Diet / oxidative stress / hypertension / inflammation

And what exactly are we to make of this, how does it relate
to any body of theory, to what practical use is it, and
toward what goal can it be applied? Without this information
it is but another random abstract plucked from the web, one
among thousands of such.

Quoted message said:

Subject: Re: Diet / oxidative stress / hypertension / inflammation
From: [email hidden]
Date: 4/24/2004 3:31 PM Mountain Daylight Time
Message-id: <[email hidden]>

Proc Natl Acad Sci U S A. 2004 Apr 21 [Epub ahead of print]
Related Articles, Links

Dietary approach to attenuate oxidative stress,
hypertension, and inflammation in the cardiovascular system.

Wu L, Ashraf MH, Facci M, [censored] R, Paterson PG, Ferrie A,
Juurlink BH.

Departments of (*)Anatomy and Cell Biology and
()Physiology, College of Medicine, and ()College of
Pharmacy and Nutrition, University of Saskatchewan,
Saskatoon, SK, Canada S7N 5E5.

Imbalance between production and scavenging of superoxide
anion results in hypertension by the inactivation of nitric
oxide, and the increased oxidative stress from the resultant
peroxynitrite that is produced promotes inflammatory
processes such as atherosclerosis. Induction of phase 2
proteins promotes oxidant scavenging. We hypothesized that
intake of dietary phase 2 protein inducers would ameliorate
both hypertension and atherosclerotic changes in the
spontaneously hypertensive stroke-prone rat. For 5 days/week
for 14 weeks, we fed rats 200 mg/day of dried broccoli
sprouts that contained glucoraphanin, which is metabolized
into the phase 2 protein-inducer sulforaphane (Group A),
sprouts in which most of the glucoraphanin was destroyed
(Group B), or no sprouts (Group C). After 14 weeks of
treatment, no significant differences were seen between rats
in Groups B and C. Rats in Group A had significantly
decreased oxidative stress in cardiovascular and kidney
tissues, as shown by increased glutathione (GSH) content and
decreased oxidized GSH, decreased protein nitrosylation, as
well as increased GSH reductase and GSH peroxidase
activities. Decreased oxidative stress correlated with
better endothelial-dependent relaxation of the aorta and
significantly lower (20 mm Hg) blood pressure. Tissues from
Groups B and C had considerable numbers of infiltrating
activated macrophages, indicative of inflammation, whereas
animals in Group A had few detectable infiltrating
macrophages. There is interest in dietary phase 2 protein
inducers as means of reducing cancer incidence. We conclude
that a diet containing phase 2 protein inducers also reduces
the risk of developing cardiovascular problems of
hypertension and atherosclerosis.

PMID: 15103025 [PubMed - as supplied by publisher]

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And what exactly are we to make of this, how does it relate
to any body of theory, to what practical use is it, and
toward what goal can it be applied? Without this information
it is but another random abstract plucked from the web, one
among thousands of such.

<[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

And what exactly are we to make of this, how does it
relate to any body of theory, to what practical use is it,
and toward what goal can it be applied? Without this
information it is but another random abstract plucked from
the web, one among thousands of such.

Eat your vegetables especially broccoli, brussels sprouts,
kohlrabi, broccoli seed sprouts, and turnips?

Of course, Doe is on to his next posting. and you will be on
top of it, latched like a male toad on top of the female of
the species.

Life is good...........hang in there Doe! You are providing
purpose and direction to Mark De Toad.

If you suffer from hypertension it makes you consider eating
more broccoli I suppose!! 😉

<[email hidden]> wrote in message -"]news:[email hidden]-
net.com...

Quoted message said:

And what exactly are we to make of this, how does it
relate to any body of theory, to what practical use is it,
and toward what goal can it be applied? Without this
information it is but another random abstract plucked from
the web, one among thousands of such.