C-Reactive Protein

Quoted message said:

Subject: C-Reactive Protein
From: [email hidden] (J and b 50)
Date: 3/6/2004 11:35 AM Mountain Standard Time
Message-id: <[email hidden]>

I had a blood panel done recently, and the Dr.informed me
that my level was too high. His solution was to have me
take 40mg. of Zocor daily. I was already taking 20mg. I had
major abdominal surgery (aortic aneurysm repair) done 2/12
weeks before the blood test. Doesn't surgery increase the
CRP in the blood? Are there any other factors involved in a
high reading?

jim b.

Elevated iron levels. Iron needs to be .. targeted.

<<snip>> Future research needs to focus on preventive
medicine to decrease iron in patients with elevated lipids.
<<snip>> Am J Cardiol. 2004 Mar 1;93(5):559-62. Links

Association of ferritin and lipids with C-reactive protein.

Mainous AG 3rd, Wells BJ, Everett CJ, Gill JM, King DE.

Department of Family Medicine, Medical University of South
Carolina, Charleston, South Carolina, USA.

C-reactive protein (CRP) and lipids (e.g., low-density
lipoprotein [LDL]) are both markers of cardiovascular
disease risk, yet they are not highly correlated. Oxidative
stress of lipids induced by iron may play a role in vascular
inflammation, as indicated by CRP. The purpose of this study
was to examine, in a representative sample of United States
adults, the relation between ferritin, lipids, and CRP. We
analyzed data on adults (aged >/=25 years) in the National
Health and Nutrition Examination Survey III, a national public-
use data set collected between 1988 and 1994. Ferritin,
total cholesterol, LDL, high-density lipoprotein, and ferritin-
lipid combinations were analyzed in relation to CRP in age-,
gender-, and race-adjusted models as well as models with
other potential confounding variables. In adjusted models,
neither elevated ferritin (odds ratio [OR] 1.11, 95%
confidence interval [CI] .94 to 1.32) nor elevated LDL was
significantly associated with elevated CRP (OR 1.03, 95% CI
0.79 to 1.33). Patients with elevated ferritin and elevated
LDL were more likely to have elevated CRP (OR 1.68; 95% CI
1.06 to 2.68). Patients with elevated ferritin and low high-
density lipoprotein were also more likely to have elevated
CRP (OR 1.71; 95% CI 1.28 to 2.27). These results suggest
that both iron and lipids induce inflammation. Future
research needs to focus on preventive medicine to decrease
iron in patients with elevated lipids.

PMID: 14996579 [PubMed - in process]

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J and b 50 said:

I had a blood panel done recently, and the Dr.informed me
that my level was too high. His solution was to have me
take 40mg. of Zocor daily. I was already taking 20mg. I
had major abdominal surgery (aortic aneurysm repair) done
2/12 weeks before the blood test. Doesn't surgery increase
the CRP in the blood? Are there any other factors involved
in a high reading?

jim b.

Yes, the surgery could have elevated the CRP level
measurement a couple of weeks later. There is little solid
evidence that treating to reduce CRP to a specific level is
of benefit. The decision about what dose of a statin to use
in a specific patient, and what target to aim for, is
fairly complex, and it is possible that CRP should play
into that decision.

--
David Rind [email hidden]

(J and b 50) said:

I had a blood panel done recently, and the Dr.informed me
that my level was too high.

hsCRP is a nonspecific inflammatory marker that has been
shown to correlate with increased cardiovascular risk. If an
elevated level is obtained, it should be repeated four weeks
later before basing treatment decisions on the results. Both
results should be averaged. If a level of 10 or greater is
obtained, it's noncardiac inflammation. hsCRP can be lowered
by lifestyle modifications and aspirin as well as statins.
Your doctor may have other reasons to recommend a statin.

Quoted message said:

Subject: Re: C-Reactive Protein
From: anon [email hidden]
Date: 3/6/2004 9:22 PM Mountain Standard Time
Message-id: <2004030623221675249%anon@anoncom>

On 2004-03-06 13:35:02 -0500, [email hidden] (J and b

50) said:

I had a blood panel done recently, and the Dr.informed me
that my level

was

Quoted message said:

too high.

hsCRP is a nonspecific inflammatory marker that has been
shown to correlate with increased cardiovascular risk.

And since iron has been VERY recently been implicated in the
'risk' of cardiovascular problems ..

tinyurl.com2ucgmOpen ↗

Quoted message said:

If an elevated level is obtained, it should be repeated
four weeks later before basing treatment decisions on the
results. Both results should be averaged. If a level of 10
or greater is obtained, it's noncardiac inflammation. hsCRP
can be lowered by lifestyle modifications and aspirin as
well as statins. Your doctor may have other reasons to
recommend a statin.

Aspirin has been hypothesized to 'work' DUE TO its
iron binding qualities .. production of ferritin an
iron binder ..

tinyurl.comyv7rgOpen ↗

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pages.ivillage.commanisaherbivoreOpen ↗ DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

(doe) said:

Aspirin has been hypothesized to 'work' DUE TO its iron
binding qualities .. production of ferritin an iron
binder ..

*Cough* ([censored]!) *Cough*

(doe) said:

Just because the articles are .. old .. 'could' simply ..
mean .. YOU .. are NOT .. as UP on things as you seem to
want everyone to believe ..

Look, I don't care *what* you believe. [censored] is [censored],
even if *you* think it's true.

The *real* mechanism of action of aspirin is not the
"mystery" you seem to imply that it is. I'm not here to
teach basic pharmacology, but then you'd know that if you
read valid scientific literature instead of pseudo-
scientific rubbish.

(doe) said:

Who loves ya.

Not me, putz.

Quoted message said:

I had a blood panel done recently, and the Dr.informed me
that my level was too high.

Periodontal disease has been noted to increase C reative
proteins. Have you had your dental exam recently?

Shirley Gutkowski, RDH, BSDH "Everbody wants to save the
earth - nobody wants to help Mom to do the dishes."
- P. J. O'Rourke
~~~~~~~~~
dentistry.comporalhealth 02.aspOpen ↗

On 2004-03-06 13:35:02 -0500, [email hidden] (J and b 50) said:

Hopefully, he did an hsCRP, not a "regular" CRP. hs (high
sensitivity) CRP is the cardiovascular risk marker. Before
basing treatment decisions on hsCRP, it should be repeated
in 4 weeks, and the two values should be averaged.
Exceedingly high (>11) hsCRP values are almost certainly not
elevated for cardiac reasons. The real impact of treating
elevated hsCRP has not been determined, nor do we know if
reducing hsCRP influences outcomes. All we know at this
point is that hsCRP is one of several risk markers for
cardiovascular disease. The clinical utility of hsCRP
measurement and treatment needs to be taken in context with
your other cardiovascular risk factors. Discuss this with
your doctor.

Quoted message said:

I had a blood panel done recently, and the Dr.informed me
that my level was too high. His solution was to have me
take 40mg. of Zocor daily. I was already taking 20mg. I
had major abdominal surgery (aortic aneurysm repair) done
2/12 weeks before the blood test. Doesn't surgery increase
the CRP in the blood? Are there any other factors involved
in a high reading?

Shirley Gutkowski RDH <[email hidden]> wrote:
: >I had a blood panel done recently, and the Dr.informed me
: >that my level was too high.

: Periodontal disease has been noted to increase C reative
: proteins. Have you had your dental exam recently?

Make that "dental cleaning and scaling"...