Chemo go-faster drugs! Lance, Alberto?

Doctor.House said:

PDM and Sean Kelly overdosed on EPO back in July 1991. We have come a long way since then.

Today EPO is aspirin to top cyclists and triathletes. EPO was old hat when Lance won his first TDF in 1999. Phamrstrong dropped EPO confessed Alex Zulle and Fernado Escartin whist on superior doping protocols and drugs.

Besides cow blood (Actovegin)
and Aranesp (EPO)
and steroids
and insulin
and corticoids

a then, little know research drug by Allos Therapeutics was in the field. RSR-13 recently branded as Efaproxiral. drugs.comrsr13 040504.htmlOpen ↗

Allos Therapeutics is in the chemo enhancement business. But take away the toxic chemo drugs and----step back. Go fast juice.

Roche Pharmaceuticals is rolling out C.E.R.A (more potent, quicker acting EPO) as an Amgen Aranesp dosing alternative.

The anti-anemia marketplace is expeted to grow to $100 BILLION someday---and not just selling into insurance policies for sick people.

The Tour de France will continue to build on its past crimes. Pro cycling is Life Science, nothing more.

Dude I thought you left this forum...

From the article

Quoted post said:

RSR13 (efaproxiral) is the first synthetic small molecule designed to "sensitize" hypoxic (oxygen-deprived) areas of tumors prior to radiation therapy by facilitating the release of oxygen from hemoglobin, the oxygen-carrying protein contained within red blood cells, and increasing the level of oxygen in tumors.

So, how does it work? It says RSR13 facilitates the release of oxygen in tumor cells. Does it work equally well for normal cells? What are the side effects?

Btw. the article is from May 2004. Is there any documented case of RSR13 use as a PED?

Cobblestones said:

From the article

So, how does it work? It says RSR13 facilitates the release of oxygen in tumor cells. Does it work equally well for normal cells? What are the side effects?

Btw. the article is from May 2004. Is there any documented case of RSR13 use as a PED?

Are there any documented athlete cases of:

cow blood?
human growth hormones?
Viagra?
Prozac?

RSR-13 expands 'red blood cells' by 30-50% and thins out (balloons) the membrane wall making; 1) oxygen transfer easier and/or 2) chemo doping more effective.

Thin cell wall = faster acting

Research drugs are secret---hence, you would have no clue what drugs T-Mobile may use next year.

Doctor.House said:

RSR-13 expands 'red blood cells' by 30-50% and thins out (balloons) the membrane wall making; 1) oxygen transfer easier and/or 2) chemo doping more effective.

Thin cell wall = faster acting

Research drugs are secret---hence, you would have no clue what drugs T-Mobile may use next year.

What so instead of increasing the AMOUNT of red blood cells, this stuff actually EXPANDS the effectivness of them? Am i understanding the correctly Dr.House?

So therefore, current dope tests for hematocrit level would be completely useless...?

eep. Also wouldnt thinning the membrane wall be pretty damn dangerous?

Do you think this stuff is widely used my good Doctor?

yeloooooo said:

What so instead of increasing the AMOUNT of red blood cells, this stuff actually EXPANDS the effectivness of them? Am i understanding the correctly Dr.House?

So therefore, current dope tests for hematocrit level would be completely useless...?

eep. Also wouldnt thinning the membrane wall be pretty damn dangerous?

Do you think this stuff is widely used my good Doctor?

Correctimundo my clever friend in yelooo.

Overdosing on any drug can be bad. Prozac to EPO to cortisone,

Widely used? Who can say. Lance and his LAF might know about RSR-13 and Actovegin (Norway cow blood product) too. Too bad we cannot read his Nike board of director minutes.

Maybe Craig Nichols knows?

Maybe a rogue scientist from Allos knows?

You can bet Michele Ferrari knows!

So it thins the membrane of red blood cells. Would that lead to more free hemoglobin in the bloodstream? And if so, could the increased free hemoglobin be picked up by a blood test?

ETA: and you say it expands red blood cells by 30-50%, so could it be tested for by looking at the size of red blood cells under a microscope?

Cobblestones said:

So it thins the membrane of red blood cells. Would that lead to more free hemoglobin in the bloodstream? And if so, could the increased free hemoglobin be picked up by a blood test?

ETA: and you say it expands red blood cells by 30-50%, so could it be tested for by looking at the size of red blood cells under a microscope?

I seriously doubt any WADA lab has any money to spend on blood doping.

They blew their money on Hamilton and Landis w/o much success.

In any case, RSR-13 is in use and has been for many years. Besides the Pharmstrong chemo therapy rumors----the HBOC (aka: allotropic hemoglobin modifier) was discovered by police in the 2001 San Remo Giro Hotel room raids
cyclingnews.comjun12news.shtmlOpen ↗

Emassist (Hemassist) was also found in the athlete rooms. (X-country skiier juice)

The wonderful fraud that is drug cheating is that the fans quickly forget the history, past lies and facts. That's how Bjarne Riis & Lance Armstrong can remain employed.

btw: The RSR-13 June 12, 2001 post followed Jan Ulrich's idiotic quote that all dopers should be suspended for life.

Jan Ulrich, a true doper hypocrite.

Doctor.House said:

I seriously doubt any WADA lab has any money to spend on blood doping.

They blew their money on Hamilton and Landis w/o much success.

In any case, RSR-13 is in use and has been for many years. Besides the Pharmstrong chemo therapy rumors----the HBOC (aka: allotropic hemoglobin modifier) was discovered by police in the 2001 San Remo Giro Hotel room raids
cyclingnews.comjun12news.shtmlOpen ↗

Emassist (Hemassist) was also found in the athlete rooms. (X-country skiier juice)

The wonderful fraud that is drug cheating is that the fans quickly forget the history, past lies and facts. That's how Bjarne Riis & Lance Armstrong can remain employed.

btw: The RSR-13 June 12, 2001 post followed Jan Ulrich's idiotic quote that all dopers should be suspended for life.

Jan Ulrich, a true doper hypocrite.

Thanks for the link, Doctor. That was hilarious. Anyway, I think I have now a better understanding of RSR-13. It makes you wonder what kind of experimental drugs are in use today, doesn't it?

Cobblestones said:

Thanks for the link, Doctor. That was hilarious. Anyway, I think I have now a better understanding of RSR-13. It makes you wonder what kind of experimental drugs are in use today, doesn't it?

In my case---yes. For those that root for Slipstream doper denial pretext cover-ups, no!

Just remember, WADA, UCI doping control DO NOT DISCOVER doping. Rather, they allow 99.9999% of the doping to pass w/o trace.

WADA serves the IOC. The IOC serves the TV Networks. The TV Networks showcase doped athletes and marketing themes to sell $300 sneakers, Viagra, watches and hearing aids.

Life science = Olympics and cycling

It's like that we love Doctor House, when he says something news with some excellent explanations.

poulidor said:

It's like that we love Doctor House, when he says something news with some excellent explanations.

Precisely. Doctor House, bring it on. What other experimental drugs have been in use, how do they work, and why aren't they detected by tests?

Cobblestones said:

Precisely. Doctor House, bring it on. What other experimental drugs have been in use, how do they work, and why aren't they detected by tests?

Forget the secretive research drugs. Plenty of 15 to 30 year old drugs that still remain untested.

exogenous testosterone (unless overdosed and not protected by sponsor)

insulin/glucose
IGF-1
IGF-3

Interleukins

Viagra (Vasodiliation)

cow blood (Hemopure, Polyheme, Actovegin)

hGH, eGH

Clomid or choroinic gondatropin (female fertility hormone, leutenizing)

The war against doping is a media created theater act. Nobody is going to cease from doping, cheating or fixing TV sport outcomes.

The bottom line is that these procedures are totally unethical! Forget about sociopaths who don't care about their bodies. How can so-called doctors morally administer these drugs? Yes, I know it's all money. It is just wrong!

I don't know about others, but I get a visceral reaction when I read these doping schedules and lists of peds. I am so vehemently opposed to drugs in my own life, so I know I am extreme. But cmon, the civil authorities really need to crack down on these doctors. Force dopers to confess and name names. The riders are at the end of the line; we need to find and SEVERLY punish the sources.

as an aside, doc, can you provide a link that discloses where laf funds are allocated. who gets these grants? what are these research facilities studying? how many of these grants fund peds and longlasting effects? is this information even available? I won't hold my breath.

Pretty much everything about Lance is a lie or a zealous secret.

The Nike supported LAF is probably a fraud. It would be shocking to learn that anything good or helpful could possibly spring from such a Nike endorsed sporting fraud, filthy doping lies, rotten litigations (Walsh, Anderson, Simeoni, SCA, London Times), harrassemnt, and empty denials.

The LAF is a federal exempt charity which need not report any details to the naive public other than the obligatory IRS 990 filing----which can be deferred 9 months after the year end, and devoid of any useful footnote disclosures, grant details, or board member (insider) compensation.

Secrecy is the key. In drug research, at horse races, on Wall Street, at the NYSE and on Charitable Foundation boards. The insiders collect the finanical benefits, the public has ZERO recourse and will believe in the miracles that Lance & his media partners invent. (eg: LIVE STRONG)

Why any CF visitor would be opposed to these brutal disclosures of fraud and doping research remains a mystery to me.

Lance has NEVER been confronted with these confict-of-interest questions and his appearance as a honest anti-doper is a pitiful.

Klodifan said:

The bottom line is that these procedures are totally unethical! Forget about sociopaths who don't care about their bodies. How can so-called doctors morally administer these drugs? Yes, I know it's all money. It is just wrong!

I don't know about others, but I get a visceral reaction when I read these doping schedules and lists of peds. I am so vehemently opposed to drugs in my own life, so I know I am extreme. But cmon, the civil authorities really need to crack down on these doctors. Force dopers to confess and name names. The riders are at the end of the line; we need to find and SEVERLY punish the sources.

as an aside, doc, can you provide a link that discloses where laf funds are allocated. who gets these grants? what are these research facilities studying? how many of these grants fund peds and longlasting effects? is this information even available? I won't hold my breath.

LAF is one of the most inspiring charities relating to the disease of cancer. It inspires and assists many people annually, and is a meaningful advocacy and cancer patient support network.

It's an example of a great athlete using his fame for a most worthwhile and enduring cause. 🙂

musette said:

It's an example of a great athlete using his fame for a most worthwhile and enduring cause.

You mean a lying doper trying to whitewash his past, much like robber barons of the gilded age became philanthropists? If Armstrong really cared about cancer patients he would stop deceiving them instead of using his LAF appearances to stroke his ego.

Doctor.House said:

Correctimundo my clever friend in yelooo.

Overdosing on any drug can be bad. Prozac to EPO to cortisone,

Widely used? Who can say. Lance and his LAF might know about RSR-13 and Actovegin (Norway cow blood product) too. Too bad we cannot read his Nike board of director minutes.

Maybe Craig Nichols knows?

Maybe a rogue scientist from Allos knows?

You can bet Michele Ferrari knows!

My good Doctor, I know for sure that LA and the USPS team were using actovegin as far back as the 1999 tour de france. Journalists from the france 3 network found traces of it in some medical waste disposed of by USPS (they tailed them in a car, then searched the stuff they fly dumped) They broadcast their findings in france after the 1999 tour.

Klodifan said:

The bottom line is that these procedures are totally unethical! Forget about sociopaths who don't care about their bodies. How can so-called doctors morally administer these drugs? Yes, I know it's all money. It is just wrong!

I don't know about others, but I get a visceral reaction when I read these doping schedules and lists of peds. I am so vehemently opposed to drugs in my own life, so I know I am extreme. But cmon, the civil authorities really need to crack down on these doctors. Force dopers to confess and name names. The riders are at the end of the line; we need to find and SEVERLY punish the sources.

I totally agree, these guys aren't doctors, they are not obeying the hippocratic oath. Guys like ferrari and feutes should be struck off the medical register. Or be arrested. They aren't doctors!

Whilst in the end the riders are responsible for what goes into their bodies, i genuinly believe the huge amount of pressure the european riders face from DS's like Bruyneel means they are victimised for the most part.

A number of laboratories working on gene sequencing have done experimental work that involved modifying the bodies of mice. By identifying specific genes and 'splicing' them into the mice they have produced variants that have prodigious strength and endurance. This work was reported in very low circulation, specialist, medical journals.
Very quickly, these labs were inundated with coaches and athletes offering their services free, as experimental subjects. This is the future. It is potentially undetectable by anything less than invasive procedures and offers hitherto undreamt of performance gains. The testers haven't even caught up with 30 year old drug protocols and this is already in the pipeline.
Yes, let them all dope and take what they like. Then we can really have a proper freak show for our delectation.

This is content for the DOPING thread and not the Grand Tours thread.

This thread is closed.