Am J Cardiol. 2004 Mar 1;93(5):559-62.
Association of ferritin and lipids with C-reactive protein.
Mainous AG 3rd, Wells BJ, Everett CJ, Gill JM, King DE.
Department of Family Medicine, Medical University of South
Carolina, Charleston, South Carolina 29425, USA.
[email hidden]
C-reactive protein (CRP) and lipids (e.g., low-density
lipoprotein [LDL]) are both markers of cardiovascular
disease risk, yet they are not highly correlated. Oxidative
stress of lipids induced by iron may play a role in vascular
inflammation, as indicated by CRP. The purpose of this study
was to examine, in a representative sample of United States
adults, the relation between ferritin, lipids, and CRP. We
analyzed data on adults (aged > or =25 years) in the
National Health and Nutrition Examination Survey III, a
national public-use data set collected between 1988 and
1994. Ferritin, total cholesterol, LDL, high-density
lipoprotein, and ferritin-lipid combinations were analyzed
in relation to CRP in age-, gender-, and race-adjusted
models as well as models with other potential confounding
variables. In adjusted models, neither elevated ferritin
(odds ratio [OR] 1.11, 95% confidence interval [CI] .94 to
1.32) nor elevated LDL was significantly associated with
elevated CRP (OR 1.03, 95% CI 0.79 to 1.33). Patients with
elevated ferritin and elevated LDL were more likely to have
elevated CRP (OR 1.68; 95% CI 1.06 to 2.68). Patients with
elevated ferritin and low high-density lipoprotein were also
more likely to have elevated CRP (OR 1.71; 95% CI 1.28 to
2.27). These results suggest that both iron and lipids
induce inflammation. Future research needs to focus on
preventive medicine to decrease iron in patients with
elevated lipids.
PMID: 14996579 [PubMed - in process]
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