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Cancer and Oxygen

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General fitness, health and nutrition
Published
18 April 2004
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18 April 2004
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Dave Wickware
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  1. "All normal cells have an absolute requirement for oxygen, but cancer cells
    can live without oxygen - a rule without exception." - Dr. Otto Warburg,
    quoted in Philpott, page 74.

    Deprive a cell 60% of its oxygen and it will turn cancerous. - McCabe, page
    192. Deprive a cell 35% of its oxygen for 48 hours and it may become
    cancerous. - Dr. Otto Warburg. Read Dr. Warburg's papers in the Library:
    Lecture 1, Lecture 2.

    When the oxygen saturation of blood falls, conditions become ripe for the
    creation of cancer. Oxygen is removed from the arterial blood as it passes
    through the capillary system. If arterial blood is deficient in oxygen or if
    the blood flow is restricted by blocked arteries, then tissues oxygenated by
    the latter stages of the capillary system may be so deprived of oxygen as to
    become cancerous.

    Normal Metabolism vs. Cancer Metabolism

    "The fuel on which the body's cells run is called adenosine triphosphate
    (ATP). ATP must be created by all cells, including cancer cells, for energy.
    The biochemical process in which ATP is created is called oxidation
    phosphorylation and is oxygen-dependent. Healthy cells require the
    conditions of alkalinity and high molecular oxygen (O2) to produce ATP and
    function properly. In contrast, non-oxygen-respiratory organisms - like
    cancer cells - make ATP by fermentation phosphorylation, which requires the
    conditions of acidity and low oxygen to function, and actually produces
    additional acids." - Philpott, page 75.

    Cellular Respiration

    The human body's main fuel is a simple sugar called glucose. Glucose comes
    from the plants we eat. Through photosynthesis, plants use light energy to
    produce glucose and oxygen from carbon dioxide and water.
    Carbon dioxide + water + energy --> glucose + oxygen

    Plants then use the glucose to create cellulose and complex carbohydrates.
    When we eat the plants, the complex carbohydrates are broken down by our
    digestive system into glucose. Then this food energy is converted to
    chemical energy by a series of reactions known as cellular respiration.
    Aerobic respiration uses oxygen.
    Glucose + oxygen --> carbon dioxide + water + energy
    This reaction occurs in mitochondria in cells. Aerobic respiration extracts
    the maximum amount of energy from glucose, because the molecule is
    completely broken down.

    When the supply of oxygen is insufficient, there is a back-up system known
    as anaerobic respiration, that can release energy without oxygen.
    Glucose --> lactic acid + energy
    This reaction occurs in the cytoplasm of the cell. It does not put any extra
    pressure on the respiratory or circulatory systems, because it does not
    produce carbon dioxide, but it can cause muscle stiffness after exercise.
    Cancer cells have either wholly or partially switched to anaerobic
    respiration.

    "The ideal task of cancer therapy is to restore the function of the
    oxidizing systems in the entire organism." - Dr. Max Gerson, page 7.

    Aerobic cellular respiration creates as many as 36 ATP molecules from each
    glucose molecule, and anaerobic respiration creates only 2 ATP molecules.
    Anaerobic respiration releases one eighteenth of the available energy.
    Cancer cells must feel very tired!

    For more information regarding cellular respiration, you can do a search of
    the Internet for subjects such as cellular respiration, cellular biology and
    ATP, adenosine triphosphate, healthy mitochondria, Dr. Otto Warburg.

  2. Quoted message said:

    Subject: Cancer and Oxygen
    From: "Dave Wickware" [email hidden]
    Date: 4/17/2004 6:36 PM Pacific Daylight Time
    Message-id: <[email hidden]>

    Quoted message said:

    Deprive a cell 60% of its oxygen and it will turn cancerous. - McCabe, page

    ahhh now I see where spammin DAve got his previous statement...what he doesn't
    understand is that first he describes "normal O2 sats of 98"...then throws in
    "people with cancer have 60"

    davey..."deprive a cell 60% of its oxygen" and "a person have an O2 sat of 60"
    are...well ....not the same thing...

    again you demonstrate your ignorance of human physiology...cellular
    chemistry..physics and just about every other scientific discipline..

    maybe some more ginseng for you
    hawki.....

  3. "Hawki63" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:
    Quoted message said:

    Subject: Cancer and Oxygen
    From: "Dave Wickware" [email hidden]
    Date: 4/17/2004 6:36 PM Pacific Daylight Time
    Message-id: <[email hidden]>

    Quoted message said:

    Deprive a cell 60% of its oxygen and it will turn cancerous. - McCabe,


    page

    Quoted message said:


    ahhh now I see where spammin DAve got his previous statement...what he


    doesn't

    Quoted message said:

    understand is that first he describes "normal O2 sats of 98"...then throws


    in

    Quoted message said:

    "people with cancer have 60"

    davey..."deprive a cell 60% of its oxygen" and "a person have an O2 sat of


    60"

    Quoted message said:

    are...well ....not the same thing...

    again you demonstrate your ignorance of human physiology...cellular
    chemistry..physics and just about every other scientific discipline..

    maybe some more ginseng for you
    hawki.....

    "CLUE TO SPREAD OF CANCER DISCOVERED"
    --------------------------------------

    " Critical clues explaining why cancerous cells spread, uncovered by a
    biologist at Queen's University, may have important implications for
    future treatments, according to a leading international journal.

    The findings of Dr. Charles Graham and a team of researchers at Queen's
    University in Kingston, Ontario, published in the current issue of the
    International Journal of cancer, suggest a link between oxygen levels in
    cancerous tumors and the spread of the disease to other parts of the
    body.

    "Our research shows that the low levels of oxygen in malignant tumors
    enhance the ability of the tumor cells to spread," said Dr. Graham. "So
    by manipulating oxygen levels within the tumor, we may be able to
    control the spreading of cancer to different parts of the body".

    "We took breast cancer cells and put them under conditions of low oxygen
    and we saw the cells became more aggressive and invasive..."

    "To spread, tumor cells must be able to break down and invade
    surrounding tissue barriers. Dr. Graham's research shows that hypoxia,
    or low oxygen levels, in the tumor mass plays an important role in
    stimulating the processes required for metastasis."

    - National Post reporter Tom Arnold

  4. In article <[email hidden]>,

    Dave Wickware said:

    Deprive a cell 60% of its oxygen and it will turn cancerous. - McCabe, page
    192. Deprive a cell 35% of its oxygen for 48 hours and it may become
    cancerous. - Dr. Otto Warburg. Read Dr. Warburg's papers in the Library:
    Lecture 1, Lecture 2.

    Interesting. I personally have done many experiments using hypoxia
    chambers, in which I deprived normal cells or cancer cells of 25-95% of
    their oxygen for varying periods of time. Not one of the normal cells
    ever turned cancerous. They did, however, increase the secretion of all
    sorts of proangiogenic factors, and many of them died.

    Quoted message said:

    When the oxygen saturation of blood falls, conditions become ripe for the
    creation of cancer. Oxygen is removed from the arterial blood as it passes
    through the capillary system. If arterial blood is deficient in oxygen or if
    the blood flow is restricted by blocked arteries, then tissues oxygenated by
    the latter stages of the capillary system may be so deprived of oxygen as to
    become cancerous.

    Does anyone here see the contradiction in altie claims? Alties
    frequently claim that cancer (along with many other chronic diseases)
    can be prevented or treated with antioxidants, don't they? If that were
    the case, then wouldn't decreasing the oxygen tension actually be a good
    thing, as it would result in fewer free radicals being formed? Yet,
    here, the claim is that LOW oxygen tension is what causes cancer.

    Which is it?

    --
    Orac |"A statement of fact cannot be insolent."
    |
    |"If you cannot listen to the answers, why do you
    | inconvenience me with questions?"

  5. In article <[email hidden]>,

    Dave Wickware said:

    "Hawki63" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:
    Quoted message said:

    Subject: Cancer and Oxygen
    From: "Dave Wickware" [email hidden]
    Date: 4/17/2004 6:36 PM Pacific Daylight Time
    Message-id: <[email hidden]>

    Quoted message said:

    Deprive a cell 60% of its oxygen and it will turn cancerous. - McCabe,


    page

    Quoted message said:


    ahhh now I see where spammin DAve got his previous statement...what he


    doesn't

    Quoted message said:

    understand is that first he describes "normal O2 sats of 98"...then throws


    in

    Quoted message said:

    "people with cancer have 60"

    davey..."deprive a cell 60% of its oxygen" and "a person have an O2 sat of


    60"

    Quoted message said:

    are...well ....not the same thing...

    again you demonstrate your ignorance of human physiology...cellular
    chemistry..physics and just about every other scientific discipline..

    maybe some more ginseng for you
    hawki.....

    "CLUE TO SPREAD OF CANCER DISCOVERED"
    --------------------------------------

    " Critical clues explaining why cancerous cells spread, uncovered by a
    biologist at Queen's University, may have important implications for
    future treatments, according to a leading international journal.

    The findings of Dr. Charles Graham and a team of researchers at Queen's
    University in Kingston, Ontario, published in the current issue of the
    International Journal of cancer, suggest a link between oxygen levels in
    cancerous tumors and the spread of the disease to other parts of the
    body.

    "Our research shows that the low levels of oxygen in malignant tumors
    enhance the ability of the tumor cells to spread," said Dr. Graham. "So
    by manipulating oxygen levels within the tumor, we may be able to
    control the spreading of cancer to different parts of the body".

    "We took breast cancer cells and put them under conditions of low oxygen
    and we saw the cells became more aggressive and invasive..."

    "To spread, tumor cells must be able to break down and invade
    surrounding tissue barriers. Dr. Graham's research shows that hypoxia,
    or low oxygen levels, in the tumor mass plays an important role in
    stimulating the processes required for metastasis."

    I believe you mean this study:

    http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&d
    opt=Abstract&list_uids=9935166

    First off, these cells are already cancerous, which is a very different
    claim from saying that low oxygen turns normal cells into cancer cells.
    Second, they are talking about hypoxia, not anoxia. Third, as the
    authors themselves speculate in the discussion (look up the full article
    yourself, if you don't believe me), part of the reason that hypoxia may
    increase tumor invasiveness is that hypoxia is a VERY potent stimulus
    for releasing proangiogenic factors to stimulate the ingrowth of new
    blood vessels, something tumors would be unlikely to do if they were
    very happy with the low oxygen tension.

    --
    Orac |"A statement of fact cannot be insolent."
    |
    |"If you cannot listen to the answers, why do you
    | inconvenience me with questions?"

  6. Quoted message said:

    Subject: Re: Cancer and Oxygen
    From: Orac [email hidden]
    Date: 4/18/2004 6:56 AM Pacific Daylight Time
    Message-id: <[email hidden]>

    snip

    Quoted message said:

    Yet,
    here, the claim is that LOW oxygen tension is what causes cancer.

    Which is it?

    Orac

    if spammin Dave had half a brain he might be able to understand this..

    however his one brain cell is lonely..

    so to him "oxygen saturation" and depriving a cell of oxygen are one and the
    same

    remember he is also the one that stated "cancer cells are created at
    conception"

    it is really hard to accept that he can be so stupid...

    hawki.....

  7. (Hawki63) said:

    however his one brain cell is lonely..

    two brain cells connected by a spirochaete
    --

    W_B

    Take out the G'RBAGE
    [email hidden]

  8. Quoted message said:
    (Hawki63) said:

    however his one brain cell is lonely..

    two brain cells connected by a spirochaete
    --

    Syphillis is a spirochaete........

    Quoted message said:

    W_B

  9. In article <[email hidden]>,

    W_B said:
    (Hawki63) said:

    however his one brain cell is lonely..

    two brain cells connected by a spirochaete

    Which is why you never want to give him penicillin; as it will sever
    that one connection. ;-)

    --
    Orac |"A statement of fact cannot be insolent."
    |
    |"If you cannot listen to the answers, why do you
    | inconvenience me with questions?"

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