Pizza Girl. said:Osteoporosis victims are already flooded with calcium from their bones. Do you
really think more will help?
Since you are cross posting to a diabetes newsgroup, you should be aware
that calcium metabolism in diabetics is different from people with
normal glycemia. Type 1 and type 2 diabetic are different from each
other as well. Of course, these sort of things do not matter to trolls.
"The Fracture Intervention Trial
OBJECTIVE—Alendronate sodium (ALN) increases bone mineral density (BMD)
in heterogeneous populations of postmenopausal women, but its effect is
unknown in women with type 2 diabetes. The objective of this project was
to compare changes in BMD during 3 years of ALN treatment versus placebo
in diabetic women.
RESEARCH DESIGN AND METHODS—We used data from the Fracture Intervention
Trial, a randomized blinded placebo-controlled trial conducted at 11
centers in which 6,458 women aged 54–81 years with a femoral neck BMD of
0.68 g/cm2 were randomly assigned to either placebo or 5 mg/day ALN for
2 years, followed by 10 mg/day for the remainder of the trial. BMD was
measured by dual-energy X-ray absorptiometry. Type 2 diabetes (n = 297)
was defined by self-report, use of insulin or other hypoglycemic agents,
or a random nonfasting glucose value 200 mg/dl.
RESULTS—In diabetic women, 3 years of ALN treatment was associated with
increased BMD at all sites studied, including 6.6% at the lumbar spine
and 2.4% at the hip, whereas women in the placebo group experienced a
decrease in BMD at all sites except the lumbar spine. The
safety/tolerability of ALN was similar to placebo, except for abdominal
pain, which was more likely in the ALN group.
CONCLUSIONS—ALN increased BMD relative to placebo in older women with
type 2 diabetes and was generally well tolerated as a treatment for
osteoporosis. Increases in BMD with ALN therapy compared with placebo
were similar between women with and without diabetes.
Abbreviations: ALN, alendronate sodium • BMD, bone mineral density •
BSAP, bone-specific alkaline phosphatase • CTx, COOH-terminal
telopeptide of type I collagen • FIT, Fracture Intervention Trial • NTx,
NH2-terminal propeptide of type I collagen" Source: Alendronate
Increases Bone Mineral Density in Older Diabetic Women
http://care.diabetesjournals.org/cgi/content/abstract/27/7/1547
http://www.medscape.com/viewarticle/482675?src=mp
Cardiovascular Disease and Arterial Calcification in Insulin-Dependent
Diabetes Mellitus: Interrelations and Risk Factor Profiles -
http://atvb.ahajournals.org/cgi/reprint/11/4/958
Similar articles in PubMed - http://tinyurl.com/8qeyg.
Frank
