BCAA's and irritability ?

mark boucher said:

Hi,

I've been taking BCAA's for two weeks now, and I've noticed beyond

any

Quoted message said:

doubt (as this is the ONLY supplement I've used for those two weeks),
that although they first appear to make me mellower, I've found them
to actuallly increase aggression noticeably, or if you prefer
irritability.

My question is ; Does anyone on this forum know *why* they can cause
aggressiveness ? By the way, I'm only using 2 G/day.

Maybe one of our biochem geeks will respond, but, here's a theory.
BCAAs can compete with phenylalanine. Phenylalanine is a precursor of
many neurotransmitters. By effectively decreasing the action of
phenylalanine, you could be screwing with your mind...literally.

Or not.

David

mark boucher said:

My question is ; Does anyone on this forum know *why* they can cause
aggressiveness ?

You may find some interesting info here about seratonin function:
http://www.vrp.com/art/800.asp

<<joni>>

OmManiPadmeOmelet said:

JMW said:

OmManiPadmeOmelet said:

I wonder if the regular use of Melatonin then might help him counteract
the irritability? It's supposed to increase Serotonin output, correct?

You have it ass-backwards.

5-hydroxytryptamine converts to N-acetyl-5-methoxytryptamine by means
of arylalkylamine N-acetyltransferase.

Google that one, sockpuppet.

That's why I posted it as a question... ;-)
I was not sure about it.

So, how would YOU suggest he counters the irritability?

BCAAs can compete with tryptophan, tyrosine, and phenyalanine.

If he thinks that's the problem, he can supplement with tyrosine and
5-HTP.
--

JMW
http://www.rustyiron.net

In article <[email hidden]>,

JMW said:

OmManiPadmeOmelet said:

JMW said:

OmManiPadmeOmelet <[email hidden]> wrote:
>
>I wonder if the regular use of Melatonin then might help him counteract
>the irritability? It's supposed to increase Serotonin output, correct?

You have it ass-backwards.

5-hydroxytryptamine converts to N-acetyl-5-methoxytryptamine by means
of arylalkylamine N-acetyltransferase.

Google that one, sockpuppet.

That's why I posted it as a question... ;-)
I was not sure about it.

So, how would YOU suggest he counters the irritability?

BCAAs can compete with tryptophan, tyrosine, and phenyalanine.

If he thinks that's the problem, he can supplement with tyrosine and
5-HTP.

I'd heard of 5-HTP...
I've just not tried it yet or looked for it.
Does it work as advertised?

Just about everyone on the planet could use a tranquilizer about now. <G>
--
Om.

"My mother never saw the irony in calling me a son-of-a-[censored]." -Jack Nicholson

"Usenet Posting" <[email hidden]> wrote

Quoted message said:

JMW said:

OmManiPadmeOmelet said:

JMW <[email hidden]> wrote:
> OmManiPadmeOmelet <[email hidden]> wrote:
> >I wonder if the regular use of Melatonin then might help him
> >counteract
> >the irritability? It's supposed to increase Serotonin output, correct?
>
> You have it ass-backwards.
>
> 5-hydroxytryptamine converts to N-acetyl-5-methoxytryptamine by means
> of arylalkylamine N-acetyltransferase.
>
> Google that one, sockpuppet.

That's why I posted it as a question... ;-)
I was not sure about it.

So, how would YOU suggest he counters the irritability?

BCAAs can compete with tryptophan, tyrosine, and phenyalanine.

If he thinks that's the problem, he can supplement with tyrosine and
5-HTP.

If one finds valium useful to blunt mild anxiety episodes what OTC
drug would be closest in function? I have looked but anything you can
take as a GABA precursor seems to have molecules to large to pass
through the gut. Also, I have seen nothing at all that could even
come close to matching the benzos for improving the binding of GABA to
the receptor.

Any thoughts?

Chocolate.

David

Usenet Posting said:

JMW said:

OmManiPadmeOmelet said:

JMW <[email hidden]> wrote:

> OmManiPadmeOmelet <[email hidden]> wrote:
> >
> >I wonder if the regular use of Melatonin then might help him counteract
> >the irritability? It's supposed to increase Serotonin output, correct?
>
> You have it ass-backwards.
>
> 5-hydroxytryptamine converts to N-acetyl-5-methoxytryptamine by means
> of arylalkylamine N-acetyltransferase.
>
> Google that one, sockpuppet.

That's why I posted it as a question... ;-)
I was not sure about it.

So, how would YOU suggest he counters the irritability?

BCAAs can compete with tryptophan, tyrosine, and phenyalanine.

If he thinks that's the problem, he can supplement with tyrosine and
5-HTP.

If one finds valium useful to blunt mild anxiety episodes what OTC
drug would be closest in function? I have looked but anything you can
take as a GABA precursor seems to have molecules to large to pass
through the gut. Also, I have seen nothing at all that could even
come close to matching the benzos for improving the binding of GABA to
the receptor.

Any thoughts?

I think I read that valerian root has some similar properties to
valium. It's usually used to help people get to sleep at night, but
it tends to only work for this if used seldomly, otherwise a tolerance
gets built up.

-----------
Proton Soup

"And all this peace has been deceiving,
I need some wind to get me sailing"

Usenet Posting said:

JMW said:

OmManiPadmeOmelet said:

JMW <[email hidden]> wrote:
> OmManiPadmeOmelet <[email hidden]> wrote:
> >
> >I wonder if the regular use of Melatonin then might help him counteract
> >the irritability? It's supposed to increase Serotonin output, correct?
>
> You have it ass-backwards.
>
> 5-hydroxytryptamine converts to N-acetyl-5-methoxytryptamine by means
> of arylalkylamine N-acetyltransferase.
>
> Google that one, sockpuppet.

That's why I posted it as a question... ;-)
I was not sure about it.

So, how would YOU suggest he counters the irritability?

BCAAs can compete with tryptophan, tyrosine, and phenyalanine.

If he thinks that's the problem, he can supplement with tyrosine and
5-HTP.

If one finds valium useful to blunt mild anxiety episodes what OTC
drug would be closest in function? I have looked but anything you can
take as a GABA precursor seems to have molecules to large to pass
through the gut. Also, I have seen nothing at all that could even
come close to matching the benzos for improving the binding of GABA to
the receptor.

Any thoughts?

I'm not talking about general mood dysfunctions, which should probably
be handled pharmaceutically, and more importantly, in conjunction with
psychotherapy. I'm merely talking about equalizing the substrate
amino acids or their metabolites.
--

JMW
http://www.rustyiron.net

In article <[email hidden]>,

Usenet Posting said:

JMW said:

OmManiPadmeOmelet said:

JMW <[email hidden]> wrote:

> OmManiPadmeOmelet <[email hidden]> wrote:
> >
> >I wonder if the regular use of Melatonin then might help him counteract
> >the irritability? It's supposed to increase Serotonin output, correct?
>
> You have it ass-backwards.
>
> 5-hydroxytryptamine converts to N-acetyl-5-methoxytryptamine by means
> of arylalkylamine N-acetyltransferase.
>
> Google that one, sockpuppet.

That's why I posted it as a question... ;-)
I was not sure about it.

So, how would YOU suggest he counters the irritability?

BCAAs can compete with tryptophan, tyrosine, and phenyalanine.

If he thinks that's the problem, he can supplement with tyrosine and
5-HTP.

If one finds valium useful to blunt mild anxiety episodes what OTC
drug would be closest in function? I have looked but anything you can
take as a GABA precursor seems to have molecules to large to pass
through the gut. Also, I have seen nothing at all that could even
come close to matching the benzos for improving the binding of GABA to
the receptor.

Any thoughts?

--
I've perfected humility.

Well, if you want to get into herbals... ;-)

Valerian root, epecially used as a tincture, is a great tranquilizer.
On a molecular level Valerian root has a chemistry similar to valium.

Another good one, believe it or not, is simple catmint (catnip). Brew a
strong infusion of that and it gives a rather good buzz! I've done it
accidently when using it as a cough remedy.

Skullcap is supposed to be another, but I've not experimented with it
much. It tends to give me a hangover.

Fresh basil used in place of lettuce in salads and sandwiches is not
only delicious, but takes me down nicely if I'm in an irritable or
anxious mood. I grow it every year in my herb garden, but it's an annual
so is only available seasonally.

If you are desperate, there is always San Pedro cactus extract. <eg>
--
Om.

"My mother never saw the irony in calling me a son-of-a-[censored]." -Jack Nicholson

In article <[email hidden]>,

David Cohen said:

"Usenet Posting" <[email hidden]> wrote

Quoted message said:

JMW said:

OmManiPadmeOmelet <[email hidden]> wrote:
> JMW <[email hidden]> wrote:
>> OmManiPadmeOmelet <[email hidden]> wrote:
>> >I wonder if the regular use of Melatonin then might help him
>> >counteract
>> >the irritability? It's supposed to increase Serotonin output, correct?
>>
>> You have it ass-backwards.
>>
>> 5-hydroxytryptamine converts to N-acetyl-5-methoxytryptamine by means
>> of arylalkylamine N-acetyltransferase.
>>
>> Google that one, sockpuppet.
>
>That's why I posted it as a question... ;-)
>I was not sure about it.
>
>So, how would YOU suggest he counters the irritability?

BCAAs can compete with tryptophan, tyrosine, and phenyalanine.

If he thinks that's the problem, he can supplement with tyrosine and
5-HTP.

If one finds valium useful to blunt mild anxiety episodes what OTC
drug would be closest in function? I have looked but anything you can
take as a GABA precursor seems to have molecules to large to pass
through the gut. Also, I have seen nothing at all that could even
come close to matching the benzos for improving the binding of GABA to
the receptor.

Any thoughts?

Chocolate.

David

Good one! ;-)
I'd forgotten that one as I've been dieting too long...
Chocolate, alas, is a rare treat at the moment. <sigh>

Hershey's syrup is a great sex toy too.

Oh yeah! There is another tranqulizer!
A good orgasm.
--
Om.

"My mother never saw the irony in calling me a son-of-a-[censored]." -Jack Nicholson

Usenet Posting said:

JMW said:

OmManiPadmeOmelet said:

JMW <[email hidden]> wrote:

> OmManiPadmeOmelet <[email hidden]> wrote:
> >
> >I wonder if the regular use of Melatonin then might help him counteract
> >the irritability? It's supposed to increase Serotonin output, correct?
>
> You have it ass-backwards.
>
> 5-hydroxytryptamine converts to N-acetyl-5-methoxytryptamine by means
> of arylalkylamine N-acetyltransferase.
>
> Google that one, sockpuppet.

That's why I posted it as a question... ;-)
I was not sure about it.

So, how would YOU suggest he counters the irritability?

BCAAs can compete with tryptophan, tyrosine, and phenyalanine.

If he thinks that's the problem, he can supplement with tyrosine and
5-HTP.

If one finds valium useful to blunt mild anxiety episodes what OTC
drug would be closest in function? I have looked but anything you can
take as a GABA precursor seems to have molecules to large to pass
through the gut. Also, I have seen nothing at all that could even
come close to matching the benzos for improving the binding of GABA to
the receptor.

There is still nothing better than Valium, which is fast acting, has a
long half-life (it is efficacious in excess of 24 hours) and is very
effective. However, it is sleep inducing and habit forming.

Fine if you are only going to use it infrequently to cope with
periodic bouts of anxiety. Try not to use more than 5 mg a day, and do
not use with alcohol!!

You should be looking at why you are experiencing anxiety and deal
with the root cause with a view to eradicating it.

Have a great weekend - I am!! ;o)

Charles said:

There is still nothing better than Valium, which is fast acting, has a
long half-life (it is efficacious in excess of 24 hours) and is very
effective. However, it is sleep inducing and habit forming.

First hand experience, no doubt.

Quoted message said:

Fine if you are only going to use it infrequently to cope with
periodic bouts of anxiety. Try not to use more than 5 mg a day, and do
not use with alcohol!!

<hiccup>

Quoted message said:

You should be looking at why you are experiencing anxiety and deal
with the root cause with a view to eradicating it.

Have a great weekend - I am!! ;o)

Spending the weekend with your old pals Johnny Walker & Jim Beam?

Thanks all for chyming in--I appreciate it. I too from my reading tend
to think one possible cause for this rise in aggression could be
explained by the BCAA's decreasing availability of both 5-HT as well
as Tyrosine to the brain. I know that, and that is exactly why I'm
taking BCAA's, that the latter have some indirect impact on GABA
transmission. To make a long story short, I read Dr. Eric Braverman's
book ; The edge effect, and found after taking the *nature assessment*
test, that I was dopamine dominant and that I was severely lacking in
GABA. So far I'm very satisfied with the results I got out of what is
outlined in the book--by correcting my GABA deficiency, I
automatically stopped the sugar cravings--this part is especially
welcome, as I don't want to end up with type diabetes, with it's
concomitant complications. My sex drive was totally shot, but by
raising GABA levels, it made some difference in that department. I'm
very fond of highly complicated topics, and I've been experimenting
with tyrosine, GABA precusors (as actual GABA caps. are known to not
readily cross the BBB). I've used DLPA, 5-HTP, L-theanine, magnesium,
glycine etc...the outcome is ; it can get darned tricky to play with
one's brain neurotransmitters levels without causing imbalance
somewhere else, but I think by being very observant, and with using
what it is science has known, it is possible to acheive, great
physical as well as psychological well-being--it is known that
psychology, and personality are of chemistry nature. As I''ve been
told once ; ''ask a drug addict, or an alcoholic whether brain
chemistry and/or personality can be altered using drugs''.

I can't seem to recall the name of the poster who said that ; *pretty
much everyone on this planet could use a tranquilizing pill*--how true
:-)!! People are all damn stressed about this or that, money matters
etc...and this includes the person typing this posting, though I'm
glad of what I've accomplished WRT managing stress levels.

Anyway, thanks all for chyming in.

Marc

JMW said:

Justin Case <[email hidden]> wrote:

Quoted message said:

Quoted message said:

Oh, you've herd this before? Why am I not surprised?
Retarded, drunken old turd.

http://www.looevalleyrotary.org/JH%20Trafalgar.jpg

Hmmm, interesting. I wonder how many of his posts would pass "The
Four Way Test"?

From http://www.looevalleyrotary.org/:

1. Is it the Truth?

2. Is it Fair to all Concerned?

3. Will it Build Goodwill and Better Friendships?

4. Will it be Beneficial to all Concerned?

Ellis

<Ellis> wrote in message news:[email hidden]...

Quoted message said:

JMW said:

Justin Case <[email hidden]> wrote:

Quoted message said:

Quoted message said:

Oh, you've herd this before? Why am I not surprised?
Retarded, drunken old turd.

http://www.looevalleyrotary.org/JH%20Trafalgar.jpg

Hmmm, interesting. I wonder how many of his posts would pass "The
Four Way Test"?

From http://www.looevalleyrotary.org/:

1. Is it the Truth?

2. Is it Fair to all Concerned?

3. Will it Build Goodwill and Better Friendships?

4. Will it be Beneficial to all Concerned?

Ellis

Ellis, maybe your favourite movie was The Stepford Wives?

What about this test

1. Is it entertaining?
2. Is it provocative?
3. Is it interesting?
4. Is it stimulating?

Ellis said:

JMW said:

Justin Case said:

Oh, you've herd this before? Why am I not surprised?
Retarded, drunken old turd.

http://www.looevalleyrotary.org/JH%20Trafalgar.jpg

Hmmm, interesting. I wonder how many of his posts would pass "The
Four Way Test"?

From http://www.looevalleyrotary.org/:

1. Is it the Truth?

2. Is it Fair to all Concerned?

3. Will it Build Goodwill and Better Friendships?

4. Will it be Beneficial to all Concerned?

I don't know. Maybe those words have a different meaning in Liskeard.
Do they speak a different English dialect there?
--

JMW
http://www.rustyiron.net

Ellis said:

JMW said:

Justin Case <[email hidden]> wrote:

Quoted message said:

Quoted message said:

Oh, you've herd this before? Why am I not surprised?
Retarded, drunken old turd.

http://www.looevalleyrotary.org/JH%20Trafalgar.jpg

Hmmm, interesting. I wonder how many of his posts would pass "The
Four Way Test"?

From http://www.looevalleyrotary.org/:

1. Is it the Truth?

2. Is it Fair to all Concerned?

3. Will it Build Goodwill and Better Friendships?

4. Will it be Beneficial to all Concerned?

In the unlikely event that you should be invited to become a Rotarian,
let alone become its President, you may get to understand what it's
all about.

Until then you plebeian fool you'll have to keep your nose pressed
against the glass and be satisfied with gawping at a world that is
denied you!! ;o)

JMW said:

I don't know. Maybe those words have a different meaning in Liskeard.
Do they speak a different English dialect there?

Well there is Cornish, but I'm pretty sure that ain't Cornish.

Ellis

Ellis said:

JMW said:

I don't know. Maybe those words have a different meaning in Liskeard.
Do they speak a different English dialect there?

Well there is Cornish, but I'm pretty sure that ain't Cornish.

Is there some Cornish Medal of Honor, sort of like the American
Congressional Medal of Honor? He really seems to like wearing that
medal on a ribbon around his neck. I think he's wearing it here, too:

http://www.rotaryhistoryfellowship.org/committee/images/hudson.jpg
--

JMW
http://www.rustyiron.net

JMW said:

Ellis said:

JMW said:

I don't know. Maybe those words have a different meaning in Liskeard.
Do they speak a different English dialect there?

Well there is Cornish, but I'm pretty sure that ain't Cornish.

Is there some Cornish Medal of Honor, sort of like the American
Congressional Medal of Honor? He really seems to like wearing that
medal on a ribbon around his neck. I think he's wearing it here, too:

http://www.rotaryhistoryfellowship.org/committee/images/hudson.jpg

Different "medals" if you look closely JW, they are both meritorious
but hardly as distinguished as the "Congressional Medal of Honour"!!

You missed the medal on the lapel!!

I think it is so quaint the way you talk around me, is that what you
describe as ignoring someone? <smiling indulgently>

However, it's no good asking Ellis about these things, as he won't
have any more idea than you have. I know you are always attempting to
rally a few more to your cause, as you are bereft of any support these
days, but you are scraping the barrel somewhat!!

As you are upping the tempo again, albeit via the third-party
Williams' ignoring method, is it time I started putting up some tasty
Google search criteria?

How about "fetal alcohol syndrome" or Nandrolone ® ? I'm up for some
sport if you are!! ;o)

Have a great Sunday and try and get out a little - you appear to have
too much time on your hands!!