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antioxidant activity may be an important mechanism of action
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Phytother Res. 2005 Sep 21;19(8):669-673 [Epub ahead of print] Related
Articles, Links
Antioxidant and DNA protecting properties of anti-fatigue herb
Trichopus zeylanicus.
Tharakan B, Dhanasekaran M, Manyam BV.
Department of Neurology, Scott & White Clinic and Memorial Hospital;
Scott, Sherwood and Brindley Foundation, Temple, Texas, USA.
Chronic fatigue is considered a complex symptom for which currently
there is no curative treatment available. Oxidative stress plays an
important role in the etiology of fatigue and antioxidant treatment
might be a valuable therapeutic approach. The Kani, a tribal high
altitude living population in southern India, traditionally use the
seeds of Trichopus zeylanicus to combat fatigue. In this study, the
antioxidant properties of Trichopus zeylanicus were established on free
radicals (DPPH and ABTS), its ability to reduce iron, lipoxygenase
activity and hydrogen peroxide-induced lipid peroxidation. The effects
of Trichopus zeylanicus on reactive oxygen species induced plasmid DNA
(pBR322) cleavage were also investigated. Trichopus zeylanicus
significantly scavenged free radicals, reduced lipid peroxidation and
inhibited lipoxygenase activity. Trichopus zeylanicus also exhibited
iron-chelating activity and inhibited reactive oxygen species induced
DNA damage. Trichopus zeylanicus contains NADH, polyphenols and
sulfhydryl compounds, which have the ability to scavenge reactive
oxygen species suggesting that the antioxidant activity may be an
important mechanism of action of Trichopus zeylanicus to combat
fatigue. Copyright (c) 2005 John Wiley & Sons, Ltd.
PMID: 16177968 [PubMed - as supplied by publisher]
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