How a retired US astronaut suffered transient global amnesia on
lipitor:
spacedoc.netlipitor thief of memory.htmlOpen ↗
Australian Adverse Drug Reactions Bulletin (Australia's
equivalent to the FDA) Volume 17, Number 3, August 1998,
section 3, page 3 Simvastatn is listed under "DRUGS THAT
MAKE YOU FORGET" Recognizing the 14 reports of Amnesia under
that drug, .8% of the total adverse effects for that drug.
www.health.gov.au/tga/docs/pdf/aadrbltn/aadr9808.pdf
Statin associated memory loss: analysis of 60 case reports
and review of the literature. Wagstaff LR, Mitton MW, Arvik
BM, Doraiswamy PM. Drug Information Service, Duke University
Medical Center, Durham, North Carolina 27710, USA.
Pharmacotherapy. 2003 Jul;23(7):871-80. Abstract: ww-ww-Open ↗
w.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed-
&list_uids=12885101&dopt=Abstract Full Study Text free on
Medscape: medscape.com458867Open ↗
The Role of Lipid-Lowering Drugs in Cognitive Function: A
Meta-Analysis of Observational Studies from Pharmacotherapy
Mahyar Etminan, Pharm.D., Sudeep Gill, M.D., FRCPC, Ali
Samii, M.D., FRCPC Abstract: ncbi.nlm.nih.govenOpen ↗
trez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12820814&d-
opt=Abstract Full Study Text free on Medscape:
medscape.com456866Open ↗
Muldoon MF, Barger SD, Ryan CM, Flory JD, Lehoczky JP,
Matthews KA, Manuck SB. Effects of lovastatin on cognitive
function and psychological well-being. Am J Med. 2000 May;108(7):538-
46. PMID: 10806282 [PubMed - indexed for MEDLINE] ww-ww-Open ↗
w.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed-
&list_uids=10806282&dopt=Abstract
Simvastatin-Associated Memory Loss Amanda Orsi, Pharm.D.,
Olga Sherman, Pharm.D., and Zegga Woldeselassie, Pharm.D.,
Abstract: The statins are widely used to treat
dyslipidemias. They are generally associated with mild
adverse effects, but rarely, more serious reactions may
occur. A 51-year-old man experienced delayed-onset,
progressive memory loss while receiving simvastatin for
hypercholesterolemia. His therapy was switched to
pravastatin, and memory loss resolved gradually over the
next month, with no recurrence of the adverse effect. from
Pharmacotherapy Page 1 of 3:ion=PXke2H8h99pyNVSCajAh5clptzOAHJSZuNBobSwWmi9veWjdJ2A3%7C-
1468812056489609316/184161392/6/7001/7001/7002/7002/7001/-1
full printable version:
medscape.com409738 printOpen ↗
ADR of the Month September 2001 Vol. 6 No. 9 EDITORS
Michelle W. McCarthy, Pharm.D. Anne E. Hendrick, Pharm.D.
University of Virginia Health System Department of Pharmacy
Services Drug Information Center PO Box 800674
Charlottesville, VA 22908-0674 hsc.virginia.edupharmacyOpen ↗
services/Newsletters/ADR%20of%20the%20Month/ADRMonth%209-
01htm.html
The Tablet, published by the British Columbia Pharmacy
Association, September 2001, Volume 10 no 8. Excerpt: Do HMG-
CoA reductase inhibitors impair memory? After taking
simvastatin for a year, a 51-year-old patient developed
short term memory loss, to the extent of being unable to
complete his sentences because he would forget what he was
going to say. The drug was discontinued, replaced by
pravastatin, and within one month his memory returned.14 In
a separate case, a 67-year-old woman developed impaired short-
term memory, altered mood, social impairment, cognitive
impairment and dementia after one year of atorvastatin
therapy. When atorvastatin was discontinued, her memory,
mood and cognition improved completely.15 Memory impairment
in a patient receiving atorvastatin has been reported to the
BC Regional ADR Centre.
pharmacy.ca/publications/thetablet/pdf_version/BCPhA_Tablet-
Sep2001.pdf See page 11 of 16: