Wed said:anyhow, given your dawn phenomenon, for your background i'd suggest taking Humulin-UL in the "AM"
and a greater amount of Humulin-L in the "PM". i'd suggest somthing like noon and midnight.
whatever do stick to a 12 hour separation of these background shots. start with noon and midnight
and adjust from there based on what works best for you
btw, i assumed that you are doing MDI/DAFNE. my comments (below) mainly apply for an
MDI/DAFNE routine
anyhow, for some insight into understanding the profile (and long residual of UL) that one gets
from a single shot of UL, see p.s. of the Owens study. the "human"-UL has residual that clearly
exceeds 48+ hours
Lente is best thought of as a separate shot of 30% SL (SemiLente) and a separate shot of 70% UL
(UltraLente)
for a better understanding of taking 2x of UL, and the resulting profile and how it varies if you
vary the shot amounts and/or times, give Aida a try (www.2aida.org/aida/insulin.htm)
btw, you'll have to mickey mouse it a bit
(i.e. in addition to the two shots of UL, you'll have to do something like add a single shot of .1
unit of a meal insulin). and while Aida uses a large number of different insulin names, there
are in fact only a few different profiles
with regard to goiing to Lantus, why would you do that? Lantus costs more than twice as much as "human"-
UL and is less robust and way less flexible in that you can't mix it with anything. not to mention
that those who are using Lantus are playing guinea pig for Aventis
my own use of Aida has suggested that a 9u:10u (at noon:midnight) ratio gives a decent overall
profile (i.e. curve) when you have a rigid 12 hours between the shots (try rising and bedtime and
see how the curve quickly moves away from flat)
so if you need a lot of SemiLente for your dawn phenomena, then you'd only take Lente at bedtime,
namely 14.3 units of Lente, coz that has 10 units of UL in it and you'd therefore be getting 4.3
units of SL to help with your high(er) morning
j/g values
if that's too much SL, then go to mixing UL and L at bedtime and start saving your almost empty
bottles of L and U
you're also going to have to do a lot of 3:00AM testing to keep track of how you're doing and skip a
lot of meals during the day too (to see how close you've got your background amounts to your true
basal needs)
also get some 1cc 28 gage syringes and use them to put precise amounts of UL and L into the near
empty bottle coz that's a lot easier (and more accurate) than mixing by hand every time at bedtime
when you are tired (especially if your eyesight isn't good)
with a permanent marker (or better an ice pick), write or scratch "mix" on the label of the in use
vial of mixed U and L so that there's no question in your mind of what's in any given bottle that
you've got
bill t1 since '57, ex 8-yr pumper, beef/pork-L 2x, simple MDI/DAFNE
| in thread: "Activity Curves (Was: Changing from NPH to Ultralente)"
| 3/8/99 12:04:33 -0800, Michel Martin wrote:
<big snip>
|| (See Human, Porcine and Bovine Ultralente Insulin, by D.R. Owens, et al, Diabetic Medicine,
|| July/Aug, 1986, p. 326-329).
||
|| time Pork-UL beef-UL "human"-UL hrs
|| 2 .01 inch .00 inch .15 inch 3 xx xx .30
|| 4 .46 .00 .80
|| 5 .55 .23 .98
|| 6 .62 .25 .98
|| 7 .68 xx 1.23
|| 8 .68 .30 1.30 10 1.01 .42 1.54 12 1.17 .52 1.56 14 1.33 .55 1.72 (corresponds 0.05
|| nmol/L) 16 1.41 .55 1.66 18 1.23 .60 1.66 20 1.14 .57 1.41
|| 22 .86 .49 1.11
|| 24 .73 .50 .98
|| 26 .65 .49 .92
|| 28 .54 .47 .86
|| 30 .48 .39 .80
|| 32 .48 .39 .74 34 xx xx .68 36 xx xx .62