message news:[email hidden]...
Quoted message said:
Eric said:1) Am I losing any nutritional value by drinking the decaf kind?
Caffeine is just plain bad for you. Besides causing insomnia and
withdrawal headaches, caffeine raises your blood pressure and
homocysteine levels.
Virology. 2005 May 10;335(2):177-84. Related Articles, Books, LinkOut
Inhibition of HIV-1 replication by caffeine and caffeine-related
methylxanthines.
Nunnari G, Argyris E, Fang J, Mehlman KE, Pomerantz RJ, Daniel R.
The Dorrance H. Hamilton Laboratories, Center for Human Virology and
Biodefense, Division of Infectious Diseases and Environmental Medicine,
Department of Medicine, Jefferson Medical College, Thomas Jefferson
University, Philadelphia, PA 19107, USA.
Human immunodeficiency virus type I (HIV-1) DNA integration is an essential
step of viral replication. We have suggested recently that this stage of
HIV-1 life-cycle triggers a cellular DNA damage response and requires
cellular DNA repair proteins for its completion. These include DNA-PK
(DNA-dependent protein kinase), ATR (ataxia telangiectasia and
Rad3-related), and, at least in some circumstances, ATM (ataxia
telangiectasia mutated). Host cell proteins may constitute an attractive
target for anti-HIV-1 therapeutics, since development of drug resistance
against compounds targeting these cellular cofactor proteins is unlikely. In
this study, we show that an inhibitor of ATR and ATM kinases, caffeine, can
suppress replication of infectious HIV-1 strains, and provide evidence that
caffeine exerts its inhibitory effect at the integration step of the HIV-1
life-cycle. We also demonstrate that caffeine-related methylxanthines
including the clinically used compound, theophylline, act at the same step
of the HIV-1 life-cycle as caffeine and efficiently inhibit HIV-1
replication in primary human cells. These data reveal the feasibility of
therapeutic approaches targeting host cell proteins and further support the
hypothesis that ATR and ATM proteins are involved in retroviral DNA
integration.
PMID: 15840517 [PubMed - in process]