Ann Fam Med. 2004 Mar-Apr;2(2):139-44. Related Articles, Links
The mortality risk of elevated serum transferrin saturation
and consumption of dietary iron.
Mainous AG 3rd, Wells B, Carek PJ, Gill JM, Geesey ME.
Department of Family Medicine, Medical University of South
Carolina, Charleston, SC 29425, USA. [email hidden]
BACKGROUND: Recent data shows an increased mortality risk
associated with elevated transferrin saturation. Because
ingestion of dietary iron may contribute to iron overload in
persons with elevated transferrin saturation, we
investigated the relationship between elevated transferrin
saturation, ingestion of dietary iron and red meat, and
mortality. METHODS: This 12-year cohort study used data from
the second National Health and Nutrition Examination Survey
1976-1980 (NHANES II) and the NHANES II Mortality Study
1992. Population estimates were based on 9,229 persons aged
35 to 70 years at baseline. A Cox proportional hazards
analysis was performed based on levels of transferrin
saturation, intake of dietary iron, and intake of red meat.
The analysis was conducted while controlling for
demographics, severity of illness, body mass index, and
smoking status. RESULTS: Unadjusted analyses indicated that
those who had a high transferrin saturation and reported
high dietary iron or red meat consumption had an increased
mortality risk. The adjusted survival analysis indicated
that persons with elevated transferrin saturation who
reported high dietary iron intake had a hazard ratio for
death of 2.90 (95% confidence interval [CI], 1.39-6.04)
compared with those with normal transferrin saturation
levels and reported low dietary iron intake. Persons who had
a high transferrin saturation and reported high red meat
consumption also had an increased hazard ratio for death
(2.26; 95% CI, 1.45-3.52) compared with those who had normal
transferrin saturation and reported low red meat
consumption. CONCLUSIONS: Ingestion of large quantities of
dietary iron and red meat in persons with high transferrin
saturation is associated with an increase in mortality.
Simple dietary restrictions may reduce the mortality risk
associated with high transferrin saturation.
PMID: 15083854 [PubMed - in process]
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